The synthesis of amino-acid functionalized β-carbolines as topoisomerase II inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 10, 2001, Pages 1251-1255

  Deveau, Amy Morin ^a   Labroli, Marc A ^a   Dieckhaus, Christine M ^a   Barthen, Mary T ^a   Smith, Kirsten S ^a   MacDonald, Timothy L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; AZATOXIN; BETA CARBOLINE DERIVATIVE; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ETOPOSIDE; PIPERAZINEDIONE; TRYPOSTATIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL LINE; DRUG ACTIVITY; DRUG DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; PROSTATE CARCINOMA; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; ANTINEOPLASTIC AGENTS; CARBOLINES; CELL DIVISION; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035927235     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00136-6     Document Type: Article

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22. 2O. The DNA bands were detected on a UV light box and photographed with Polaroid 525 film. Controls were no enzyme, enzyme, m-AMSA (100 μM), and DMSO (1%).
23. m-AMSA, the topo II-inhibitor utilized as a control in our DNA relaxation assay, is also a known DNA intercalator.