The effects of long-term daily folic acid and vitamin B12 supplementation on genomewide DNA methylation in elderly subjects

Clinical Epigenetics

Volumn 7, Issue 1, 2015, Pages

  Kok, Dieuwertje E G ^a   Dhonukshe Rutten, Rosalie A M ^a   Lute, Carolien ^a   Heil, Sandra G ^b   Uitterlinden, André G ^b   Van Der Velde, Nathalie ^b,c   Van Meurs, Joyce B J ^b   Van Schoor, Natasja M ^d   Hooiveld, Guido J E J ^a   De Groot, Lisette C P G M ^a   Kampman, Ellen ^a   Steegenga, Wilma T ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

B vitamins; Cancer; Development; DNA methylation; Elderly; Epigenetics; Folic acid; Infinium 450k BeadChip; Intervention trial; One carbon metabolism; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PLACEBO; PROTEIN NODAL;

3' UNTRANSLATED REGION; AGED; AMINO ACID BLOOD LEVEL; ARHI GENE; ARMC8 GENE; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CPG ISLAND; DIRAS3 GENE; DNA METHYLATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; FEMALE; FOLIC ACID BLOOD LEVEL; FRACTURE; GENE; GENETIC ASSOCIATION; GRXCR1 GENE; HOX GENE; HOXA4 GENE; HOXB7 GENE; HUMAN; HYPERHOMOCYSTEINEMIA; INTERVENTION STUDY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MTHFR GENE; NODAL GENE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION; VITAMIN BLOOD LEVEL;

EID: 84946811443     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/s13148-015-0154-5     Document Type: Article

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