메뉴 건너뛰기




Volumn 45, Issue , 2015, Pages 87-96

Biomarker-driven diagnosis of diffuse gliomas

Author keywords

1p 19q; Astrocytoma; ATRX; Biomarker; BRAF; EGFR; Glioblastoma; Glioma; H3F3A; IDH; Oligodendroglioma; TERT; TP53

Indexed keywords

ISOCITRATE DEHYDROGENASE; TUMOR MARKER; B RAF KINASE; BRAF PROTEIN, HUMAN; CIC PROTEIN, HUMAN; DNA BINDING PROTEIN; DNA HELICASE; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; FUBP1 PROTEIN, HUMAN; NOTCH1 PROTEIN, HUMAN; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53; PTEN PROTEIN, HUMAN; REPRESSOR PROTEIN; TELOMERASE; TERT PROTEIN, HUMAN; TP53 PROTEIN, HUMAN;

EID: 84946492585     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2015.05.002     Document Type: Review
Times cited : (73)

References (87)
  • 1
    • 33846981845 scopus 로고    scopus 로고
    • Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma
    • K. Aldape, P.C. Burger, and A. Perry Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma Arch. Pathol. Lab. Med 131 2 2007 242 251
    • (2007) Arch. Pathol. Lab. Med , vol.131 , Issue.2 , pp. 242-251
    • Aldape, K.1    Burger, P.C.2    Perry, A.3
  • 2
    • 84893519542 scopus 로고    scopus 로고
    • Molecular genetics of gliomas
    • C.L. Appin, and D.J. Brat Molecular genetics of gliomas Cancer J. 20 1 2014 66 72
    • (2014) Cancer J. , vol.20 , Issue.1 , pp. 66-72
    • Appin, C.L.1    Brat, D.J.2
  • 3
    • 84879225414 scopus 로고    scopus 로고
    • Glioblastoma with oligodendroglioma component (GBM-O): Molecular genetic and clinical characteristics
    • C.L. Appin, Gao J., C. Chisolm, and et al. Glioblastoma with oligodendroglioma component (GBM-O): molecular genetic and clinical characteristics Brain Pathol 23 4 2013 454 461
    • (2013) Brain Pathol , vol.23 , Issue.4 , pp. 454-461
    • Appin, C.L.1    Gao, J.2    Chisolm, C.3
  • 6
    • 80052608062 scopus 로고    scopus 로고
    • Mutations in CIC and FUBP1 contribute to human oligodendroglioma
    • C. Bettegowda, N. Agrawal, Jiao Y., and et al. Mutations in CIC and FUBP1 contribute to human oligodendroglioma Science 333 6048 2011 1453 1455
    • (2011) Science , vol.333 , Issue.6048 , pp. 1453-1455
    • Bettegowda, C.1    Agrawal, N.2    Jiao, Y.3
  • 7
    • 0032601042 scopus 로고    scopus 로고
    • Morphologic and molecular genetic aspects of oligodendroglial neoplasms
    • S.H. Bigner, B.K. Rasheed, R. Wiltshire, and R.E. McLendon Morphologic and molecular genetic aspects of oligodendroglial neoplasms Neuro-Oncol 1 1 1999 52 60
    • (1999) Neuro-Oncol , vol.1 , Issue.1 , pp. 52-60
    • Bigner, S.H.1    Rasheed, B.K.2    Wiltshire, R.3    McLendon, R.E.4
  • 8
    • 78649906555 scopus 로고    scopus 로고
    • Update on molecular findings, management and outcome in low-grade gliomas
    • T.D. Bourne, and D. Schiff Update on molecular findings, management and outcome in low-grade gliomas Nat. Rev. Neurol 6 12 2010 695 701
    • (2010) Nat. Rev. Neurol , vol.6 , Issue.12 , pp. 695-701
    • Bourne, T.D.1    Schiff, D.2
  • 9
    • 50449092000 scopus 로고    scopus 로고
    • Diagnosis of malignant glioma: Role of neuropathology
    • D.J. Brat, R.A. Prayson, T.C. Ryken, and J.J. Olson Diagnosis of malignant glioma: role of neuropathology J. Neurooncol 89 3 2008 287 311
    • (2008) J. Neurooncol , vol.89 , Issue.3 , pp. 287-311
    • Brat, D.J.1    Prayson, R.A.2    Ryken, T.C.3    Olson, J.J.4
  • 10
    • 84941627126 scopus 로고    scopus 로고
    • Template for reporting results of biomarker testing of specimens from patients with tumors of the central nervous system
    • D.J. Brat, P.T. Cagle, D.A. Dillon, and et al. Template for reporting results of biomarker testing of specimens from patients with tumors of the central nervous system Arch. Pathol. Lab. Med 2015 10.5858/arpa.2014-0588-CP
    • (2015) Arch. Pathol. Lab. Med
    • Brat, D.J.1    Cagle, P.T.2    Dillon, D.A.3
  • 11
    • 22344447421 scopus 로고    scopus 로고
    • Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas
    • M. Brell, A. Tortosa, E. Verger, and et al. Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas Clin. Cancer Res 11 14 2005 5167 5174
    • (2005) Clin. Cancer Res , vol.11 , Issue.14 , pp. 5167-5174
