Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 17, 2015, Pages 5511-5526

  Kamal, Ahmed ^a,b   Sathish, Manda ^a   Nayak, V Lakshma ^a   Srinivasulu, Vunnam ^a   Kavitha, Botla ^b   Tangella, Yellaiah ^a   Thummuri, Dinesh ^b   Bagul, Chandrakant ^a,b   Shankaraiah, Nagula ^b   Nagesh, Narayana ^c  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^c CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Anticancer activity; Dithiocarbamate; DNA binding affinity; Pharmacophore; Topoisomerase II; Carboline

Indexed keywords

ALLYL [[1 (4 FLUOROPHENYL) 9 METHYL 9H PYRIDO[3,4 B] INDOL 3 YL]METHYL]CARBAMODITHIOATE; ALLYL [[1 (4 FLUOROPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL] METHYL]CARBAMODITHIOATE; ALLYL [[1 (4 METHOXYPHENYL) 9 METHYL 9H PYRIDO[3,4 B]INDOL 3 YL]METHYL]CARBAMODITHIOATE; ALLYL [[9 METHYL 1 [4 (TRIFLUOROMETHYL)PHENYL] 9H PYRIDO[3,4 B]INDOL 3 YL]METHYL]CARBAMODITHIOATE; ANTINEOPLASTIC AGENT; BENZYL [[1 (4 FLUOROPHENYL) 9 METHYL 9H PYRIDO[3,4 B] INDOL 3 YL]METHYL]CARBAMODITHIOATE; BENZYL [[1 (4 FLUOROPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL] METHYL]CARBAMODITHIOATE; BENZYL [[1 (4 METHOXYPHENYL) 9 METHYL 9H PYRIDO[3B]INDOL 3 YL]METHYL]CARBAMODITHIOATE; BENZYL [[1 [4 (TRIFLUOROMETHYL)PHENYL] 9H PYRIDO[3,4 B]INDOL 3 YL]METHYL]CARBAMODITHIOATE; BENZYL [[9 METHYL 1 [4 (TRIFLUOROMETHYL)PHENYL] 9H PYRIDO[3,4 B]INDOL 3 YL]METHYL]CARBAMODITHIOATE; BETA CARBOLINE DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); METHYL [(9 METHYL 1 (3,4,5 TRIMETHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL)METHYL]CARBAMODITHIOATE; METHYL [[1 (3,4,5 TRIMETHOXYPHENYL) 9H PYRIDO[3,4 B] INDOL 3 YL]METHYL]CARBAMODITHIOATE; METHYL [[1 (4 FLUOROPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]METHYL]CARBAMODITHIOATE; METHYL [[1 (4 METHOXYPHENYL) 9 METHYL 9H PYRIDO[3,4 B]INDOL 3 YL]METHYL]CARBAMODITHIOATE; METHYL [[1 (4 METHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]METHYL]CARBAMODITHIOATE; METHYL [[1 (FLUOROPHENYL) 9 METHYL 9H PYRIDO[3,4 B] INDOL 3 YL]METHYL] CARBAMODITHIOATE; METHYL [[9 METHYL 1 [4 (TRIFLUOROMETHYL)PHENYL] 9H PYRIDO[3,4 B]INDOL 3 YL]METHYL]CARBAMODITHIOATE; UNCLASSIFIED DRUG; [1 (3,4,5 TRIMETHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]METHANAMINE; [1 (4 FLUOROPHENYL) 9 METHYL 9H PYRIDO[3,4 B]INDOL 3 YL]METHANAMINE; [1 (4 FLUOROPHENYL) 9H PYRIDO[3,4-B]INDOL 3 YL]METHANAMINE; [1 (4 METHOXYPHENYL) 9 METHYL 9H PYRIDO[3,4 B]INDOL 3 YL]METHANAMINE; [1 (4 METHOXYPHENYL) 9H PYRIDO[3,4 B]INDOL 3 YL]METHANAMINE; [1 [4 (TRIFLUOROMETHYL)PHENYL] 9H PYRIDO[3,4 B]INDOL 3 YL]METHANAMINE; [9 METHHYL 1 [4 (TRIFLUOROMETHYL)PHENYL] 9H PYRIDO[3,4 B] INDOL 3 YL]METHANAMINE; [9 METHHYL 1 [4 (TRIFLUOROMETHYL)PHENYL] 9H PYRIDO[3,4 B]INDOL 3 YL]METHANAMINE; [9 METHYL 1 (3,4,5 TRIMETHOXYPHENYL) 9H PYRIDO[3,4 B] INDOL 3 YL]METHANAMINE; CARBOLINE DERIVATIVE; DNA; GYRASE INHIBITOR;

APOPTOSIS; ARTICLE; CANCER CELL LINE; CELL CYCLE REGULATION; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG DESIGN; DRUG MECHANISM; DRUG POTENTIATION; DRUG SYNTHESIS; ENZYME INHIBITION ASSAY; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; IC50; MOLECULAR DOCKING; ULTRAVIOLET SPECTROSCOPY; CHEMICAL STRUCTURE; CHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBOLINES; DNA; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

EID: 84946490196     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.07.037     Document Type: Article

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