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Volumn 127, Issue 1, 2012, Pages 277-295

Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb2+: Implications for an environmental basis of neurodevelopmental disorders

Author keywords

BDNF; Epigenetics; Hippocampus; Huntingtin; MeCP2; Neuron; Phosphorylation; Synapsin I; Synaptogenesis; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; HUNTINGTIN; LEAD; METHYL CPG BINDING PROTEIN 2; NEUROTROPHIN RECEPTOR P75; SYNAPSIN I; TROPOMYOSIN;

EID: 84860151670     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs090     Document Type: Article
Times cited : (91)

References (91)
  • 1
    • 39749193120 scopus 로고    scopus 로고
    • MeCP2 deficiency in the brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB production
    • Abuhatzira, L., Makedonski, K., Kaufman, Y., Razin, A., and Shemer, R. (2007). MeCP2 deficiency in the brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB production. Epigenetics 2, 214-222.
    • (2007) Epigenetics , vol.2 , pp. 214-222
    • Abuhatzira, L.1    Makedonski, K.2    Kaufman, Y.3    Razin, A.4    Shemer, R.5
  • 2
    • 0020066986 scopus 로고
    • Neonatal lead exposure alters the dendritic development of hippocampal dentate granule cells
    • Alfano, D. P., and Petit, T. L. (1982). Neonatal lead exposure alters the dendritic development of hippocampal dentate granule cells. Exp. Neurol. 75, 275-288.
    • (1982) Exp. Neurol. , vol.75 , pp. 275-288
    • Alfano, D.P.1    Petit, T.L.2
  • 3
    • 0025125719 scopus 로고
    • Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead
    • Alkondon, M., Costa, A. C., Radhakrishnan, V., Aronstam, R. S., and Albuquerque, E. X. (1990). Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead. FEBS Lett. 261, 124-130.
    • (1990) FEBS Lett , vol.261 , pp. 124-130
    • Alkondon, M.1    Costa, A.C.2    Radhakrishnan, V.3    Aronstam, R.S.4    Albuquerque, E.X.5
  • 5
    • 0033694754 scopus 로고    scopus 로고
    • The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase
    • Atwal, J. K., Massie, B., Miller, F. D., and Kaplan, D. R. (2000). The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase. Neuron 27, 265-277.
    • (2000) Neuron , vol.27 , pp. 265-277
    • Atwal, J.K.1    Massie, B.2    Miller, F.D.3    Kaplan, D.R.4
  • 6
    • 0032559622 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
    • Bamji, S. X., Majdan, M., Pozniak, C. D., Belliveau, D. J., Aloyz, R., Kohn, J., Causing, C. G., and Miller, F. D. (1998). The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J. Cell Biol. 140, 911-923.
    • (1998) J. Cell Biol. , vol.140 , pp. 911-923
    • Bamji, S.X.1    Majdan, M.2    Pozniak, C.D.3    Belliveau, D.J.4    Aloyz, R.5    Kohn, J.6    Causing, C.G.7    Miller, F.D.8
  • 7
    • 0017350927 scopus 로고
    • Rat hippocampal neurons in dispersed cell culture
    • Banker, G. A., and Cowan, W. M. (1977). Rat hippocampal neurons in dispersed cell culture. Brain Res. 126, 397-425.
    • (1977) Brain Res , vol.126 , pp. 397-425
    • Banker, G.A.1    Cowan, W.M.2
  • 8
    • 0026468274 scopus 로고
    • Low-level lead exposure, intelligence and academic achievement: A long-term follow-up study
    • Bellinger, D. C., Stiles, K. M., and Needleman, H. L. (1992). Low-level lead exposure, intelligence and academic achievement: A long-term follow-up study. Pediatrics 90, 855-861.
    • (1992) Pediatrics , vol.90 , pp. 855-861
    • Bellinger, D.C.1    Stiles, K.M.2    Needleman, H.L.3
  • 9
    • 0033081042 scopus 로고    scopus 로고
    • Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR
    • Bibel, M., Hoppe, E., and Barde, Y. A. (1999). Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. EMBO J. 18, 616-622.
    • (1999) EMBO J , vol.18 , pp. 616-622
    • Bibel, M.1    Hoppe, E.2    Barde, Y.A.3
  • 10
    • 84455193330 scopus 로고    scopus 로고
    • Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: Implications for Alzheimer's disease
    • Bihaqi, S. W., Huang, H., Wu, J., and Zawia, N. H. (2011). Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: Implications for Alzheimer's disease. J. Alzheimer's Dis. 27, 819-833.