    • Brell, M.1    Tortosa, A.2    Verger, E.3
  • 12
    • 84885074034 scopus 로고    scopus 로고
    • The somatic genomic landscape of glioblastoma
    • C.W. Brennan, R.G. Verhaak, A. McKenna, and et al. The somatic genomic landscape of glioblastoma Cell 155 2 2013 462 477
    • (2013) Cell , vol.155 , Issue.2 , pp. 462-477
    • Brennan, C.W.1    Verhaak, R.G.2    McKenna, A.3
  • 13
    • 3442878125 scopus 로고    scopus 로고
    • Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas
    • D.K. Broderick, Di C., T.J. Parrett, and et al. Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas Cancer Res 64 15 2004 5048 5050
    • (2004) Cancer Res , vol.64 , Issue.15 , pp. 5048-5050
    • Broderick, D.K.1    Di, C.2    Parrett, T.J.3
  • 14
    • 84882666887 scopus 로고    scopus 로고
    • Distinct phenotypic differences associated with differential amplification of receptor tyrosine kinase genes at 4q12 in glioblastoma
    • A. Burford, S.E. Little, A. Jury, and et al. Distinct phenotypic differences associated with differential amplification of receptor tyrosine kinase genes at 4q12 in glioblastoma PLoS ONE 8 8 2013 e71777
    • (2013) PLoS ONE , vol.8 , Issue.8 , pp. e71777
    • Burford, A.1    Little, S.E.2    Jury, A.3
  • 15
    • 71549122009 scopus 로고    scopus 로고
    • Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors
    • D. Capper, S. Weissert, J. Balss, and et al. Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors Brain Pathol 20 1 2010 245 254
    • (2010) Brain Pathol , vol.20 , Issue.1 , pp. 245-254
    • Capper, D.1    Weissert, S.2    Balss, J.3
  • 16
    • 84877299145 scopus 로고    scopus 로고
    • The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
    • K.M. Chan, Fang D., Gan H., and et al. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression Genes Dev 27 9 2013 985 990
    • (2013) Genes Dev , vol.27 , Issue.9 , pp. 985-990
    • Chan, K.M.1    Fang, D.2    Gan, H.3
  • 17
    • 0030903111 scopus 로고    scopus 로고
    • Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas
    • S.W. Coons, P.C. Johnson, B.W. Scheithauer, A.J. Yates, and D.K. Pearl Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas Cancer 79 7 1997 1381 1393
    • (1997) Cancer , vol.79 , Issue.7 , pp. 1381-1393
    • Coons, S.W.1    Johnson, P.C.2    Scheithauer, B.W.3    Yates, A.J.4    Pearl, D.K.5
  • 18
    • 84907998639 scopus 로고    scopus 로고
    • Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas
    • J.B. Cryan, S. Haidar, L.A. Ramkissoon, and et al. Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas Oncotarget 5 18 2014 8083 8092
    • (2014) Oncotarget , vol.5 , Issue.18 , pp. 8083-8092
    • Cryan, J.B.1    Haidar, S.2    Ramkissoon, L.A.3
  • 19
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • Dang L., D.W. White, S. Gross, and et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature 462 7274 2009 739 744
    • (2009) Nature , vol.462 , Issue.7274 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3
  • 20
    • 79953184268 scopus 로고    scopus 로고
    • BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: Diagnostic and therapeutic implications
    • D. Dias-Santagata, Q. Lam, K. Vernovsky, and et al. BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications PLoS ONE 6 3 2011 e17948
    • (2011) PLoS ONE , vol.6 , Issue.3 , pp. e17948
    • Dias-Santagata, D.1    Lam, Q.2    Vernovsky, K.3
  • 21
    • 78149467927 scopus 로고    scopus 로고
    • Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas
    • M.J. Dougherty, M. Santi, M.S. Brose, and et al. Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas Neuro-Oncol 12 7 2010 621 630
    • (2010) Neuro-Oncol , vol.12 , Issue.7 , pp. 621-630
    • Dougherty, M.J.1    Santi, M.2    Brose, M.S.3
  • 22
    • 84932649039 scopus 로고    scopus 로고
    • Glioma groups based on TERT promoter mutation, IDH mutation, and 1p/19q codeletion
    • (in press)
    • J.E. Eckel-Passow, D.H. Lachance, A.M. Molinaro, and et al. Glioma groups based on TERT promoter mutation, IDH mutation, and 1p/19q codeletion N. Engl. J. Med 2015 (in press)
    • (2015) N. Engl. J. Med
    • Eckel-Passow, J.E.1    Lachance, D.H.2    Molinaro, A.M.3
