Monitoring disease evolution and treatment response in lysosomal disorders by the peripheral benzodiazepine receptor ligand PK11195

Neurobiology of Disease

Volumn 34, Issue 1, 2009, Pages 51-62

  Visigalli, Ilaria ^a,b   Moresco, Rosa Maria ^c,e,f   Belloli, Sara ^c,e,f   Politi, Letterio S ^b,d   Gritti, Angela ^a   Ungaro, Daniela ^c   Matarrese, Mario ^c,e,f   Turolla, Elia ^c,e,f   Falini, Andrea ^b,d   Scotti, Giuseppe ^b,d   Naldini, Luigi ^a,b   Fazio, Ferruccio ^c,f   Biffi, Alessandra ^a,b  

^a SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d Neuroradiology Department   (Italy)

^e INSTITUTE OF MOLECULAR BIOIMAGING AND PHYSIOLOGY   (Italy)

^f UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Hematopoietic stem cell transplantation; Lysosomal storage disorders; Microglia; Neuroinflammation; Peripheral benzodiazepine receptor ligands; Positron emission tomography

Indexed keywords

BENZODIAZEPINE RECEPTOR; CARBON 11; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE CARBON 11; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG RECEPTOR BINDING; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMAGE ANALYSIS; LYSOSOME STORAGE DISEASE; MICROGLIA; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; CENTRAL NERVOUS SYSTEM DISEASES; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; GLIOSIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; ISOQUINOLINES; LIGANDS; LYSOSOMAL STORAGE DISEASES, NERVOUS SYSTEM; MICE; MICE, TRANSGENIC; MICROGLIA; MICROSCOPY, CONFOCAL; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, GABA-A;

EID: 62149152389     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2008.12.019     Document Type: Article

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