Radioiodinated DPA-713 imaging correlates with bactericidal activity of tuberculosis treatments in mice

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 1, 2015, Pages 642-649

  Ordonez, Alvaro A ^a   Pokkali, Supriya ^a   DeMarco, Vincent P ^a   Klunk, Mariah ^a   Mease, Ronnie C ^a   Foss, Catherine A ^a   Pomper, Martin G ^a   Jain, Sanjay K ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEDAQUILINE; CLOFAZIMINE; DPA 713 I 124; DPA 713 I 125; FLUORODEOXYGLUCOSE F 18; GAMMA INTERFERON; IODINE 125; ISONIAZID; PYRAZINAMIDE; RADIOPHARMACEUTICAL AGENT; RIFAMPICIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ACETAMIDE DERIVATIVE; CYTOKINE; N,N-DIETHYL-2-(2-(4-METHOXYPHENYL)-5,7-DIMETHYL-PYRAZOLO(1,5-A)PYRIMIDIN-3-YL)-ACETAMIDE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; QUINOLINE DERIVATIVE; RADIOACTIVE IODINE; TUBERCULOSTATIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERICIDAL ACTIVITY; C3HEB/FE MOUSE; CONTROLLED STUDY; CT SPECT SCANNER; CYTOKINE RESPONSE; EX VIVO STUDY; FEMALE; LUNG GRANULOMA; LUNG TUBERCULOSIS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOIODINATION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ANIMAL; C3H MOUSE; DIAGNOSTIC IMAGING; DISEASE MODEL; LUNG; METABOLISM; PATHOGENICITY; PATHOLOGY; PROCEDURES; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; TUBERCULOSIS;

ACETAMIDES; ANIMALS; ANTITUBERCULAR AGENTS; CYTOKINES; DIAGNOSTIC IMAGING; DIARYLQUINOLINES; DISEASE MODELS, ANIMAL; FEMALE; FLUORODEOXYGLUCOSE F18; IODINE RADIOISOTOPES; LUNG; MICE, INBRED C3H; MYCOBACTERIUM TUBERCULOSIS; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TUBERCULOSIS;

EID: 84920162525     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.04180-14     Document Type: Article

References (36)