  • 23
    • 0033557903 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
    • M. Esteller, S.R. Hamilton, P.C. Burger, S.B. Baylin, and J.G. Herman Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia Cancer Res 59 4 1999 793 797
    • (1999) Cancer Res , vol.59 , Issue.4 , pp. 793-797
    • Esteller, M.1    Hamilton, S.R.2    Burger, P.C.3    Baylin, S.B.4    Herman, J.G.5
  • 24
    • 0034626988 scopus 로고    scopus 로고
    • Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    • M. Esteller, J. Garcia-Foncillas, E. Andion, and et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents N. Engl. J. Med 343 19 2000 1350 1354
    • (2000) N. Engl. J. Med , vol.343 , Issue.19 , pp. 1350-1354
    • Esteller, M.1    Garcia-Foncillas, J.2    Andion, E.3
  • 25
    • 84916936047 scopus 로고    scopus 로고
    • Molecular insights into pediatric brain tumors have the potential to transform therapy
    • A. Gajjar, S.M. Pfister, M.D. Taylor, and R.J. Gilbertson Molecular insights into pediatric brain tumors have the potential to transform therapy Clin. Cancer Res 20 22 2014 5630 5640
    • (2014) Clin. Cancer Res , vol.20 , Issue.22 , pp. 5630-5640
    • Gajjar, A.1    Pfister, S.M.2    Taylor, M.D.3    Gilbertson, R.J.4
  • 26
    • 0035090471 scopus 로고    scopus 로고
    • Oligodendrogliomas: Reproducibility and prognostic value of histologic diagnosis and grading
    • C. Giannini, B.W. Scheithauer, A.L. Weaver, and et al. Oligodendrogliomas: reproducibility and prognostic value of histologic diagnosis and grading J. Neuropathol. Exp. Neurol 60 3 2001 248 262
    • (2001) J. Neuropathol. Exp. Neurol , vol.60 , Issue.3 , pp. 248-262
    • Giannini, C.1    Scheithauer, B.W.2    Weaver, A.L.3
  • 27
    • 69949114447 scopus 로고    scopus 로고
    • Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: A study of 1,010 diffuse gliomas
    • C. Hartmann, J. Meyer, J. Balss, and et al. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas Acta Neuropathol 118 4 2009 469 474
    • (2009) Acta Neuropathol , vol.118 , Issue.4 , pp. 469-474
    • Hartmann, C.1    Meyer, J.2    Balss, J.3
  • 28
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • M.E. Hegi, A.C. Diserens, T. Gorlia, and et al. MGMT gene silencing and benefit from temozolomide in glioblastoma N. Engl. J. Med 352 10 2005 997 1003
    • (2005) N. Engl. J. Med , vol.352 , Issue.10 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 29
    • 84866399483 scopus 로고    scopus 로고
    • Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: Central pathology review of the EORTC-26981/NCIC-CE.3 trial
    • M.E. Hegi, R.C. Janzer, W.L. Lambiv, and et al. Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC-26981/NCIC-CE.3 trial Acta Neuropathol 123 6 2012 841 852
    • (2012) Acta Neuropathol , vol.123 , Issue.6 , pp. 841-852
    • Hegi, M.E.1    Janzer, R.C.2    Lambiv, W.L.3
  • 30
    • 33750563258 scopus 로고    scopus 로고
    • A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma
    • R.B. Jenkins, H. Blair, K.V. Ballman, and et al. A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma Cancer Res 66 20 2006 9852 9861
    • (2006) Cancer Res , vol.66 , Issue.20 , pp. 9852-9861
    • Jenkins, R.B.1    Blair, H.2    Ballman, K.V.3
  • 31
    • 84868625787 scopus 로고    scopus 로고
    • Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
    • Jiao Y., P.J. Killela, Z.J. Reitman, and et al. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas Oncotarget 3 7 2012 709 722
    • (2012) Oncotarget , vol.3 , Issue.7 , pp. 709-722
    • Jiao, Y.1    Killela, P.J.2    Reitman, Z.J.3
  • 32
    • 55349107544 scopus 로고    scopus 로고
    • Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
    • D.T. Jones, S. Kocialkowski, Liu L., and et al. Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas Cancer Res 68 21 2008 8673 8677
    • (2008) Cancer Res , vol.68 , Issue.21 , pp. 8673-8677
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3
  • 33
    • 84876067164 scopus 로고    scopus 로고
    • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
    • P.J. Killela, Z.J. Reitman, Jiao Y., and et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal PNAS 110 15 2013 6021 6026