    • (2011) J. Alzheimer's Dis. , vol.27 , pp. 819-833
    • Bihaqi, S.W.1    Huang, H.2    Wu, J.3    Zawia, N.H.4
  • 11
    • 14744272637 scopus 로고    scopus 로고
    • Neurotrophin-mediated rapid signaling in the central nervous system: Mechanisms and functions
    • Blum, R., and Konnerth, A. (2005). Neurotrophin-mediated rapid signaling in the central nervous system: Mechanisms and functions. Physiol. (Bethesda) 20, 70-78.
    • (2005) Physiol. (Bethesda) , vol.20 , pp. 70-78
    • Blum, R.1    Konnerth, A.2
  • 12
    • 34248233012 scopus 로고    scopus 로고
    • Increased vulnerability of hippocampal neurons with age in culture: Temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels
    • Brewer, L. D., Thibault, O., Staton, J., Thibault, V., Rogers, J. T., Garcia-Ramos, G., Kraner, S., Landfield, P. W., and Porter, N. M. (2007). Increased vulnerability of hippocampal neurons with age in culture: Temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels. Brain Res. 1151, 20-31.
    • (2007) Brain Res , vol.1151 , pp. 20-31
    • Brewer, L.D.1    Thibault, O.2    Staton, J.3    Thibault, V.4    Rogers, J.T.5    Garcia-Ramos, G.6    Kraner, S.7    Landfield, P.W.8    Porter, N.M.9
  • 14
    • 0029965084 scopus 로고    scopus 로고
    • Transphosphorylation of the neurotrophin Trk receptors
    • Canossa, M., Rovelli, G., and Shooter, E. M. (1996). Transphosphorylation of the neurotrophin Trk receptors. J. Biol. Chem. 271, 5812-5818.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5812-5818
    • Canossa, M.1    Rovelli, G.2    Shooter, E.M.3
  • 15
    • 0031039882 scopus 로고    scopus 로고
    • Neurotrophins live or let die: Does p75NTR decide?
    • Carter, B. D., and Lewin, G. R. (1997). Neurotrophins live or let die: Does p75NTR decide? Neuron 18, 187-190.
    • (1997) Neuron , vol.18 , pp. 187-190
    • Carter, B.D.1    Lewin, G.R.2
  • 16
    • 31444434393 scopus 로고    scopus 로고
    • The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression
    • Chang, Q., Khare, G., Dani, V., Nelson, S., and Jaenisch, R. (2006). The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 49, 341-348.
    • (2006) Neuron , vol.49 , pp. 341-348
    • Chang, Q.1    Khare, G.2    Dani, V.3    Nelson, S.4    Jaenisch, R.5
  • 18
    • 37349094048 scopus 로고    scopus 로고
    • BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae
    • Chiaruttini, C., Sonego, M., Baj, G., Simonato, M., and Tongiorgi, E. (2008). BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae. Mol. Cell. Neurosci. 37, 11-19.
    • (2008) Mol. Cell. Neurosci. , vol.37 , pp. 11-19
    • Chiaruttini, C.1    Sonego, M.2    Baj, G.3    Simonato, M.4    Tongiorgi, E.5
  • 20
    • 49149112606 scopus 로고    scopus 로고
    • Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons
    • Colin, E., Zala, D., Liot, G., Rangone, H., Borrell-Pages, M., Li, X. J., Saudou, F., and Humbert, S. (2008). Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. EMBO J. 27, 2124-2134.
    • (2008) EMBO J , vol.27 , pp. 2124-2134
    • Colin, E.1    Zala, D.2    Liot, G.3    Rangone, H.4    Borrell-Pages, M.5    Li, X.J.6    Saudou, F.7    Humbert, S.8
  • 21
    • 0026587147 scopus 로고
    • Pre-natal blood lead levels and learning difficulties in children: An analysis of non-randomly missing categorical data
    • Conaway, M. R., Waternaux, C., Allred, E., Bellinger, D., and Leviton, A. (1992). Pre-natal blood lead levels and learning difficulties in children: An analysis of non-randomly missing categorical data. Stat. Med. 11, 799-811.
    • (1992) Stat. Med. , vol.11 , pp. 799-811
    • Conaway, M.R.1    Waternaux, C.2    Allred, E.3    Bellinger, D.4    Leviton, A.5
  • 22
    • 13144259635 scopus 로고    scopus 로고
    • TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons
    • Davey, F., and Davies, A. M. (1998). TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons. Curr. Biol. 8, 915-918.
