The use of porcupine inhibitors to target Wnt-driven cancers

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 23, 2015, Pages 5472-5476

  Ho, Soo Yei ^a   Keller, Thomas H ^a  

^a Agency for Science   (Singapore)

Author keywords

Acyltransferase; Palmitoleation; Phenotypic assays; Porcupine inhibitors; Wnt driven cancers; Wnt signalling pathway

Indexed keywords

ACYLTRANSFERASE INHIBITOR; ANTINEOPLASTIC AGENT; BENZOTHIAZOLE; C 59; ETC 130; ETC 131; ETC 159; GNF 1331; IWP L 6; LGK 974; PORCUPINE INHIBITOR; UNCLASSIFIED DRUG; WNT PROTEIN; BENZOTHIAZOLE DERIVATIVE; IWP-1 COMPOUND; IWP-2 COMPOUND; MEMBRANE PROTEIN; PORCN PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; HEK293 CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; IC50; LOSS OF FUNCTION MUTATION; NEOPLASM; NONHUMAN; PANCREAS CANCER; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; WNT SIGNALING PATHWAY; XENOPUS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; NEOPLASMS;

ANIMALS; BENZOTHIAZOLES; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MOLECULAR STRUCTURE; NEOPLASMS; WNT SIGNALING PATHWAY;

EID: 84946721214     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.10.032     Document Type: Review

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