    • (2013) PNAS , vol.110 , Issue.15 , pp. 6021-6026
    • Killela, P.J.1    Reitman, Z.J.2    Jiao, Y.3
  • 34
    • 0037393981 scopus 로고    scopus 로고
    • Promoter hypermethylation of the DNA repair gene O6-methylguanine-DNA methyltransferase is an independent predictor of shortened progression free survival in patients with low-grade diffuse astrocytomas
    • C. Komine, T. Watanabe, Y. Katayama, A. Yoshino, T. Yokoyama, and T. Fukushima Promoter hypermethylation of the DNA repair gene O6-methylguanine-DNA methyltransferase is an independent predictor of shortened progression free survival in patients with low-grade diffuse astrocytomas Brain Pathol 13 2 2003 176 184
    • (2003) Brain Pathol , vol.13 , Issue.2 , pp. 176-184
    • Komine, C.1    Watanabe, T.2    Katayama, Y.3    Yoshino, A.4    Yokoyama, T.5    Fukushima, T.6
  • 35
    • 68349088073 scopus 로고    scopus 로고
    • Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma
    • A. Korshunov, J. Meyer, D. Capper, and et al. Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma Acta Neuropathol 118 3 2009 401 405
    • (2009) Acta Neuropathol , vol.118 , Issue.3 , pp. 401-405
    • Korshunov, A.1    Meyer, J.2    Capper, D.3
  • 36
    • 84891848472 scopus 로고    scopus 로고
    • Primary glioblastoma with oligodendroglial differentiation has better clinical outcome but no difference in common biological markers compared with other types of glioblastoma
    • R.C. Laxton, S. Popov, L. Doey, and et al. Primary glioblastoma with oligodendroglial differentiation has better clinical outcome but no difference in common biological markers compared with other types of glioblastoma Neuro-Oncol 15 12 2013 1635 1643
    • (2013) Neuro-Oncol , vol.15 , Issue.12 , pp. 1635-1643
    • Laxton, R.C.1    Popov, S.2    Doey, L.3
  • 37
    • 84876283937 scopus 로고    scopus 로고
    • IDH1 mutations in oligodendroglial tumors: Comparative analysis of direct sequencing, pyrosequencing, immunohistochemistry, nested PCR and PNA-mediated clamping PCR
    • D. Lee, Y.L. Suh, Kang S.Y., T.I. Park, J.Y. Jeong, and S.H. Kim IDH1 mutations in oligodendroglial tumors: comparative analysis of direct sequencing, pyrosequencing, immunohistochemistry, nested PCR and PNA-mediated clamping PCR Brain Pathol 23 3 2013 285 293
    • (2013) Brain Pathol , vol.23 , Issue.3 , pp. 285-293
    • Lee, D.1    Suh, Y.L.2    Kang, S.Y.3    Park, T.I.4    Jeong, J.Y.5    Kim, S.H.6
  • 38
    • 84877785024 scopus 로고    scopus 로고
    • Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
    • P.W. Lewis, M.M. Muller, M.S. Koletsky, and et al. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma Science 340 6134 2013 857 861
    • (2013) Science , vol.340 , Issue.6134 , pp. 857-861
    • Lewis, P.W.1    Muller, M.M.2    Koletsky, M.S.3
  • 39
    • 84871020024 scopus 로고    scopus 로고
    • Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations
    • Liu X.Y., N. Gerges, A. Korshunov, and et al. Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations Acta Neuropathol 124 5 2012 615 625
    • (2012) Acta Neuropathol , vol.124 , Issue.5 , pp. 615-625
    • Liu, X.Y.1    Gerges, N.2    Korshunov, A.3
  • 41
    • 85027948565 scopus 로고    scopus 로고
    • International Society of Neuropathology-Haarlem consensus guidelines for nervous system tumor classification and grading
    • D.N. Louis, A. Perry, P. Burger, and et al. International Society Of Neuropathology-Haarlem consensus guidelines for nervous system tumor classification and grading Brain Pathol 24 5 2014 429 435
    • (2014) Brain Pathol , vol.24 , Issue.5 , pp. 429-435
    • Louis, D.N.1    Perry, A.2    Burger, P.3
  • 42
    • 84861789249 scopus 로고    scopus 로고
    • Comparison of immunohistochemistry, DNA sequencing and allele-specific PCR for the detection of IDH1 mutations in gliomas
    • D. Loussouarn, A.G. Le Loupp, J.S. Frenel, and et al. Comparison of immunohistochemistry, DNA sequencing and allele-specific PCR for the detection of IDH1 mutations in gliomas Int. J. Oncol 40 6 2012 2058 2062
    • (2012) Int. J. Oncol , vol.40 , Issue.6 , pp. 2058-2062
    • Loussouarn, D.1    Le Loupp, A.G.2    Frenel, J.S.3
