TSPO in a murine model of Sandhoff disease: Presymptomatic marker of neurodegeneration and disease pathophysiology

Neurobiology of Disease

Volumn 85, Issue , 2016, Pages 174-186

  Loth, Meredith K ^a   Choi, Judy ^a   McGlothan, Jennifer L ^a   Pletnikov, Mikhail V ^b   Pomper, Martin G ^b   Guilarte, Tomás R ^a,b  

^a Columbia University ^*  (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Astrocytes; Biomarker; Microglia; Neurodegeneration; Sandhoff disease; Translocator protein 18kDa; TSPO

Indexed keywords

CARRIER PROTEIN; GANGLIOSIDE GM2; GLIAL FIBRILLARY ACIDIC PROTEIN; 4 AMINOBUTYRIC ACID RECEPTOR; BIOLOGICAL MARKER; BZRP PROTEIN, MOUSE;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BIOTINYLATION; BRAIN CORTEX; CONTROLLED STUDY; DISEASE COURSE; HEART PERFUSION; HETEROZYGOSITY; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MICROGLIA; MORPHOLOGY; MOTOR PERFORMANCE; MOUSE; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; SANDHOFF DISEASE; SIGNAL NOISE RATIO; SOMATOSENSORY CORTEX; AGING; ANIMAL; BRAIN; DIAGNOSTIC IMAGING; DISEASE MODEL; GM2 GANGLIOSIDOSIS; KNOCKOUT MOUSE; LONGITUDINAL STUDY; METABOLISM; MOTOR ACTIVITY; PATHOLOGY; PHYSIOLOGY; PRODROMAL SYMPTOM; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY;

AGING; ANIMALS; ASTROCYTES; BIOMARKERS; BRAIN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GANGLIOSIDOSES, GM2; LONGITUDINAL STUDIES; MICE, KNOCKOUT; MICROGLIA; MOTOR ACTIVITY; NERVE DEGENERATION; PRODROMAL SYMPTOMS; RECEPTORS, GABA; SANDHOFF DISEASE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84946761600     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2015.11.001     Document Type: Article

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