Suppression of DNA-dependent protein kinase sensitize cells to radiation without affecting DSB repair

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 769, Issue , 2014, Pages 1-10

  Gustafsson, Ann Sofie ^a   Abramenkovs, Andris ^a   Stenerlöw, Bo ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

DNA repair; DNA PK deficiency; DNA PKcs; Ionizing radiation; NU7441

Indexed keywords

BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; HISTONE H2AX; NU 7441; P53 BINDING PROTEIN1; PROTEIN SERINE THREONINE KINASE INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 8-DIBENZOTHIOPHEN-4-YL-2-MORPHOLIN-4-YL-CHROMEN-4-ONE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; MORPHOLINE DERIVATIVE; RADIOSENSITIZING AGENT;

ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL FRACTIONATION; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; G2 PHASE CELL CYCLE CHECKPOINT; GENE REPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IONIZING RADIATION; MITOSIS; PRIORITY JOURNAL; RADIOSENSITIVITY; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HCT116 CELL LINE; METABOLISM; RADIATION DOSE; RADIATION RESPONSE;

CELL SURVIVAL; CELLS, CULTURED; CHROMONES; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HCT116 CELLS; HUMANS; MITOSIS; MORPHOLINES; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; RNA, SMALL INTERFERING;

EID: 84904763403     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2014.06.004     Document Type: Article

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