Embryonic morphogen nodal is associated with progression and poor prognosis of hepatocellular carcinoma

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Chen, Jing ^a   Liu, Wen Bin ^a   Jia, Wei Dong ^a   Xu, Ge Liang ^a   Ma, Jin Liang ^a   Ren, Yun ^a   Chen, Hao ^a   Sun, Si Nan ^a   Huang, Mei ^a   Li, Jian Sheng ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CD34 ANTIGEN; INDOCYANINE GREEN; PROTEIN NODAL; SHORT HAIRPIN RNA; VIMENTIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER PROGNOSIS; CANCER SURVIVAL; CANCER TISSUE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER TUMOR; LYMPH VESSEL METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROVESSAL DENSITY; NODAL GENE; ONCOLOGICAL PARAMETERS; PARACARCINOMATOUS TISSUE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR VOLUME; UPREGULATION; WESTERN BLOTTING;

AGED; ANTIGENS, CD34; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; DISEASE PROGRESSION; EMBRYO, MAMMALIAN; FEMALE; FROZEN SECTIONS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; NODAL PROTEIN; PROGNOSIS; RNA, MESSENGER; RNA, SMALL INTERFERING; VIMENTIN;

EID: 84908153528     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0085840     Document Type: Article

References (35)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
2. Forner A, Llovet JM, Bruix J (2012) Hepatocellular carcinoma. Lancet 379: 1245-1255.
3. Conlon FL, Lyons KM, Takaesu N, Barth KS, Kispert A, et al. (1994) A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development 120: 1919-1928.
4. Shen MM (2007) Nodal signaling: developmental roles and regulation. Development 134: 1023-1034.
5. Schier AF (2009) Nodal morphogens. Cold Spring Harb Perspect Biol 1: a003459.
6. Hendrix MJ, Seftor EA, Seftor RE, Kasemeier-Kulesa J, Kulesa PM, et al. (2007) Reprogramming metastatic tumour cells with embryonic microenvironments. Nat Rev Cancer 7: 246-255.
7. Schier AF, Shen MM (2000) Nodal signalling in vertebrate development. Nature 403: 385-389.
8. Quail DF, Zhang G, Findlay SD, Hess DA, Postovit LM (2013) Nodal promotes invasive phenotypes via a mitogen-activated protein kinase-dependent pathway. Oncogene.
9. Lee CC, Jan HJ, Lai JH, Ma HI, Hueng DY, et al. (2010) Nodal promotes growth and invasion in human gliomas. Oncogene 29: 3110-3123.
10. Strizzi L, Postovit LM, Margaryan NV, Seftor EA, Abbott DE, et al. (2008) Emerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progression. Breast Dis 29: 91-103.
11. Topczewska JM, Postovit LM, Margaryan NV, Sam A, Hess AR, et al. (2006) Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med 12: 925-932.
12. Lawrence MG, Margaryan NV, Loessner D, Collins A, Kerr KM, et al. (2011) Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells. Prostate 71: 1198-1209.
13. Lonardo E, Hermann PC, Mueller MT, Huber S, Balic A, et al. (2011) Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy. Cell Stem Cell 9: 433-446.
14. Papageorgiou I, Nicholls PK, Wang F, Lackmann M, Makanji Y, et al. (2009) Expression of nodal signalling components in cycling human endometrium and in endometrial cancer. Reprod Biol Endocrinol 7: 122.
15. Xu G, Zhong Y, Munir S, Yang BB, Tsang BK, et al. (2004) Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. J Clin Endocrinol Metab 89: 5523-5534.
16. Sun C, Sun L, Jiang K, Gao DM, Kang XN, et al. (2013) NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway. Int J Biochem Cell Biol 45: 1099-1108.
17. Li Y, Tang Y, Ye L, Liu B, Liu K, et al. (2003) Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray. J Cancer Res Clin Oncol 129: 43-51.
18. Li Y, Tian B, Yang J, Zhao L, Wu X, et al. (2004) Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics. J Cancer Res Clin Oncol 130: 460-468.
19. Edmondson HA, Steiner PE (1954) Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 7: 462-503.
20. Yu L, Harms PW, Pouryazdanparast P, Kim DS, Ma L, et al. (2010) Expression of the embryonic morphogen Nodal in cutaneous melanocytic lesions. Mod Pathol 23: 1209-1214.
21. Chen MH, Yip GW, Tse GM, Moriya T, Lui PC, et al. (2008) Expression of basal keratins and vimentin in breast cancers of young women correlates with adverse pathologic parameters. Mod Pathol 21: 1183-1191.
22. Weidner N, Semple JP, Welch WR, Folkman J (1991) Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 324: 1-8.
23. Quail DF, Walsh LA, Zhang G, Findlay SD, Moreno J, et al. (2012) Embryonic protein nodal promotes breast cancer vascularization. Cancer Res 72: 3851-3863.
24. Quail DF, Zhang G, Walsh LA, Siegers GM, Dieters-Castator DZ, et al. (2012) Embryonic morphogen nodal promotes breast cancer growth and progression. PLoS One 7: e48237.
25. Postovit LM, Margaryan NV, Seftor EA, Hendrix MJ (2008) Role of nodal signaling and the microenvironment underlying melanoma plasticity. Pigment Cell Melanoma Res 21: 348-357.
26. Zhong Y, Xu G, Ye G, Lee D, Modica-Amore J, et al. (2009) Nodal and activin receptor-like kinase 7 induce apoptosis in human breast cancer cell lines: Role of caspase 3. Int J Physiol Pathophysiol Pharmacol 1: 83-96.
27. Munir S, Xu G, Wu Y, Yang B, Lala PK, et al. (2004) Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. J Biol Chem 279: 31277-31286.
28. Savagner P (2001) Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. Bioessays 23: 912-923.
29. Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
30. Kimura H, Nakajima T, Kagawa K, Deguchi T, Kakusui M, et al. (1998) Angiogenesis in hepatocellular carcinoma as evaluated by CD34 immunohistochemistry. Liver 18: 14-19.
31. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, et al. (2003) Cell migration: integrating signals from front to back. Science 302: 1704-1709.
32. Demuth T, Berens ME (2004) Molecular mechanisms of glioma cell migration and invasion. J Neurooncol 70: 217-228.
33. Strizzi L, Hardy KM, Kirschmann DA, Ahrlund-Richter L, Hendrix MJ (2012) Nodal expression and detection in cancer: experience and challenges. Cancer Res 72: 1915-1920.
34. Quail DF, Siegers GM, Jewer M, Postovit LM (2013) Nodal signalling in embryogenesis and tumourigenesis. Int J Biochem Cell Biol 45: 885-898.
35. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144: 646-674.