Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation

Radiotherapy and Oncology

Volumn 116, Issue 3, 2015, Pages 374-380

  Fontana, Andrea O ^a   Augsburger, Marc A ^a   Grosse, Nicole ^a   Guckenberger, Matthias ^a   Lomax, Anthony J ^c   Sartori, Alessandro A ^b   Pruschy, Martin N ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

Homologous recombination; Non homologous end joining; NU7026; Photon irradiation; Proton irradiation

Indexed keywords

HISTONE H2AX; PROTEIN INHIBITOR; RAD51 PROTEIN; PROTON;

CANCER CELL; CELL SURVIVAL; CLONOGENESIS; CONFERENCE PAPER; CONTROLLED STUDY; DNA DAMAGE; DNA END JOINING REPAIR; DNA REPAIR; DOSIMETRY; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; GLIOBLASTOMA; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IRRADIATION; LINEAR ENERGY TRANSFER; LUNG ADENOCARCINOMA; OVARY CARCINOMA; PHOTON IRRADIATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTON RADIATION; RADIOSENSITIVITY; RADIOSENSITIZATION; TREATMENT RESPONSE; WESTERN BLOTTING; ADENOCARCINOMA; LUNG NEOPLASMS; PHYSIOLOGY; RADIATION RESPONSE; RADIATION TOLERANCE; TUMOR CELL LINE;

ADENOCARCINOMA; CELL LINE, TUMOR; CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA REPAIR; GLIOBLASTOMA; HUMANS; LUNG NEOPLASMS; PROTONS; RADIATION TOLERANCE;

EID: 84944147599     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2015.08.014     Document Type: Conference Paper

References (19)

1. D. De Ruysscher, M. Mark Lodge, B. Jones, and et al. Charged particles in radiotherapy: a 5-year update of a systematic review Radiother Oncol 103 2012 5 7
2. H. Paganetti, A. Niemierko, M. Ancukiewicz, and et al. Relative biological effectiveness (RBE) values for proton beam therapy Int J Radiat Oncol Biol Phys 53 2002 407 421
3. M.R. Raju Proton radiobiology, radiosurgery and radiotherapy Int J Radiat Biol 67 1995 237 259
4. A. Cometto, G. Russo, F. Bourhaleb, and et al. Direct evaluation of radiobiological parameters from clinical data in the case of ion beam therapy: an alternative approach to the relative biological effectiveness Phys Med Biol 59 2014 7393 7417
5. H. Paganetti Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer Phys Med Biol 59 2014 R419 R472
6. F. Tommasino, and M. Durante Proton radiobiology Cancers 7 2015 353 381
7. A. Gerelchuluun, E. Manabe, T. Ishikawa, and et al. The major DNA repair pathway after both proton and carbon-ion radiation is NHEJ, but the HR pathway is more relevant in carbon ions Radiat Res 183 2015 345 356
8. N. Grosse, A.O. Fontana, E.B. Hug, and et al. Deficiency in homologous recombination renders mammalian cells more sensitive to proton versus photon irradiation Int J Radiat Oncol Biol Phys 88 2014 175 181
9. K. Koch, A. Wrona, E. Dikomey, and K. Borgmann Impact of homologous recombination on individual cellular radiosensitivity Radiother Oncol 90 2009 265 272
10. M. Shrivastav, C.A. Miller, L.P. De Haro, and et al. DNA-PKcs and ATM co-regulate DNA double-strand break repair DNA Repair (Amst) 8 2009 920 929
11. P.A. Jeggo, V. Geuting, and M. Lobrich The role of homologous recombination in radiation-induced double-strand break repair Radiother Oncol 101 2011 7 12
12. M.R. Lieber The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway Annu Rev Biochem 79 2010 181 211
13. L.F. Povirk Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks DNA Repair (Amst) 5 2006 1199 1212
14. E. Pedroni, R. Bacher, H. Blattmann, and et al. The 200-Mev proton therapy project at the Paul-Scherrer-Institute - conceptual design and practical realization Med Phys 22 1995 37 53
15. N.A. Franken, H.M. Rodermond, J. Stap, J. van Haveman, and C. Bree Clonogenic assay of cells in vitro Nat Protoc 1 2006 2315 2319
16. A. Staab, D. Zukowski, S. Walenta, M. Scholz, and W. Mueller-Klieser Response of Chinese hamster v79 multicellular spheroids exposed to high-energy carbon ions Radiat Res 161 2004 219 227
17. C. Allen, J. Halbrook, and J.A. Nickoloff Interactive competition between homologous recombination and non-homologous end joining Mol Cancer Res 1 2003 913 920
18. M.J. Allalunis-Turner, G.M. Barron, R.S. Day 3rd, K.D. Dobler, and R. Mirzayans Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs Radiat Res 134 1993 349 354
19. X. Chen, P. Wong, E.H. Radany, J.M. Stark, C. Laulier, and J.Y. Wong Suberoylanilide hydroxamic acid as a radiosensitizer through modulation of RAD51 protein and inhibition of homology-directed repair in multiple myeloma Mol Cancer Res 10 2012 1052 1064