    • (1998) Curr. Biol. , vol.8 , pp. 915-918
    • Davey, F.1    Davies, A.M.2
  • 24
    • 0031894950 scopus 로고    scopus 로고
    • Retrograde signaling in the development and modification of synapses
    • Fitzsimonds, R. M., and Poo, M. M. (1998). Retrograde signaling in the development and modification of synapses. Physiol. Rev. 78, 143-170.
    • (1998) Physiol. Rev. , vol.78 , pp. 143-170
    • Fitzsimonds, R.M.1    Poo, M.M.2
  • 26
    • 0027402975 scopus 로고
    • Synaptic vesicle phosphoproteins and regulation of synaptic function
    • Greengard, P., Valtorta, F., Czernik, A. J., and Benfenati, F. (1993). Synaptic vesicle phosphoproteins and regulation of synaptic function. Science 259, 780-785.
    • (1993) Science , vol.259 , pp. 780-785
    • Greengard, P.1    Valtorta, F.2    Czernik, A.J.3    Benfenati, F.4
  • 27
    • 52049127039 scopus 로고    scopus 로고
    • From synapse to nucleus: Calciumdependent gene transcription in the control of synapse development and function
    • Greer, P. L., and Greenberg, M. E. (2008). From synapse to nucleus: Calciumdependent gene transcription in the control of synapse development and function. Neuron 59, 846-860.
    • (2008) Neuron , vol.59 , pp. 846-860
    • Greer, P.L.1    Greenberg, M.E.2
  • 28
    • 33846803880 scopus 로고    scopus 로고
    • Mutation at the TrkB PLC{gamma}-docking site affects hippocampal LTP and associative learning in conscious mice
    • Gruart, A., Sciarretta, C., Valenzuela-Harrington, M., Delgado-Garcia, J. M., and Minichiello, L. (2007). Mutation at the TrkB PLC{gamma}-docking site affects hippocampal LTP and associative learning in conscious mice. Learn. Mem. 14, 54-62.
    • (2007) Learn. Mem. , vol.14 , pp. 54-62
    • Gruart, A.1    Sciarretta, C.2    Valenzuela-Harrington, M.3    Delgado-Garcia, J.M.4    Minichiello, L.5
  • 29
    • 0032550160 scopus 로고    scopus 로고
    • Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure
    • Guilarte, T. R., and McGlothan, J. L. (1998). Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure. Brain Res. 790, 98-107.
    • (1998) Brain Res , vol.790 , pp. 98-107
    • Guilarte, T.R.1    McGlothan, J.L.2
  • 30
    • 0026619470 scopus 로고
    • Age-dependent effects of lead on [3H]MK-801 binding to the NMDA receptor-gated ionophore: In vitro and in vivo studies
    • Guilarte, T. R., and Miceli, R. C. (1992). Age-dependent effects of lead on [3H]MK-801 binding to the NMDA receptor-gated ionophore: In vitro and in vivo studies. Neurosci. Lett. 148, 27-30.
    • (1992) Neurosci. Lett. , vol.148 , pp. 27-30
    • Guilarte, T.R.1    Miceli, R.C.2
  • 31
    • 0037231769 scopus 로고    scopus 로고
    • Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure
    • Guilarte, T. R., Toscano, C. D., McGlothan, J. L., and Weaver, S. A. (2003). Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure. Ann. Neurol. 53, 50-56.
    • (2003) Ann. Neurol. , vol.53 , pp. 50-56
    • Guilarte, T.R.1    Toscano, C.D.2    McGlothan, J.L.3    Weaver, S.A.4
  • 32
    • 0035094767 scopus 로고    scopus 로고
    • A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
    • Guy, J., Hendrich, B., Holmes, M., Martin, J. E., and Bird, A. (2001). A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat. Genet. 27, 322-326.
    • (2001) Nat. Genet. , vol.27 , pp. 322-326
    • Guy, J.1    Hendrich, B.2    Holmes, M.3    Martin, J.E.4    Bird, A.5
  • 33
    • 0027939697 scopus 로고
    • The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins
    • Hantzopoulos, P. A., Suri, C., Glass, D. J., Goldfarb, M. P., and Yancopoulos, G. D. (1994). The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins. Neuron 13, 187-201.
