Pre- and postfortification intake of folate and risk of colorectal cancer in a large prospective cohort study in the United States

American Journal of Clinical Nutrition

Volumn 94, Issue 4, 2011, Pages 1053-1062

  Gibson, Todd M ^a,b   Weinstein, Stephanie J ^b   Pfeiffer, Ruth M ^b   Hollenbeck, Albert R ^c   Subar, Amy F ^b   Schatzkin, Arthur ^b   Mayne, Susan T ^a   Stolzenberg Solomon, Rachael ^b  

^a YALE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c AARP   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID;

ADULT; AGED; ARTICLE; CANCER RISK; COLORECTAL CANCER; DIETARY INTAKE; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; FOOD FREQUENCY QUESTIONNAIRE; HUMAN; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; UNITED STATES;

AGED; CEREALS; COHORT STUDIES; COLORECTAL NEOPLASMS; DIET; DIETARY SUPPLEMENTS; FOLIC ACID; FOLLOW-UP STUDIES; FOOD, FORTIFIED; HUMANS; INCIDENCE; LEGISLATION, FOOD; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; QUESTIONNAIRES; REGISTRIES; RISK; UNITED STATES;

EID: 80053188657     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.110.002659     Document Type: Article

References (58)

1. Choi SW, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr 2000;130:129-32. (Pubitemid 30073783)
2. Kim YI. Folate and carcinogenesis: evidence, mechanisms, and implications. J Nutr Biochem 1999;10(2):66-88.
3. Zingg JM, Jones PA. Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis 1997;18:869-82. (Pubitemid 28132329)
4. Kim YI. Folate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res 2007;51:267-92.
5. World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition, physical activity and the prevention of cancer: a global perspective. Washington, DC: AICR, 2007.
6. Kim DH, Smith-Warner SA, Spiegelman D, Yaun SS, Colditz GA, Freudenheim JL, Giovannucci E, Goldbohm RA, Graham S, Harnack L, et al. Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer. Cancer Causes Control 2010;21:1919-30.
7. Roswall N, Olsen A, Christensen J, Dragsted LO, Overvad K, Tjonneland A. Micronutrient intake and risk of colon and rectal cancer in a Danish cohort. Cancer Epidemiol 2010;34(1):40-6.
8. Eussen SJ, Vollset SE, Igland J, Meyer K, Fredriksen A, Ueland PM, Jenab M, Slimani N, Boffetta P, Overvad K, et al. Plasma folate, related genetic variants, and colorectal cancer risk in EPIC. Cancer Epidemiol Biomarkers Prev 2010;19(5):1328-40.
9. Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, McKeown-Eyssen G, Summers RW, Rothstein RI, Burke CA, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 2007;297(21):2351-9. (Pubitemid 46883748)
10. Kim YI. Folate: a magic bullet or a double edged sword for colorectal cancer prevention? Gut 2006;55(10):1387-9.
11. Kim YI. Folic acid fortification and supplementation-good for some but not so good for others. Nutr Rev 2007;65:504-11.
12. Ulrich CM. Folate and cancer prevention: a closer look at a complex picture. Am J Clin Nutr 2007;86(2):271-3. (Pubitemid 47256907)
13. Quinlivan EP, Gregory JF III. Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr 2003;77:221-5. (Pubitemid 36015395)
14. Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 1999;340:1449-54. (Pubitemid 29220543)
15. Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ. Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr 2005;82(2):442-50.
16. Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Wong LY. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 2001;285(23):2981-6. (Pubitemid 32550116)
17. Ulrich CM, Potter JD. Folate supplementation: too much of a good thing? Cancer Epidemiol Biomarkers Prev 2006;15(2):189-93. (Pubitemid 43342163)
18. Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G, Rosenberg IH. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev 2007;16(7):1325-9.