  • 43
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutation impairs histone demethylation and results in a block to cell differentiation
    • Lu C., P.S. Ward, G.S. Kapoor, and et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation Nature 483 7390 2012 474 478
    • (2012) Nature , vol.483 , Issue.7390 , pp. 474-478
    • Lu, C.1    Ward, P.S.2    Kapoor, G.S.3
  • 44
    • 33750464471 scopus 로고    scopus 로고
    • Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma
    • J.A. Maxwell, S.P. Johnson, J.A. Quinn, and et al. Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma Mol. Cancer Ther 5 10 2006 2531 2539
    • (2006) Mol. Cancer Ther , vol.5 , Issue.10 , pp. 2531-2539
    • Maxwell, J.A.1    Johnson, S.P.2    Quinn, J.A.3
  • 45
    • 82955165744 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors
    • M. Mellai, A. Piazzi, V. Caldera, and et al. IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors J. Neurooncol 105 2 2011 345 357
    • (2011) J. Neurooncol , vol.105 , Issue.2 , pp. 345-357
    • Mellai, M.1    Piazzi, A.2    Caldera, V.3
  • 46
    • 84864367362 scopus 로고    scopus 로고
    • MGMT promoter hypermethylation and its associations with genetic alterations in a series of 350 brain tumors
    • M. Mellai, O. Monzeglio, A. Piazzi, and et al. MGMT promoter hypermethylation and its associations with genetic alterations in a series of 350 brain tumors J. Neurooncol 107 3 2012 617 631
    • (2012) J. Neurooncol , vol.107 , Issue.3 , pp. 617-631
    • Mellai, M.1    Monzeglio, O.2    Piazzi, A.3
  • 47
    • 78651067051 scopus 로고    scopus 로고
    • Absence of IDH mutation identifies a novel radiologic and molecular subtype of WHO grade II gliomas with dismal prognosis
    • P. Metellus, B. Coulibaly, C. Colin, and et al. Absence of IDH mutation identifies a novel radiologic and molecular subtype of WHO grade II gliomas with dismal prognosis Acta Neuropathol 120 6 2010 719 729
    • (2010) Acta Neuropathol , vol.120 , Issue.6 , pp. 719-729
    • Metellus, P.1    Coulibaly, B.2    Colin, C.3
  • 48
    • 0034795045 scopus 로고    scopus 로고
    • Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C → A:T mutations of the TP53 tumor suppressor gene
    • M. Nakamura, T. Watanabe, Y. Yonekawa, P. Kleihues, and H. Ohgaki Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C → A:T mutations of the TP53 tumor suppressor gene Carcinogenesis 22 10 2001 1715 1719
    • (2001) Carcinogenesis , vol.22 , Issue.10 , pp. 1715-1719
    • Nakamura, M.1    Watanabe, T.2    Yonekawa, Y.3    Kleihues, P.4    Ohgaki, H.5
  • 49
    • 77952108366 scopus 로고    scopus 로고
    • Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    • H. Noushmehr, D.J. Weisenberger, K. Diefes, and et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma Cancer Cell 17 5 2010 510 522
    • (2010) Cancer Cell , vol.17 , Issue.5 , pp. 510-522
    • Noushmehr, H.1    Weisenberger, D.J.2    Diefes, K.3
  • 50
    • 80052713548 scopus 로고    scopus 로고
    • Genetic profile of astrocytic and oligodendroglial gliomas
    • H. Ohgaki, and P. Kleihues Genetic profile of astrocytic and oligodendroglial gliomas Brain Tumor Pathol 28 3 2011 177 183
    • (2011) Brain Tumor Pathol , vol.28 , Issue.3 , pp. 177-183
    • Ohgaki, H.1    Kleihues, P.2
  • 51
    • 84874091180 scopus 로고    scopus 로고
    • The definition of primary and secondary glioblastoma
    • H. Ohgaki, and P. Kleihues The definition of primary and secondary glioblastoma Clin. Cancer Res 19 4 2013 764 772
    • (2013) Clin. Cancer Res , vol.19 , Issue.4 , pp. 764-772
    • Ohgaki, H.1    Kleihues, P.2
  • 52
    • 3242722352 scopus 로고    scopus 로고
    • Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas
    • Y. Okamoto, P.L. Di Patre, C. Burkhard, and et al. Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas Acta Neuropathol 108 1 2004 49 56
    • (2004) Acta Neuropathol , vol.108 , Issue.1 , pp. 49-56
    • Okamoto, Y.1    Di Patre, P.L.2    Burkhard, C.3
  • 53
    • 84939979467 scopus 로고    scopus 로고
    • IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II-III diffuse gliomas
