CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas

Acta Neuropathologica

Volumn 123, Issue 6, 2012, Pages 853-860

  Sahm, Felix ^a,b   Koelsche, Christian ^a   Meyer, Jochen ^b   Pusch, Stefan ^b   Lindenberg, Kerstin ^b   Mueller, Wolf ^a   Herold Mende, Christel ^a   Von Deimling, Andreas ^a   Hartmann, Christian ^a,c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

19q; 1p; CIC; FUBP1; Oligoastrocytoma; Oligodendroglioma

Indexed keywords

DNA;

ADULT; ARTICLE; ASTROCYTOMA; BINDING SITE; BRAIN TUMOR; CIC GENE; DNA BINDING; EXON; FEMALE; FUBP1 GENE; GENE; GENE MUTATION; GENETIC CODE; HUMAN; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MEDULLOBLASTOMA; MICROSATELLITE MARKER; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIOMA; PRIMARY TUMOR; PRIORITY JOURNAL;

ADULT; ASTROCYTOMA; BRAIN NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 1; DNA HELICASES; DNA-BINDING PROTEINS; EXONS; FEMALE; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; MUTATION; NEOPLASM GRADING; OLIGODENDROGLIOMA; REPRESSOR PROTEINS;

EID: 84866411339     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-012-0993-5     Document Type: Article

References (14)

1. Balss J, Meyer J, Mueller W et al (2008) Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol 116:597-602
2. Bender B, Wiestler OD, von Deimling A (1994) A device for processing large acrylamide gels. Biotechniques 16:204-206
3. Bettegowda C, Agrawal N, Jiao Y et al (2011) Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science 333:1453-1455
4. Duncan R, Bazar L, Michelotti G et al (1994) A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif. Genes Dev 8:465-480
5. Hartmann C, Meyer J, Balss J et al (2009) Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1010 diffuse gliomas. Acta Neuropathol 118:469-474
6. Kim Y, Andreu MJ, Lim B et al (2011) Gene regulation by MAPK substrate competition. Dev Cell 20:880-887
7. Lee CJ, Chan WI, Cheung M et al (2002) CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons. Brain Res Mol Brain Res 106:151-156
8. Lee CJ, Chan WI, Scotting PJ (2005) CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas. J Neurooncol 73:101-108
9. Louis D, Ohgaki H, Wiestler O et al (2007) World Health Organization Classification of Tumours of the Central Nervous System. In: Bosman F, Jaffe E, Lakhani S et al (eds) World Health Organization Classification of Tumours, 4th edn. IARC, Lyon
10. Malz M, Weber A, Singer S et al (2009) Overexpression of far upstream element binding proteins: a mechanism regulating proliferation and migration in liver cancer cells. Hepatology 50:1130-1139
11. Parsons DW, Li M, Zhang X et al (2011) The genetic landscape of the childhood cancer medulloblastoma. Science 331:435-439
12. Rabenhorst U, Beinoraviciute-Kellner R, Brezniceanu ML et al (2009) Overexpression of the far upstream element binding protein 1 in hepatocellular carcinoma is required for tumor growth. Hepatology 50:1121-1129
13. Weller M, Berger H, Hartmann C et al (2007) Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker? Clin Cancer Res 13:6933-6937
14. Yip S, Butterfield YS, Morozova O et al (2012) Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. J Pathol 226:7-16