Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells

Radiation Oncology

Volumn 10, Issue 1, 2015, Pages

  Ma, Hongyu ^a   Takahashi, Akihisa ^b   Yoshida, Yukari ^b   Adachi, Akiko ^a   Kanai, Tatsuaki ^b   Ohno, Tatsuya ^b   Nakano, Takashi ^a,b  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b GUNMA UNIVERSITY HEAVY ION MEDICAL CENTER   (Japan)

Author keywords

Carbon ion irradiation; DNA double strand breaks; Homologous recombination repair; Non homologous end joining repair; Radiosensitization

Indexed keywords

ANTINEOPLASTIC AGENT; B 02; CARBON; HISTONE H2AX; NU 7026; RAD51 PROTEIN; UNCLASSIFIED DRUG; 2-(MORPHOLIN-4-YL)BENZO(H)CHROMEN-4-ONE; CHROMONE DERIVATIVE; MORPHOLINE DERIVATIVE; RADIOSENSITIZING AGENT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RADIOTHERAPY; CELL SURVIVAL; COLONY FORMING UNIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA END JOINING REPAIR; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NON SMALL CELL LUNG CANCER; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; RADIOSENSITIZATION; STAINING; DRUG EFFECTS; ION THERAPY; LUNG TUMOR; PATHOLOGY; PROCEDURES; RADIATION RESPONSE; RADIATION TOLERANCE; TUMOR CELL LINE;

CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CHROMONES; DNA END-JOINING REPAIR; HEAVY ION RADIOTHERAPY; HUMANS; LUNG NEOPLASMS; MORPHOLINES; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS;

EID: 84946575296     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/s13014-015-0536-z     Document Type: Article

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