Anti-O6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: Observer variability and lack of association with patient survival impede its use as clinical biomarker

Brain Pathology

Volumn 18, Issue 4, 2008, Pages 520-532

  Preusser, Matthias ^b   Charles Janzer, Robert ^c   Felsberg, Jörg ^e   Reifenberger, Guido ^e   Hamou, Marie France ^d   Diserens, Annie Claire ^d   Stupp, Roger ^c   Gorlia, Thierry ^f   Marosi, Christine ^b   Heinzl, Harald ^b   Hainfellner, Johannes A ^a   Hegi, Monika ^d  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e HEINRICH HEINE UNIVERSITY   (Germany)

^f EORTC DATA CENTER   (Belgium)

Author keywords

Biomarker; Glioblastoma; Immunohistochemistry; MGMT; Prognosis

Indexed keywords

ANTIBODY; BIOLOGICAL MARKER; EPITOPE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TEMOZOLOMIDE;

ADULT; AGED; ARTICLE; BRAIN TUMOR; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL LABORATORY; DNA METHYLATION; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; NEUROPATHOLOGY; OUTCOME ASSESSMENT; PROGNOSIS; PROMOTER REGION; PROTEIN EXPRESSION; TISSUE MICROARRAY; TREATMENT OUTCOME; TUMOR DIAGNOSIS;

ADULT; AGED; ANTIBODIES; ANTIBODY SPECIFICITY; BRAIN NEOPLASMS; COHORT STUDIES; DIAGNOSIS, DIFFERENTIAL; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; OBSERVER VARIATION; PREDICTIVE VALUE OF TESTS; PROMOTER REGIONS, GENETIC; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 51249098488     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2008.00153.x     Document Type: Article

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