19. Schatzkin A, Subar AF, Thompson FE, Harlan LC, Tangrea J, Hollenbeck AR, Hurwitz PE, Coyle L, Schussler N, Michaud DS, et al. Design and serendipity in establishing a large cohort with wide dietary intake distributions: the National Institutes of Health-American Association of Retired Persons Diet and Health Study. Am J Epidemiol 2001;154:1119-25. (Pubitemid 33140635)
20. Michaud DS, Midthune DD, Hermansen S, Leitzmann M, Harlan LC, Kipnis V, Schatzkin A. Comparison of cancer registry case ascertainment with SEER estimates and self-reporting in a subset of the NIH-AARP Diet and health Study. J Registry Manag 2005;32:70-5.
21. Fritz AG. International classification of diseases for oncology: ICD-O. 3rd ed. Geneva, Switzerland: World Health Organization, 2000.
22. Subar AF, Midthune D, Kulldorff M, Brown CC, Thompson FE, Kipnis V, Schatzkin A. Evaluation of alternative approaches to assign nutrient values to food groups in food frequency questionnaires. Am J Epidemiol 2000;152:279-86. (Pubitemid 30640251)
23. Dixon LB, Zimmerman TP, Kahle LL, Subar AF. Adding carotenoids to the NCI Diet History Questionnaire Database. J Food Compost Anal 2003;16:269-80. (Pubitemid 36747900)
24. Thompson FE, Kipnis V, Midthune D, Freedman LS, Carroll RJ, Subar AF, Brown CC, Butcher MS, Mouw T, Leitzmann M, et al. Performance of a food-frequency questionnaire in the US NIH-AARP (National Institutes of Health-American Association of Retired Persons) Diet and Health Study. Public Health Nutr 2008;11(2):183-95.
25. Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986;124:17-27. (Pubitemid 16095831)
26. Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med 1989;8:551-61. (Pubitemid 19116001)
27. Pierce DA, Preston DL. Joint analysis of site-specific cancer risks for the atomic bomb survivors. Radiat Res 1993;134:134-42. (Pubitemid 23157438)
28. Flood A, Caprario L, Chaterjee N, Lacey JV Jr, Schairer C, Schatzkin A. Folate, methionine, alcohol, and colorectal cancer in a prospective study of women in the United States. Cancer Causes Control 2002;13:551-61. (Pubitemid 34833107)
29. Flood A, Velie EM, Chaterjee N, Subar AF, Thompson FE, Lacey JV Jr, Schairer C, Troisi R, Schatzkin A. Fruit and vegetable intakes and the risk of colorectal cancer in the Breast Cancer Detection Demonstration Project follow-up cohort. Am J Clin Nutr 2002;75:936-43. (Pubitemid 34441264)
30. Harnack L, Jacobs DR Jr, Nicodemus K, Lazovich D, Anderson K, Folsom AR. Relationship of folate, vitamin B-6, vitamin B-12, and methionine intake to incidence of colorectal cancers. Nutr Cancer 2002;43:152-8. (Pubitemid 36134089)
31. Konings EJ, Goldbohm RA, Brants HA, Saris WH, van den Brandt PA. Intake of dietary folate vitamers and risk of colorectal carcinoma: results from The Netherlands Cohort Study. Cancer 2002;95:1421-33.
32. Larsson SC, Giovannucci E, Wolk A. A prospective study of dietary folate intake and risk of colorectal cancer: modification by caffeine intake and cigarette smoking. Cancer Epidemiol Biomarkers Prev 2005;14(3):740-3. (Pubitemid 40489226)
33. Terry P, Jain M, Miller AB, Howe GR, Rohan TE. Dietary intake of folic acid and colorectal cancer risk in a cohort of women. Int J Cancer 2002;97:864-7. (Pubitemid 34106346)
34. Wei EK, Giovannucci E, Wu K, Rosner B, Fuchs CS, Willett WC, Colditz GA. Comparison of risk factors for colon and rectal cancer. Int J Cancer 2004;108:433-42. (Pubitemid 37549610)
35. Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Willett WC. Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 1995;87:265-73.
36. Giovannucci E, Stampfer MJ, Colditz GA, Rimm EB, Trichopoulos D, Rosner BA, Speizer FE, Willett WC. Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 1993;85:875-84. (Pubitemid 23157127)
37. Fuchs CS, Willett WC, Colditz GA, Hunter DJ, Stampfer MJ, Speizer FE, Giovannucci EL. The influence of folate and multivitamin use on the familial risk of colon cancer in women. Cancer Epidemiol Biomarkers Prev 2002;11:227-34. (Pubitemid 34326998)
