ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

Acta Neuropathologica

Volumn 129, Issue 1, 2015, Pages 133-146

  Reuss, David E ^a,b   Sahm, Felix ^a,b   Schrimpf, Daniel ^a,b   Wiestler, Benedikt ^a,c   Capper, David ^a,b   Koelsche, Christian ^a,b   Schweizer, Leonille ^a,b   Korshunov, Andrey ^a,b   Jones, David T W ^a   Hovestadt, Volker ^a   Mittelbronn, Michel ^a,d   Schittenhelm, Jens ^e   Herold Mende, Christel ^b   Unterberg, Andreas ^b   Platten, Michael ^a,c   Weller, Michael ^f   Wick, Wolfgang ^a,c   Pfister, Stefan M ^a,c   von Deimling, Andreas ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d GOETHE UNIVERSITY   (Germany)

^e UNIVERSITY OF TÜBINGEN   (Germany)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

1p 19q; 7p 10q; Astrocytoma; ATRX; Diffuse glioma; Glioblastoma; H3F3A; IDH; Oligodendroglioma

Indexed keywords

ATRX PROTEIN, HUMAN; DNA HELICASE; IDH1 PROTEIN, HUMAN; ISOCITRATE DEHYDROGENASE; NUCLEAR PROTEIN;

ADOLESCENT; ADULT; AGED; ALGORITHM; ASTROCYTOMA; BRAIN NEOPLASMS; COPY NUMBER VARIATION; FEMALE; GENETICS; GLIOBLASTOMA; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MIDDLE AGED; MUTATION; OLIGODENDROGLIOMA; PATHOLOGY; PROCEDURES; PROGNOSIS; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALGORITHMS; ASTROCYTOMA; BRAIN NEOPLASMS; DNA COPY NUMBER VARIATIONS; DNA HELICASES; FEMALE; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; ISOCITRATE DEHYDROGENASE; MALE; MIDDLE AGED; MUTATION; NUCLEAR PROTEINS; OLIGODENDROGLIOMA; PROGNOSIS; YOUNG ADULT;

EID: 84929712325     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-014-1370-3     Document Type: Article

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