1. Dye C, Williams BG. 2008. Eliminating human tuberculosis in the twentyfirst century. J R Soc Interface 5:653-662. http://dx.doi.org/10.1098/rsif.2007 .1138.
2. Boehme CC, Nabeta P, Hillemann D, Nicol MP, Shenai S, Krapp F, Allen J, Tahirli R, Blakemore R, Rustomjee R, Milovic A, Jones M, O'Brien SM, Persing DH, Ruesch-Gerdes S, Gotuzzo E, Rodrigues C, Alland D, Perkins MD. 2010. Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med 363:1005-1015. http://dx.doi.org /10.1056/NEJMoa0907847.
3. Centers for Disease Control and Prevention. 2006. Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs-worldwide, 2000-2004.MMWRMorb Mortal Wkly Rep 55:301-305. http: //dx.doi.org/10.1037/e566482006-002.
4. Velayati AA, Masjedi MR, Farnia P, Tabarsi P, Ghanavi J, Ziazarifi AH, Hoffner SE. 2009. Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in Iran. Chest 136:420-425. http://dx.doi.org/10 .1378/chest.08-2427.
5. Davis SL, Nuermberger EL, Um PK, Vidal C, Jedynak B, Pomper MG, Bishai WR, Jain SK. 2009. Noninvasive pulmonary [18 F]-2-fluoro-deoxy-D-glucose positron emission tomography correlates with bactericidal activity of tuberculosis drug treatment. Antimicrob Agents Chemother 53:4879-4884. http://dx.doi.org/10.1128/AAC.00789-09.
6. Sathekge M, Maes A, Kgomo M, Stoltz A, Van de Wiele C. 2011. Use of 18F-FDG PET to predict response to first-line tuberculostatics in HIVassociated tuberculosis. J Nucl Med 52:880-885. http://dx.doi.org/10 .2967/jnumed.110.083709.
7. Coleman MT, Maiello P, Tomko J, Frye LJ, Fillmore D, Janssen C, Klein E, Lin PL. 2014. Early changes by (18)fluorodeoxyglucose positron emission tomography coregistered with computed tomography predict outcome after Mycobacte-rium tuberculosis infection in cynomolgus macaques. Infect Immun 82:2400-2404. http://dx.doi.org/10.1128/IAI.01599-13.
8. Via LE, Schimel D, Weiner DM, Dartois V, Dayao E, Cai Y, Yoon YS, Dreher MR, Kastenmayer RJ, Laymon CM, Carny JE, Flynn JL, Herscovitch P, Barry CE, 3rd. 2012. Infection dynamics and response to chemotherapy in a rabbit model of tuberculosis using [18F]2-fluoro-deoxy-D-glucose positron emission tomography and computed tomography. Antimicrob Agents Chemother 56:4391-4402. http://dx.doi.org/10 .1128/AAC.00531-12.
9. Bell GI, Burant CF, Takeda J, Gould GW. 1993. Structure and function of mammalian facilitative sugar transporters. J Biol Chem 268:19161-19164.
10. Pauwels EK, Ribeiro MJ, Stoot JH, McCready VR, Bourguignon M, Maziere B. 1998. FDG accumulation and tumor biology. Nucl Med Biol 25:317-322. http://dx.doi.org/10.1016/S0969-8051(97)00226-6.
11. Zhuang H, Alavi A. 2002. 18-Fluorodeoxyglucose positron emission tomographic imaging in the detection and monitoring of infection and inflammation. Semin Nucl Med 32:47-59. http://dx.doi.org/10.1053/snuc .2002.29278.
12. Rupprecht R, Papadopoulos V, Rammes G, Baghai TC, Fan J, Akula N, Groyer G, Adams D, Schumacher M. 2010. Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov 9:971-988. http://dx.doi.org/10.1038 /nrd3295.
13. Zavala F, Haumont J, Lenfant M. 1984. Interaction of benzodiazepines with mouse macrophages. Eur J Pharmacol 106:561-566. http://dx.doi .org/10.1016/0014-2999(84)90059-1.
14. Foss CA, Harper JS, Wang H, Pomper MG, Jain SK. 2013. Noninvasive molecular imaging of tuberculosis-associated inflammation with radioiodinated DPA-713. J Infect Dis 208:2067-2074. http://dx.doi.org/10.1093 /infdis/jit331.
15. Diacon AH, Pym A, Grobusch M, Patientia R, Rustomjee R, Page-Shipp L, Pistorius C, Krause R, Bogoshi M, Churchyard G, Venter A, Allen J, Palomino JC, De Marez T, van Heeswijk RP, Lounis N, Meyvisch P, Verbeeck J, Parys W, de Beule K, Andries K, Mc Neeley DF. 2009. The diarylquinoline TMC207 for multidrug-resistant tuberculosis. N Engl J Med 360:2397-2405. http://dx.doi.org/10.1056/NEJMoa0808427.
16. Harper J, Skerry C, Davis SL, Tasneen R, Weir M, Kramnik I, Bishai WR, Pomper MG, Nuermberger EL, Jain SK. 2012. Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions. J Infect Dis 205:595-602. http://dx.doi.org/10.1093/infdis/jir786.
