Synthesis and cytotoxic activities of β-carboline amino acid ester conjugates

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 20, 2006, Pages 6998-7010

  Zhao, Ming ^a,b   Bi, Lanrong ^a,b   Wang, Wei ^a,b   Wang, Chao ^a,b   Baudy Floc'h, Michèle ^b,d   Ju, Jingfang ^b,c   Peng, Shiqi ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c UNIVERSITY OF SOUTH ALABAMA   (United States)

^d UNIVERSITÉ DE RENNES 1   (France)

Author keywords

Anti cancer; Beta carboline; Cytotoxicity

Indexed keywords

ARGININE; CARBOLINE DERIVATIVE; CYTOTOXIC AGENT; N (1 METHYL BETA CARBOLINE 3 CARBONYL)ALANINE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)ARGININE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)ASPARTIC ACID LEUCINE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)GLUTAMIC ACID LEUCINE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)GLYCINE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)ISOLEUCINE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)LEUCINE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)LYSINE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)PHENYLALANINE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)PROLINE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)SERINE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)THREONINE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)TYROSINE BENZYL ESTER; N (1 METHYL BETA CARBOLINE 3 CARBONYL)VALINE BENZYL ESTER; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MEMBRANE PERMEABILITY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; UTERINE CERVIX CARCINOMA;

AMINO ACIDS; ANTINEOPLASTIC AGENTS; BINDING SITES; CARBOLINES; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; DNA; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ESTERS; HELA CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 33748124815     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.06.021     Document Type: Article

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