Discovery and Optimization of a Porcupine Inhibitor

Journal of Medicinal Chemistry

Volumn 58, Issue 15, 2015, Pages 5889-5899

  Duraiswamy, Athisayamani Jeyaraj ^a,c   Lee, May Ann ^a   Madan, Babita ^b   Ang, Shi Hua ^a   Tan, Eldwin Sum Wai ^a   Cheong, Wei Wen Vivien ^a   Ke, Zhiyuan ^a   Pendharkar, Vishal ^a   Ding, Li Jun ^a   Chew, Yun Shan ^a   Manoharan, Vithya ^a   Sangthongpitag, Kanda ^a   Alam, Jenefer ^a   Poulsen, Anders ^a   Ho, Soo Yei ^a   Virshup, David M ^b   Keller, Thomas H ^a  

^a Agency for Science   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c GVK BIOSCIENCES PVT LTD   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 (1H IMIDAZOL 1 YL)PHENYL] N (BIPHENYL 4 YL)PYRROLIDINE 2 CARBOXAMIDE; 2 [4 (1H IMIDAZOL 1 YL)PHENOXY] N (BIPHENYL 4 YL)PROPANAMIDE; 2 [4 (1H IMIDAZOL 1 YL)PHENOXY] N [(1,1' BIPHENYL) 4 YL]ACETAMIDE; 2 [4 (1H IMIDAZOL 1 YL)PHENYLAMINO] N (5 PHENYLPYRIDIN 2 YL)PROPANAMIDE; 2 [4 (1H PYRAZOL 3 YL)PHENOXY] N (BIPHENYL 4 YL)ACETAMIDE; 2 [4 (1H PYRROL 1 YL)PHENOXY] N (BIPHENYL 4 YL)ACETAMIDE; 2 [6 (1 METHYL 1H PYRAZOL 5 YL)PYRIDIN 3 YLAMINO] N (5 PHENYLPYRIDIN 2 YL)PROPANAMIDE; 2 [[4 (1H IMIDAZOL 1 YL)PHENYL]AMINO] N [(1,1' BIPHENYL) 4 YL]ACETAMIDE; ACYLTRANSFERASE INHIBITOR; BETA CATENIN; C 59; N (2,3' BIPYRIDIN 5 YL) 2 [6 (1 METHYL 1H PYRAZOL 5 YL)PYRIDIN 3 YLAMINO]PROPANAMIDE; N (3,3' BIPYRIDIN 6 YL) 2 [6 (1 METHYL 1H PYRAZOL 5 YL)PYRIDIN 3 YLAMINO]PROPANAMIDE; N (BIPHENYL 4 YL) 2 [4 (1 METHYL 1H PYRAZOL 5 YL)PHENOXY]ACETAMIDE; N (BIPHENYL 4 YL) 2 [4 (2 METHYL 1H IMIDAZOL 1 YL)PHENOXY]ACETAMIDE; N (BIPHENYL 4 YL) 2 [4 (OXAZOL 5 YL)PHENOXY]ACETAMIDE; PORCUPINE INHIBITOR; UNCLASSIFIED DRUG; WNT PROTEIN; ENZYME INHIBITOR; MEMBRANE PROTEIN; PORCN PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENANTIOMER; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PROCESS OPTIMIZATION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PALMITOLEATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TUMOR MODEL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; WNT SIGNALING PATHWAY;

DRUG DISCOVERY; ENZYME INHIBITORS; MEMBRANE PROTEINS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; WNT SIGNALING PATHWAY;

EID: 84939202237     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00507     Document Type: Article

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