    • (1994) Neuron , vol.13 , pp. 187-201
    • Hantzopoulos, P.A.1    Suri, C.2    Glass, D.J.3    Goldfarb, M.P.4    Yancopoulos, G.D.5
  • 34
    • 0035503313 scopus 로고    scopus 로고
    • Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses
    • Hartmann, M., Heumann, R., and Lessmann, V. (2001). Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses. EMBO J. 20, 5887-5897.
    • (2001) EMBO J , vol.20 , pp. 5887-5897
    • Hartmann, M.1    Heumann, R.2    Lessmann, V.3
  • 36
    • 0041488911 scopus 로고    scopus 로고
    • Trk receptors: Roles in neuronal signal transduction
    • Huang, E. J., and Reichardt, L. F. (2003). Trk receptors: Roles in neuronal signal transduction. Annu. Rev. Biochem. 72, 609-642.
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 609-642
    • Huang, E.J.1    Reichardt, L.F.2
  • 37
    • 23244458906 scopus 로고    scopus 로고
    • The excitoprotective effect of N-methyl-D-aspartate receptors is mediated by a brain-derived neurotrophic factor autocrine loop in cultured hippocampal neurons
    • Jiang, X., Tian, F., Mearow, K., Okagaki, P., Lipsky, R. H., and Marini, A. M. (2005). The excitoprotective effect of N-methyl-D-aspartate receptors is mediated by a brain-derived neurotrophic factor autocrine loop in cultured hippocampal neurons. J. Neurochem. 94, 713-722.
    • (2005) J. Neurochem. , vol.94 , pp. 713-722
    • Jiang, X.1    Tian, F.2    Mearow, K.3    Okagaki, P.4    Lipsky, R.H.5    Marini, A.M.6
  • 41
    • 0019950004 scopus 로고
    • Dendritic spine changes in rat hippocampal pyramidal cells after postnatal lead treatment: A Golgi study
    • Kiraly, E., and Jones, D. G. (1982). Dendritic spine changes in rat hippocampal pyramidal cells after postnatal lead treatment: A Golgi study. Exp. Neurol. 77, 236-239.
    • (1982) Exp. Neurol. , vol.77 , pp. 236-239
    • Kiraly, E.1    Jones, D.G.2
  • 43
    • 18244382548 scopus 로고    scopus 로고
    • Childhood lead poisoning prevention: Too little, too late
    • Lanphear, B. P. (2005). Childhood lead poisoning prevention: Too little, too late. J. Am. Med. Assoc. 293, 2274-2276.
    • (2005) J. Am. Med. Assoc. , vol.293 , pp. 2274-2276
    • Lanphear, B.P.1
  • 45
    • 0035976524 scopus 로고    scopus 로고
    • Regulation of cell survival by secreted proneurotrophins
    • Lee, R., Kermani, P., Teng, K. K., and Hempstead, B. L. (2001). Regulation of cell survival by secreted proneurotrophins. Science 294, 1945-1948.
    • (2001) Science , vol.294 , pp. 1945-1948
    • Lee, R.1    Kermani, P.2    Teng, K.K.3    Hempstead, B.L.4
  • 46
    • 0012315645 scopus 로고    scopus 로고
    • Neurotrophin secretion: Current facts and future prospects
    • Lessmann, V., Gottmann, K., and Malcangio, M. (2003). Neurotrophin secretion: Current facts and future prospects. Prog. Neurobiol. 69, 341-374.
    • (2003) Prog. Neurobiol. , vol.69 , pp. 341-374
    • Lessmann, V.1    Gottmann, K.2    Malcangio, M.3
  • 47
    • 0026747761 scopus 로고
    • Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA
    • Lewis, J. D., Meehan, R. R., Henzel, W. J., Maurer-Fogy, I., Jeppesen, P., Klein, F., and Bird, A. (1992). Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 69, 905-914.
    • (1992) Cell , vol.69 , pp. 905-914
    • Lewis, J.D.1    Meehan, R.R.2    Henzel, W.J.3    Maurer-Fogy, I.4    Jeppesen, P.5    Klein, F.6    Bird, A.7
  • 48
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak, K. J., and Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 49
    • 0242300612 scopus 로고    scopus 로고
    • DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation
    • Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., and Sun, Y. E. (2003). DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302, 890-893.