38. Ulrich CM, Potter JD. Folate and cancer-timing is everything. JAMA 2007;297(21):2408-9.
39. Logan RF, Grainge MJ, Shepherd VC, Armitage NC, Muir KR. Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology 2008;134(1):29-38. (Pubitemid 350309319)
40. Wu K, Platz EA, Willett WC, Fuchs CS, Selhub J, Rosner BA, Hunter DJ, Giovannucci E. A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. Am J Clin Nutr 2009;90(6): 1623-31.
41. Kim YI. Folic acid supplementation and cancer risk: point. Cancer Epidemiol Biomarkers Prev 2008;17(9):2220-5.
42. Osterhues A, Holzgreve W, Michels KB. Shall we put the world on folate? Lancet 2009;374(9694):959-61.
43. Sauer J, Mason JB, Choi SW. Too much folate: a risk factor for cancer and cardiovascular disease? Curr Opin Clin Nutr Metab Care 2009;12: 30-6.
44. Solomons NW. Food fortification with folic acid: has the other shoe dropped? Nutr Rev 2007;65:512-5. (Pubitemid 351804343)
45. Ulrich CM. Folate and cancer prevention-where to next? Counterpoint. Cancer Epidemiol Biomarkers Prev 2008;17(9):2226-30.
46. Hirsch S, Sanchez H, Albala C, De la Maza MP, Barrera G, Leiva L, Bunout D. Colon cancer in Chile before and after the start of the flour fortification program with folic acid. Eur J Gastroenterol Hepatol 2009; 21:436-9.
47. Luebeck EG, Moolgavkar SH, Liu AY, Boynton A, Ulrich CM. Does folic acid supplementation prevent or promote colorectal cancer? Results from model-based predictions. Cancer Epidemiol Biomarkers Prev 2008;17(6):1360-7.
48. Leslie A, Carey FA, Pratt NR, Steele RJC. The colorectal adenomacarcinoma sequence. Br J Surg 2002;89:845-60.
49. Cannon-Albright LA, Bishop DT, Samowitz W, DiSario JA, Lee R, Burt RW. Colonic polyps in an unselected population: prevalence, characteristics, and associations. Am J Gastroenterol 1994;89:827-31. (Pubitemid 24165903)
50. Giovannucci E, Stampfer MJ, Colditz GA, Hunter DJ, Fuchs C, Rosner BA, Speizer FE, Willett WC. Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann Intern Med 1998; 129:517-24. (Pubitemid 28460290)
51. Jacobs EJ, Connell CJ, Chao A, McCullough ML, Rodriguez C, Thun MJ, Calle EE. Multivitamin use and colorectal cancer incidence in a US cohort: does timing matter? Am J Epidemiol 2003;158:621-8. (Pubitemid 37175509)
52. Lee JE, Willett WC, Fuchs CS, Smith-Warner SA, Wu K, Ma J, Giovannucci E. Folate intake and risk of colorectal cancer and adenoma: modification by time. Am J Clin Nutr 2011;93:817-25.
53. Neuhouser ML, Wassertheil-Smoller S, Thomson C, Aragaki A, Anderson GL, Manson JE, Patterson RE, Rohan TE, van Horn L, Shikany JM, et al. Multivitamin use and risk of cancer and cardiovascular disease in the Women's Health Initiative cohorts. Arch Intern Med 2009;169(3):294-304.
54. Sanjoaquin MA, Allen N, Couto E, Roddam AW, Key TJ. Folate intake and colorectal cancer risk: a meta-analytical approach. Int J Cancer 2005;113:825-8. (Pubitemid 40101266)
55. Bailey RL, Mills JL, Yetley EA, Gahche JJ, Pfeiffer CM, Dwyer JT, Dodd KW, Sempos CT, Betz JM, Picciano MF. Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged. or =60 y in the United States. Am J Clin Nutr 2010;92(2):383-9.
56. Troen AM, Mitchell B, Sorensen B, Wener MH, Johnston A, Wood B, Selhub J, McTiernan A, Yasui Y, Oral E, et al. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 2006;136(1):189-94. (Pubitemid 43156507)
57. Protiva P, Mason JB, Liu Z, Hopkins ME, Nelson C, Marshall JR, Lambrecht RW, Pendyala S, Kopelovich L, Kim M, et al. Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis. Cancer Prev Res 2011;4:530-43.
58. Kipnis V, Subar AF, Midthune D, Freedman LS, Ballard-Barbash R, Troiano RP, Bingham S, Schoeller DA, Schatzkin A, Carroll RJ. Structure of dietary measurement error: results of the OPEN biomarker study. Am J Epidemiol 2003;158:14-26.