    • A. Olar, K.M. Wani, K.D. Alfaro-Munoz, and et al. IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II-III diffuse gliomas Acta Neuropathol 129 4 2015 585 596
    • (2015) Acta Neuropathol , vol.129 , Issue.4 , pp. 585-596
    • Olar, A.1    Wani, K.M.2    Alfaro-Munoz, K.D.3
  • 54
    • 84886009591 scopus 로고    scopus 로고
    • CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010
    • Q.T. Ostrom, H. Gittleman, P. Farah, and et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2006-2010 Neuro-Oncol 15 Suppl. 2 2013 ii1 ii56
    • (2013) Neuro-Oncol , vol.15 , pp. ii1-ii56
    • Ostrom, Q.T.1    Gittleman, H.2    Farah, P.3
  • 55
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • D.W. Parsons, S. Jones, Zhang X., and et al. An integrated genomic analysis of human glioblastoma multiforme Science 321 5897 2008 1807 1812
    • (2008) Science , vol.321 , Issue.5897 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 57
    • 84882247189 scopus 로고    scopus 로고
    • PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma
    • J.J. Phillips, D. Aranda, D.W. Ellison, and et al. PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma Brain Pathol 23 5 2013 565 573
    • (2013) Brain Pathol , vol.23 , Issue.5 , pp. 565-573
    • Phillips, J.J.1    Aranda, D.2    Ellison, D.W.3
  • 58
    • 78951489314 scopus 로고    scopus 로고
    • IDH1 mutations are common in malignant gliomas arising in adolescents: A report from the Children's Oncology Group
    • I.F. Pollack, R.L. Hamilton, R.W. Sobol, and et al. IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group Childs Nerv. Syst 27 1 2011 87 94
    • (2011) Childs Nerv. Syst , vol.27 , Issue.1 , pp. 87-94
    • Pollack, I.F.1    Hamilton, R.L.2    Sobol, R.W.3
  • 59
    • 51249098488 scopus 로고    scopus 로고
    • Anti-O6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: Observer variability and lack of association with patient survival impede its use as clinical biomarker
    • M. Preusser, R. Charles Janzer, J. Felsberg, and et al. Anti-O6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: observer variability and lack of association with patient survival impede its use as clinical biomarker Brain Pathol 18 4 2008 520 532
    • (2008) Brain Pathol , vol.18 , Issue.4 , pp. 520-532
    • Preusser, M.1    Charles Janzer, R.2    Felsberg, J.3
  • 60
    • 84929712325 scopus 로고    scopus 로고
    • ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma
    • D.E. Reuss, F. Sahm, D. Schrimpf, and et al. ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma Acta Neuropathol 129 1 2015 133 146
    • (2015) Acta Neuropathol , vol.129 , Issue.1 , pp. 133-146
    • Reuss, D.E.1    Sahm, F.2    Schrimpf, D.3
  • 61
    • 84899457632 scopus 로고    scopus 로고
    • Contrast enhancement in 1p/19q-codeleted anaplastic oligodendrogliomas is associated with 9p loss, genomic instability, and angiogenic gene expression
    • G. Reyes-Botero, C. Dehais, A. Idbaih, and et al. Contrast enhancement in 1p/19q-codeleted anaplastic oligodendrogliomas is associated with 9p loss, genomic instability, and angiogenic gene expression Neuro-Oncol 16 5 2014 662 670
    • (2014) Neuro-Oncol , vol.16 , Issue.5 , pp. 662-670
    • Reyes-Botero, G.1    Dehais, C.2    Idbaih, A.3
  • 62
    • 37549037792 scopus 로고    scopus 로고
    • MGMT immunohistochemical expression and promoter methylation in human glioblastoma
    • F.J. Rodriguez, S.N. Thibodeau, R.B. Jenkins, and et al. MGMT immunohistochemical expression and promoter methylation in human glioblastoma Appl. Immunohistochem. Mol. Morphol 16 1 2008 59 65
    • (2008) Appl. Immunohistochem. Mol. Morphol , vol.16 , Issue.1 , pp. 59-65
    • Rodriguez, F.J.1    Thibodeau, S.N.2    Jenkins, R.B.3
  • 63
    • 84875893063 scopus 로고    scopus 로고
    • Pathological and molecular advances in pediatric low-grade astrocytoma
    • F.J. Rodriguez, K.S. Lim, D. Bowers, and C.G. Eberhart Pathological and molecular advances in pediatric low-grade astrocytoma Annu. Rev. Pathol 8 2013 361 379
    • (2013) Annu. Rev. Pathol , vol.8 , pp. 361-379
    • Rodriguez, F.J.1    Lim, K.S.2    Bowers, D.3    Eberhart, C.G.4
  • 64
    • 84904563334 scopus 로고    scopus 로고