    • (2003) Science , vol.302 , pp. 890-893
    • Martinowich, K.1    Hattori, D.2    Wu, H.3    Fouse, S.4    He, F.5    Hu, Y.6    Fan, G.7    Sun, Y.E.8
  • 50
    • 0027359034 scopus 로고
    • Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation
    • Metsis, M., Timmusk, T., Arenas, E., and Persson, H. (1993). Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation. Proc. Natl. Acad. Sci. U.S.A. 90, 8802-8806.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 8802-8806
    • Metsis, M.1    Timmusk, T.2    Arenas, E.3    Persson, H.4
  • 51
    • 78049342155 scopus 로고    scopus 로고
    • Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A
    • Metzler, M., Gan, L., Mazarei, G., Graham, R. K., Liu, L., Bissada, N., Lu, G., Leavitt, B. R., and Hayden, M. R. (2010). Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A. J. Neurosci. 30, 14318-14329.
    • (2010) J. Neurosci. , vol.30 , pp. 14318-14329
    • Metzler, M.1    Gan, L.2    Mazarei, G.3    Graham, R.K.4    Liu, L.5    Bissada, N.6    Lu, G.7    Leavitt, B.R.8    Hayden, M.R.9
  • 52
    • 80755153110 scopus 로고    scopus 로고
    • The continuing impact of lead dust on children's blood lead: Comparison of public and private properties in New Orleans
    • Mielke, H. W., Gonzales, C. R., and Mielke, P. W., Jr (2011). The continuing impact of lead dust on children's blood lead: Comparison of public and private properties in New Orleans. Environ. Res. 111, 1164-1172.
    • (2011) Environ. Res. , vol.111 , pp. 1164-1172
    • Mielke, H.W.1    Gonzales, C.R.2    Mielke Jr., P.W.3
  • 54
    • 34848818800 scopus 로고    scopus 로고
    • The relationship between early childhood blood lead levels and performance on end-of-grade tests
    • Miranda, M. L., Kim, D., Galeano, M. A., Paul, C. J., Hull, A. P., and Morgan, S. P. (2007). The relationship between early childhood blood lead levels and performance on end-of-grade tests. Environ. Health Perspect. 115, 1242-1247.
    • (2007) Environ. Health Perspect. , vol.115 , pp. 1242-1247
    • Miranda, M.L.1    Kim, D.2    Galeano, M.A.3    Paul, C.J.4    Hull, A.P.5    Morgan, S.P.6
  • 55
    • 80051934701 scopus 로고    scopus 로고
    • BDNF-TrkB signalling in fear learning: From genetics to neural networks
    • Musumeci, G., and Minichiello, L. (2011). BDNF-TrkB signalling in fear learning: From genetics to neural networks. Rev. Neurosci. 22, 303-315.
    • (2011) Rev. Neurosci. , vol.22 , pp. 303-315
    • Musumeci, G.1    Minichiello, L.2
  • 56
    • 78650993109 scopus 로고    scopus 로고
    • Molecular neurobiology of lead (Pb(2+)): Effects on synaptic function
    • Neal, A. P., and Guilarte, T. R. (2010). Molecular neurobiology of lead (Pb(2+)): Effects on synaptic function. Mol. Neurobiol. 42, 151-160.
    • (2010) Mol. Neurobiol. , vol.42 , pp. 151-160
    • Neal, A.P.1    Guilarte, T.R.2
  • 57
    • 77954360596 scopus 로고    scopus 로고
    • Lead exposure during synaptogenesis alters vesicular proteins and impairs vesicular release: Potential role of NMDA receptordependent BDNF signaling
    • Neal, A. P., Stansfield, K. H., Worley, P. F., Thompson, R. E., and Guilarte, T. R. (2010). Lead exposure during synaptogenesis alters vesicular proteins and impairs vesicular release: Potential role of NMDA receptordependent BDNF signaling. Toxicol. Sci. 116, 249-263.
    • (2010) Toxicol. Sci. , vol.116 , pp. 249-263
    • Neal, A.P.1    Stansfield, K.H.2    Worley, P.F.3    Thompson, R.E.4    Guilarte, T.R.5
  • 59
    • 0034638256 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptor subunit changes are associated with lead-induced deficits of long-term potentiation and spatial learning
    • Nihei, M. K., Desmond, N. L., McGlothan, J. L., Kuhlmann, A. C., and Guilarte, T. R. (2000). N-methyl-D-aspartate receptor subunit changes are associated with lead-induced deficits of long-term potentiation and spatial learning. Neuroscience 99, 233-242.
