The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme a reductase and the cholesterol synthesis pathway

Molecular and Cellular Biology

Volumn 34, Issue 7, 2014, Pages 1262-1270

  Zelcer, Noam ^a   Sharpe, Laura J ^b   Loregger, Anke ^a   Kristiana, Ika ^b   Cook, Emma C L ^a   Phan, Lisa ^b   Stevenson, Julian ^b   Brown, Andrew J ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; COENZYME A; MEMBRANE ASSOCIATED RING FINGER 6 LIGASE; SQUALENE MONOOXYGENASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CHOLESTEROL SYNTHESIS; ENZYME ACTIVITY; ENZYME DEGRADATION; GENE OVEREXPRESSION; GENE SILENCING; LIVER CELL; NONHUMAN; PRIORITY JOURNAL;

CELL LINE; CHOLESTEROL; ENZYME STABILITY; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HEP G2 CELLS; HEPATOCYTES; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; MEMBRANE PROTEINS; MEVALONIC ACID; MODELS, BIOLOGICAL; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SQUALENE MONOOXYGENASE; UBIQUITIN-PROTEIN LIGASES;

EID: 84895820661     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.01140-13     Document Type: Article

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