Conditional expression of human β-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation

Journal of Neuroinflammation

Volumn 9, Issue , 2012, Pages

  Kyrkanides, Stephanos ^a   Brouxhon, Sabine M ^a   Tallents, Ross H ^b   Miller, Jen nie H ^b   Olschowka, John A ^b   O'Banion, M K ^b  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Mouse; Neuron; Sandhoff disease; Transgenic; hexosaminidase

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; CASPASE 3; CD45 ANTIGEN; CYCLOOXYGENASE 2; GANGLIOSIDE GM2; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; THY 1 ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BETA HEXOSAMINIDASE GENE; CONTROLLED STUDY; CYCLOOXYGENASE 2 GENE; ENCEPHALITIS; GENE; GENE EXPRESSION; GLIAL FIBRILLARY ACIDIC PROTEIN GENE; HUMAN; IMMUNOREACTIVITY; INTERLEUKIN 1BETA GENE; MACROPHAGE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2 GENE; MICROGLIA; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; SANDHOFF DISEASE; TRANSGENE; TUMOR NECROSIS FACTOR ALPHA GENE;

EID: 84864503947     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-186     Document Type: Article

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