    • (2000) Neuroscience , vol.99 , pp. 233-242
    • Nihei, M.K.1    Desmond, N.L.2    McGlothan, J.L.3    Kuhlmann, A.C.4    Guilarte, T.R.5
  • 60
    • 0033586398 scopus 로고    scopus 로고
    • NMDAR-2A subunit protein expression is reduced in the hippocampus of rats exposed to Pb2+ during development
    • Nihei, M. K., and Guilarte, T. R. (1999). NMDAR-2A subunit protein expression is reduced in the hippocampus of rats exposed to Pb2+ during development. Brain Res. Mol. Brain Res. 66, 42-49.
    • (1999) Brain Res. Mol Brain Res. , vol.66 , pp. 42-49
    • Nihei, M.K.1    Guilarte, T.R.2
  • 61
    • 80054684724 scopus 로고    scopus 로고
    • Lead poisoning among Arab American and African American children in the Detroit metropolitan area Michigan
    • Nriagu, J., Senthamarai-Kannan, R., Jamil, H., Fakhori, M., and Korponic, S. (2011). Lead poisoning among Arab American and African American children in the Detroit metropolitan area, Michigan. Bull. Environ. Contam. Toxicol. 87, 238-244.
    • (2011) Bull. Environ. Contam. Toxicol. , vol.87 , pp. 238-244
    • Nriagu, J.1    Senthamarai-Kannan, R.2    Jamil, H.3    Fakhori, M.4    Korponic, S.5
  • 62
    • 0035477918 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor triggers a rapid glutamate release through increase of intracellular Ca(2+) and Na(+) in cultured cerebellar neurons
    • Numakawa, T., Matsumoto, T., Adachi, N., Yokomaku, D., Kojima, M., Takei, N., and Hatanaka, H. (2001). Brain-derived neurotrophic factor triggers a rapid glutamate release through increase of intracellular Ca(2+) and Na(+) in cultured cerebellar neurons. J. Neurosci. Res. 66, 96-108.
    • (2001) J. Neurosci. Res. , vol.66 , pp. 96-108
    • Numakawa, T.1    Matsumoto, T.2    Adachi, N.3    Yokomaku, D.4    Kojima, M.5    Takei, N.6    Hatanaka, H.7
  • 63
    • 0037155187 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factorinduced potentiation of Ca(2+) oscillations in developing cortical neurons
    • Numakawa, T., Yamagishi, S., Adachi, N., Matsumoto, T., Yokomaku, D., Yamada, M., and Hatanaka, H. (2002). Brain-derived neurotrophic factorinduced potentiation of Ca(2+) oscillations in developing cortical neurons. J. Biol. Chem. 277, 6520-6529.
    • (2002) J. Biol. Chem. , vol.277 , pp. 6520-6529
    • Numakawa, T.1    Yamagishi, S.2    Adachi, N.3    Matsumoto, T.4    Yokomaku, D.5    Yamada, M.6    Hatanaka, H.7
  • 64
    • 0030426276 scopus 로고    scopus 로고
    • The sensitivity of N-methyl-D-aspartate receptors to lead inhibition is dependent on the receptor subunit composition
    • Omelchenko, I. A., Nelson, C. S., Marino, J. L., and Allen, C. N. (1996). The sensitivity of N-methyl-D-aspartate receptors to lead inhibition is dependent on the receptor subunit composition. J. Pharmacol. Exp. Ther. 278, 15-20.
    • (1996) J. Pharmacol. Exp. Ther. , vol.278 , pp. 15-20
    • Omelchenko, I.A.1    Nelson, C.S.2    Marino, J.L.3    Allen, C.N.4
  • 68
    • 0032055648 scopus 로고    scopus 로고
    • Identification of a signaling pathway involved in calcium regulation of BDNF expression
    • Shieh, P. B., Hu, S. C., Bobb, K., Timmusk, T., and Ghosh, A. (1998). Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron 20, 727-740.
    • (1998) Neuron , vol.20 , pp. 727-740
    • Shieh, P.B.1    Hu, S.C.2    Bobb, K.3    Timmusk, T.4    Ghosh, A.5
  • 69
    • 44649158877 scopus 로고    scopus 로고
    • Yearly measurements of blood lead in Swedish children since 1978 The declining trend continues in the petrol-lead-free period 1995-2007
    • Stromberg, U., Lundh, T., and Skerfving, S. (2008). Yearly measurements of blood lead in Swedish children since 1978: The declining trend continues in the petrol-lead-free period 1995-2007. Environ. Res. 107, 332-335.