17. Pan H, Yan BS, Rojas M, Shebzukhov YV, Zhou H, Kobzik L, Higgins DE, Daly MJ, Bloom BR, Kramnik I. 2005. Ipr1 gene mediates innate immunity to tuberculosis. Nature 434:767-772. http://dx.doi.org/10.1038 /nature03419.
18. Wang H, Pullambhatla M, Guilarte TR, Mease RC, Pomper MG. 2009. Synthesis of [125I]iodoDPA-713: a new probe for imaging inflammation. Biochem Biophys Res Commun 389:80-83. http://dx.doi.org/10.1016/j .bbrc.2009.08.102.
19. Davis SL, Be NA, Lamichhane G, Nimmagadda S, Pomper MG, Bishai WR, Jain SK. 2009. Bacterial thymidine kinase as a non-invasive imaging reporter for Mycobacterium tuberculosis in live animals. PLoS One 4:e6297. http://dx.doi.org/10.1371/journal.pone.0006297.
20. Liu F, Whitton JL. 2005. Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections. J Immunol 174:5936-5940. http://dx.doi.org/10.4049/jimmunol.174.10 .5936.
21. Bhatt K, Kim A, Kim A, Mathur S, Salgame P. 2013. Equivalent functions for B7.1 and B7.2 costimulation in mediating host resistance to Mycobacterium tuberculosis. Cell Immunol 285:69-75. http://dx.doi.org/10 .1016/j.cellimm.2013.09.004.
22. Tasneen R, Li SY, Peloquin CA, Taylor D, Williams KN, Andries K, Mdluli KE, Nuermberger EL. 2011. Sterilizing activity of novel TMC207-and PA-824-containing regimens in a murine model of tuberculosis. Antimicrob Agents Chemother 55:5485-5492. http://dx.doi.org/10.1128 /AAC.05293-11.
23. Dayan D, Hiss Y, Hirshberg A, Bubis JJ, Wolman M. 1989. Are the polarization colors of picrosirius red-stained collagen determined only by the diameter of the fibers? Histochemistry 93:27-29. http://dx.doi.org/10 .1007/BF00266843.
24. Driver ER, Ryan GJ, Hoff DR, Irwin SM, Basaraba RJ, Kramnik I, Lenaerts AJ. 2012. Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis. Antimicrob Agents Chemother 56:3181-3195. http: //dx.doi.org/10.1128/AAC.00217-12.
25. Wallis RS, Kim P, Cole S, Hanna D, Andrade BB, Maeurer M, Schito M, Zumla A. 2013. Tuberculosis biomarkers discovery: developments, needs, and challenges. Lancet Infect Dis 13:362-372. http://dx.doi.org/10.1016 /S1473-3099(13)70034-3.
26. Fenton MJ, Vermeulen MW. 1996. Immunopathology of tuberculosis: roles of macrophages and monocytes. Infect Immun 64:683-690.
27. Canetti G. 1965. Present aspects of bacterial resistance in tuberculosis.Am Rev Respir Dis 92:687-703.
28. th ed. Saunders/Elsevier, Philadelphia, PA.
29. Johnson DH, Via L, Kim P, Laddy D, Lau C-Y, Weinstein EA, Jain S. 2014. Nuclear imaging: a powerful novel approach for tuberculosis. Nucl Med Biol 41:777-784. http://dx.doi.org/10.1016/j.nucmedbio.2014.08 .005.
30. Ordonez AA, Pokkali S, Mease R, Klunk M, Foss CA, Pomper MG, Jain SK. 2014. Characterization of iodo-DPA-713 imaging in mice receiving novel TB treatments, abstr 3002, p 78. In Novel therapeutic approaches to tuberculosis. Keystone Symposia Conference, Keystone, CO.
31. Nuermberger E, Jain SK, Tasneen R. 2014. Cavitary TB in C3HeB/FeJ mice, abstr 2047, p 75. In Novel therapeutic approaches to tuberculosis. Keystone Symposia Conference, Keystone, CO.
32. Russell DG, Cardona PJ, Kim MJ, Allain S, Altare F. 2009. Foamy macrophages and the progression of the human tuberculosis granuloma. Nat Immunol 10:943-948. http://dx.doi.org/10.1038/ni.1781.
33. Gottfried E, Kunz-Schughart LA, Weber A, Rehli M, Peuker A, Muller A, Kastenberger M, Brockhoff G, Andreesen R, Kreutz M. 2008. Expression of CD68 in non-myeloid cell types. Scand J Immunol 67:453-463. http://dx.doi.org/10.1111/j.1365-3083.2008.02091.x.
34. Amanzada A, Malik IA, Blaschke M, Khan S, Rahman H, Ramadori G, Moriconi F. 2013. Identification of CD68(+) neutrophil granulocytes in in vitro model of acute inflammation and inflammatory bowel disease. Int J Clin Exp Pathol 6:561-570. http://dx.doi.org/10.1055/s-0033-1352657.
35. Gabrilovich DI, Nagaraj S. 2009. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9:162-174. http://dx .doi.org/10.1038/nri2506.
36. Hickman SP, Chan J, Salgame P. 2002. Mycobacterium tuberculosis induces differential cytokine production from dendritic cells and macrophages with divergent effects on naive T cell polarization. J Immunol 168:4636-4642. http://dx.doi.org/10.4049/jimmunol.168.9.4636.