    • Clinicopathologic features of pediatric oligodendrogliomas: A series of 50 patients
    • F.J. Rodriguez, T. Tihan, Lin D., and et al. Clinicopathologic features of pediatric oligodendrogliomas: a series of 50 patients Am. J. Surg. Pathol 38 8 2014 1058 1070
    • (2014) Am. J. Surg. Pathol , vol.38 , Issue.8 , pp. 1058-1070
    • Rodriguez, F.J.1    Tihan, T.2    Lin, D.3
  • 65
    • 84866411339 scopus 로고    scopus 로고
    • CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas
    • F. Sahm, C. Koelsche, J. Meyer, and et al. CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas Acta Neuropathol 123 6 2012 853 860
    • (2012) Acta Neuropathol , vol.123 , Issue.6 , pp. 853-860
    • Sahm, F.1    Koelsche, C.2    Meyer, J.3
  • 66
    • 84919921568 scopus 로고    scopus 로고
    • Farewell to oligoastrocytoma: In situ molecular genetics favor classification as either oligodendroglioma or astrocytoma
    • F. Sahm, D. Reuss, C. Koelsche, and et al. Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma Acta Neuropathol 128 4 2014 551 559
    • (2014) Acta Neuropathol , vol.128 , Issue.4 , pp. 551-559
    • Sahm, F.1    Reuss, D.2    Koelsche, C.3
  • 67
    • 79954441895 scopus 로고    scopus 로고
    • Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
    • G. Schindler, D. Capper, J. Meyer, and et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma Acta Neuropathol 121 3 2011 397 405
    • (2011) Acta Neuropathol , vol.121 , Issue.3 , pp. 397-405
    • Schindler, G.1    Capper, D.2    Meyer, J.3
  • 68
    • 84862777348 scopus 로고    scopus 로고
    • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
    • J. Schwartzentruber, A. Korshunov, Liu X.Y., and et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma Nature 482 7384 2012 226 231
    • (2012) Nature , vol.482 , Issue.7384 , pp. 226-231
    • Schwartzentruber, J.1    Korshunov, A.2    Liu, X.Y.3
  • 69
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • R. Stupp, W.P. Mason, M.J. van den Bent, and et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma N. Engl. J. Med 352 10 2005 987 996
    • (2005) N. Engl. J. Med , vol.352 , Issue.10 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 70
    • 84867606428 scopus 로고    scopus 로고
    • Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
    • D. Sturm, H. Witt, V. Hovestadt, and et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma Cancer Cell 22 4 2012 425 437
    • (2012) Cancer Cell , vol.22 , Issue.4 , pp. 425-437
    • Sturm, D.1    Witt, H.2    Hovestadt, V.3
  • 71
    • 84894573670 scopus 로고    scopus 로고
    • Paediatric and adult glioblastoma: Multiform (epi)genomic culprits emerge
    • D. Sturm, S. Bender, D.T. Jones, and et al. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge Nat. Rev. Cancer 14 2 2014 92 107
    • (2014) Nat. Rev. Cancer , vol.14 , Issue.2 , pp. 92-107
    • Sturm, D.1    Bender, S.2    Jones, D.T.3
  • 72
    • 80052780994 scopus 로고    scopus 로고
    • Detection of IDH1 mutation in human gliomas: Comparison of immunohistochemistry and sequencing
    • S. Takano, Tian W., M. Matsuda, and et al. Detection of IDH1 mutation in human gliomas: comparison of immunohistochemistry and sequencing Brain Tumor Pathol 28 2 2011 115 123
    • (2011) Brain Tumor Pathol , vol.28 , Issue.2 , pp. 115-123
    • Takano, S.1    Tian, W.2    Matsuda, M.3
  • 73
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • The Cancer Genome Atlas Network
    • The Cancer Genome Atlas Network Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature 455 7216 2008 1061 1068
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
  • 74
    • 84932628860 scopus 로고    scopus 로고
    • Comprehensive, integrative genomic analysis of diffuse lower grade gliomas
    • The Cancer Genome Atlas Research Network (in press)
    • The Cancer Genome Atlas Research Network Comprehensive, integrative genomic analysis of diffuse lower grade gliomas N. Engl. J. Med 2015 (in press)
    • (2015) N. Engl. J. Med
  • 75
    • 84871336632 scopus 로고    scopus 로고
    • Moving toward molecular classification of diffuse gliomas in adults
    • B.J. Theeler, W.K. Yung, G.N. Fuller, and J.F. De Groot Moving toward molecular classification of diffuse gliomas in adults Neurology 79 18 2012 1917 1926