    • (2008) Environ. Res. , vol.107 , pp. 332-335
    • Stromberg, U.1    Lundh, T.2    Skerfving, S.3
  • 70
    • 2942556680 scopus 로고    scopus 로고
    • The synaptic vesicle cycle
    • Sudhof, T. C. (2004). The synaptic vesicle cycle. Annu. Rev. Neurosci. 27, 509-547.
    • (2004) Annu. Rev. Neurosci. , vol.27 , pp. 509-547
    • Sudhof, T.C.1
  • 71
    • 31444453032 scopus 로고    scopus 로고
    • The ups and downs of BDNF in Rett syndrome
    • Sun, Y. E., and Wu, H. (2006). The ups and downs of BDNF in Rett syndrome. Neuron 49, 321-323.
    • (2006) Neuron , vol.49 , pp. 321-323
    • Sun, Y.E.1    Wu, H.2
  • 72
    • 0037183985 scopus 로고    scopus 로고
    • Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I
    • Tabuchi, A., Sakaya, H., Kisukeda, T., Fushiki, H., and Tsuda, M. (2002). Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I. J. Biol. Chem. 277, 35920-35931.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35920-35931
    • Tabuchi, A.1    Sakaya, H.2    Kisukeda, T.3    Fushiki, H.4    Tsuda, M.5
  • 74
    • 0032034262 scopus 로고    scopus 로고
    • Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism
    • Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., and Greenberg, M. E. (1998). Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20, 709-726.
    • (1998) Neuron , vol.20 , pp. 709-726
    • Tao, X.1    Finkbeiner, S.2    Arnold, D.B.3    Shaywitz, A.J.4    Greenberg, M.E.5
  • 75
    • 0037204070 scopus 로고    scopus 로고
    • A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF
    • Tao, X., West, A. E., Chen, W. G., Corfas, G., and Greenberg, M. E. (2002). A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron 33, 383-395.
    • (2002) Neuron , vol.33 , pp. 383-395
    • Tao, X.1    West, A.E.2    Chen, W.G.3    Corfas, G.4    Greenberg, M.E.5
  • 76
    • 0031439983 scopus 로고    scopus 로고
    • Activity-dependent dendritic targeting of BDNF and TrkB mRNAs in hippocampal neurons
    • Tongiorgi, E., Righi, M., and Cattaneo, A. (1997). Activity-dependent dendritic targeting of BDNF and TrkB mRNAs in hippocampal neurons. J. Neurosci. 17, 9492-9505.
    • (1997) J. Neurosci. , vol.17 , pp. 9492-9505
    • Tongiorgi, E.1    Righi, M.2    Cattaneo, A.3
  • 77
    • 27544506060 scopus 로고    scopus 로고
    • Lead neurotoxicity: From exposure to molecular effects
    • Toscano, C. D., and Guilarte, T. R. (2005). Lead neurotoxicity: From exposure to molecular effects. Brain Res. Brain Res. Rev. 49, 529-554.
    • (2005) Brain Res. Brain Res. Rev , vol.49 , pp. 529-554
    • Toscano, C.D.1    Guilarte, T.R.2
  • 78
    • 0037115070 scopus 로고    scopus 로고
    • Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain
    • Toscano, C. D., Hashemzadeh-Gargari, H., McGlothan, J. L., and Guilarte, T. R. (2002). Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain. Brain Res. Dev. Brain Res. 139, 217-226.
    • (2002) Brain Res. Dev Brain Res. , vol.139 , pp. 217-226
    • Toscano, C.D.1    Hashemzadeh-Gargari, H.2    McGlothan, J.L.3    Guilarte, T.R.4
  • 79
    • 0242321219 scopus 로고    scopus 로고
    • Lead exposure alters cyclic-AMP response element binding protein phosphorylation and binding activity in the developing rat brain
    • Toscano, C. D., McGlothan, J. L., and Guilarte, T. R. (2003). Lead exposure alters cyclic-AMP response element binding protein phosphorylation and binding activity in the developing rat brain. Brain Res. Dev. Brain Res. 145, 219-228.
    • (2003) Brain Res. Dev Brain Res. , vol.145 , pp. 219-228
    • Toscano, C.D.1    McGlothan, J.L.2    Guilarte, T.R.3
  • 80
    • 18244391952 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase II activity and expression are altered in the hippocampus of Pb2+-exposed rats
    • Toscano, C. D., O'Callaghan, J. P., and Guilarte, T. R. (2005). Calcium/calmodulin-dependent protein kinase II activity and expression are altered in the hippocampus of Pb2+-exposed rats. Brain Res. 1044, 51-58.
