Novel antitumor indolizino[6,7-b]indoles with multiple modes of action: DNA cross-linking and topoisomerase i and II inhibition

Journal of Medicinal Chemistry

Volumn 56, Issue 4, 2013, Pages 1544-1563

  Chaniyara, Ravi ^a,d   Tala, Satishkumar ^a   Chen, Chi Wei ^a,c   Zang, Xiuguo ^b   Kakadiya, Rajesh ^a   Lin, Li Fang ^a   Chen, Ching Huang ^a   Chien, Shin I ^c   Chou, Ting Chao ^b   Tsai, Tung Hu ^c   Lee, Te Chang ^a   Shah, Anamik ^d   Su, Tsann Long ^a,e  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d SAURASHTRA UNIVERSITY   (India)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; IRINOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; [3 (3 CHLORO 4 FLUOROPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]DIMETHANOL; [3 (3 CHLORO 4 FLUOROPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INSOLE 1,2 DIYL]BIS(METHYLENE)BIS(ETHYLCARBAMATE); [3 (3,4 DIFLUOROPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]BIS(METHYLENE)BIS(ETHYLCARBAMATE); [3 (3,4 DIFLUOROPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]DIMETHANOL; [3 (3,4 DIMETHOXYPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]BIS(METHYLENE)BIS(ETHYLCARBAMATE); [3 (3,4 DIMETHOXYPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]DIMETHANOL; [3 (3,4,5 TRIMETHOXYPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]DIMETHANOL; [3 (4 CHLOROPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]BIS(METHYLENE)BIS(ETHYLCARBAMATE); [3 (4 CHLOROPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]DIMETHANOL; [3 (4 FLUOROPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]BIS(METHYLENE)BIS(ETHYLCARBAMATE); [3 (4 FLUOROPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO[6,7 B]INDOLE 1,2 DIYL]DIMETHANOL; [3 (4 METHOXYPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]BIS(METHYLENE)BIS(ETHYLCARBAMATE); [3 (4 METHOXYPHENYL) 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]DIMETHANOL; [3 ETHYL 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]BIS(METHYLENE)BIS(ETHYLCARBAMATE); [3 ETHYL 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]DIMETHANOL; [3 PHENYL 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO[6,7 B]INDOLE 1,2 DIYL]BIS(METHYLENE)BIS(ETHYLCARBAMATE); [3 PHENYL 6 METHYL 6,11 DIHYDRO 5H INDOLIZINO[6,7 B]INDOLE 1,2 DIYL]DIMETHANOL; [3,6 DIMETHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]BIS(METHYLENE)BIS(ETHYLCARBAMATE); [3,6 DIMETHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]BIS(METHYLENE)BIS(ISOPROPYLCARBAMATE); [3,6 DIMETHYL 6,11 DIHYDRO 5H INDOLIZINO[6,7 B]INDOLE 1,2 DIYL]DIMETHANOL; [6 BENZYL 3 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]BIS(METHYLENE)BIS(ETHYLCARBAMATE); [6 BENZYL 3 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]DIMETHANOL; [6 BENZYL 3 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE DIYL]BIS(METHYLENE)BIS(ISOPROPYLCARBAMATE); [6 ETHYL 3 ETHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]BIS(METHYLENE)BIS(ISOPROPYLCARBAMATE); [6 ETHYL 3 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]BIS(METHYLENE)BIS(ETHYLCARBAMATE); [6 ETHYL 3 METHYL 6,11 DIHYDRO 5H INDOLIZINO [6,7 B]INDOLE 1,2 DIYL]DIMETHANOL;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CELL CYCLE ARREST; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DNA CROSS LINKING; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ADENOCARCINOMA; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR CELL; TUMOR REGRESSION; TUMOR XENOGRAFT;

EID: 84874631478     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301788a     Document Type: Article

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