    • (2012) Neurology , vol.79 , Issue.18 , pp. 1917-1926
    • Theeler, B.J.1    Yung, W.K.2    Fuller, G.N.3    De Groot, J.F.4
  • 77
    • 0028175707 scopus 로고
    • P53 mutation, expression, and DNA ploidy in evolving gliomas: Evidence for two pathways of progression
    • D.J. van Meyel, D.A. Ramsay, A.G. Casson, M. Keeney, A.F. Chambers, and J.G. Cairncross p53 mutation, expression, and DNA ploidy in evolving gliomas: evidence for two pathways of progression J. Natl Cancer Inst 86 13 1994 1011 1017
    • (1994) J. Natl Cancer Inst , vol.86 , Issue.13 , pp. 1011-1017
    • Van Meyel, D.J.1    Ramsay, D.A.2    Casson, A.G.3    Keeney, M.4    Chambers, A.F.5    Cairncross, J.G.6
  • 78
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • R.G. Verhaak, K.A. Hoadley, E. Purdom, and et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 Cancer Cell 17 1 2010 98 110
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3
  • 79
    • 84901755190 scopus 로고    scopus 로고
    • Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas
    • H. Wakimoto, S. Tanaka, W.T. Curry, and et al. Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas Clin. Cancer Res 20 11 2014 2898 2909
    • (2014) Clin. Cancer Res , vol.20 , Issue.11 , pp. 2898-2909
    • Wakimoto, H.1    Tanaka, S.2    Curry, W.T.3
  • 80
    • 0030917734 scopus 로고    scopus 로고
    • Incidence and timing of p53 mutations during astrocytoma progression in patients with multiple biopsies
    • K. Watanabe, K. Sato, W. Biernat, and et al. Incidence and timing of p53 mutations during astrocytoma progression in patients with multiple biopsies Clin. Cancer Res 3 4 1997 523 530
    • (1997) Clin. Cancer Res , vol.3 , Issue.4 , pp. 523-530
    • Watanabe, K.1    Sato, K.2    Biernat, W.3
  • 81
    • 65349150503 scopus 로고    scopus 로고
    • IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
    • T. Watanabe, S. Nobusawa, P. Kleihues, and H. Ohgaki IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas Am. J. Pathol 174 4 2009 1149 1153
    • (2009) Am. J. Pathol , vol.174 , Issue.4 , pp. 1149-1153
    • Watanabe, T.1    Nobusawa, S.2    Kleihues, P.3    Ohgaki, H.4
  • 82
    • 84929999099 scopus 로고    scopus 로고
    • Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma
    • B. Wiestler, D. Capper, M. Sill, and et al. Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma Acta Neuropathol 128 4 2014 561 571
    • (2014) Acta Neuropathol , vol.128 , Issue.4 , pp. 561-571
    • Wiestler, B.1    Capper, D.2    Sill, M.3
  • 83
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
    • Xu W., Yang H., Liu Y., and et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases Cancer Cell 19 1 2011 17 30
    • (2011) Cancer Cell , vol.19 , Issue.1 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3
  • 84
    • 4043105583 scopus 로고    scopus 로고
    • Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity
    • Xu X., Zhao J., Xu Z., and et al. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity J. Biol. Chem 279 32 2004 33946 33957
    • (2004) J. Biol. Chem , vol.279 , Issue.32 , pp. 33946-33957
    • Xu, X.1    Zhao, J.2    Xu, Z.3
  • 85
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan H., D.W. Parsons, Jin G., and et al. IDH1 and IDH2 mutations in gliomas N. Engl. J. Med 360 8 2009 765 773
    • (2009) N. Engl. J. Med , vol.360 , Issue.8 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 86
    • 82755194965 scopus 로고    scopus 로고
    • Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers
    • S. Yip, Y.S. Butterfield, O. Morozova, and et al. Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers J. Pathol 226 1 2012 7 16
    • (2012) J. Pathol , vol.226 , Issue.1 , pp. 7-16
    • Yip, S.1    Butterfield, Y.S.2    Morozova, O.3
  • 87
    • 84878723078 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
    • Zhang J., Wu G., C.P. Miller, and et al. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas Nat. Genet 45 6 2013 602 612
    • (2013) Nat. Genet , vol.45 , Issue.6 , pp. 602-612
    • Zhang, J.1    Wu, G.2    Miller, C.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.