    • (2005) Brain Res , vol.1044 , pp. 51-58
    • Toscano, C.D.1    O'Callaghan, J.P.2    Guilarte, T.R.3
  • 81
    • 0026454799 scopus 로고
    • Developmental change of the inhibition by lead of NMDA-activated currents in cultured hippocampal neurons
    • Ujihara, H., and Albuquerque, E. X. (1992). Developmental change of the inhibition by lead of NMDA-activated currents in cultured hippocampal neurons. J. Pharmacol. Exp. Ther. 263, 868-875.
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 868-875
    • Ujihara, H.1    Albuquerque, E.X.2
  • 83
    • 0036312343 scopus 로고    scopus 로고
    • Bidirectional changes in synapsin I phosphorylation at MAP kinasedependent sites by acute neuronal excitation in vivo
    • Yamagata, Y., Jovanovic, J. N., Czernik, A. J., Greengard, P., and Obata, K. (2002). Bidirectional changes in synapsin I phosphorylation at MAP kinasedependent sites by acute neuronal excitation in vivo. J. Neurochem. 80, 835-842.
    • (2002) J. Neurochem. , vol.80 , pp. 835-842
    • Yamagata, Y.1    Jovanovic, J.N.2    Czernik, A.J.3    Greengard, P.4    Obata, K.5
  • 84
    • 0025889012 scopus 로고
    • Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons
    • Zafra, F., Castren, E., Thoenen, H., and Lindholm, D. (1991). Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons. Proc. Natl. Acad. Sci. U.S.A. 88, 10037-10041.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 10037-10041
    • Zafra, F.1    Castren, E.2    Thoenen, H.3    Lindholm, D.4
  • 85
    • 27344442733 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons
    • Zagrebelsky, M., Holz, A., Dechant, G., Barde, Y. A., Bonhoeffer, T., and Korte, M. (2005). The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons. J. Neurosci. 25, 9989-9999.
    • (2005) J. Neurosci. , vol.25 , pp. 9989-9999
    • Zagrebelsky, M.1    Holz, A.2    Dechant, G.3    Barde, Y.A.4    Bonhoeffer, T.5    Korte, M.6
  • 86
    • 57049184027 scopus 로고    scopus 로고
    • Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons
    • Zala, D., Colin, E., Rangone, H., Liot, G., Humbert, S., and Saudou, F. (2008). Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons. Hum. Mol. Genet. 17, 3837-3846.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 3837-3846
    • Zala, D.1    Colin, E.2    Rangone, H.3    Liot, G.4    Humbert, S.5    Saudou, F.6
  • 87
    • 47849091540 scopus 로고    scopus 로고
    • Blood lead and cadmium levels and relevant factors among children from an e-waste recycling town in China
    • Zheng, L., Wu, K., Li, Y., Qi, Z., Han, D., Zhang, B., Gu, C., Chen, G., Liu, J., Chen, S., et al. (2008). Blood lead and cadmium levels and relevant factors among children from an e-waste recycling town in China. Environ. Res. 108, 15-20.
    • (2008) Environ. Res. , vol.108 , pp. 15-20
    • Zheng, L.1    Wu, K.2    Li, Y.3    Qi, Z.4    Han, D.5    Zhang, B.6    Gu, C.7    Chen, G.8    Liu, J.9    Chen, S.10
  • 88
    • 33749590330 scopus 로고    scopus 로고
    • Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation
    • Zhou, Z., Hong, E. J., Cohen, S., Zhao, W. N., Ho, H. Y., Schmidt, L., Chen, W. G., Lin, Y., Savner, E., Griffith, E. C., et al. (2006). Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 52, 255-269.
    • (2006) Neuron , vol.52 , pp. 255-269
    • Zhou, Z.1    Hong, E.J.2    Cohen, S.3    Zhao, W.N.4    Ho, H.Y.5    Schmidt, L.6    Chen, W.G.7    Lin, Y.8    Savner, E.9    Griffith, E.C.10
  • 89
    • 34047130812 scopus 로고    scopus 로고
    • Role of brain-derived neurotrophic factor in Huntington's disease
    • Zuccato, C., and Cattaneo, E. (2007). Role of brain-derived neurotrophic factor in Huntington's disease. Prog. Neurobiol. 81, 294-330.
    • (2007) Prog. Neurobiol. , vol.81 , pp. 294-330
    • Zuccato, C.1    Cattaneo, E.2


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