Two distinct conformational states of Mycobacterium tuberculosis virulent factor early secreted antigenic target 6 kDa are behind the discrepancy around its biological functions

FEBS Journal

Volumn 282, Issue 21, 2015, Pages 4114-4129

  Refai, Amira ^a,b   Haoues, Meriam ^a,b   Othman, Houcemeddine ^a,b   Barbouche, Mohamed Ridha ^a,b   Moua, Philippe ^c   Bondon, Arnaud ^c   Mouret, Liza ^c   Srairi Abid, Najet ^a,b   Essafi, Makram ^a,b  

^a PASTEUR INSTITUTE OF TUNIS   (Tunisia)

^b UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

^c UNIVERSITÉ DE RENNES 1   (France)

Author keywords

biological functions; discrepancy; ESAT 6; structure; tuberculosis

Indexed keywords

AMIDOSULFOBETAINE 14; CULTURE FILTRATE PROTEIN 10; DETERGENT; DIMER; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; HETERODIMER; POLYMER; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; AMIDOSULFOBETAINE-14; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BETAINE; CFP-10 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; ESAT-6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; ESAT-6-CFP10 FUSION PROTEIN; HYBRID PROTEIN; VIRULENCE FACTOR;

ANIMAL CELL; ARTICLE; BACTERIAL VIRULENCE; CELL DEATH; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOKINE RELEASE; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; MACROPHAGE; MEMBRANE FORMATION; MOLECULAR DOCKING; MOLECULAR WEIGHT; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PURIFICATION; PROTEIN TERTIARY STRUCTURE; SIZE EXCLUSION CHROMATOGRAPHY; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; HOST PATHOGEN INTERACTION; PATHOGENICITY; PHYSIOLOGY; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; TUBERCULOSIS; VIRULENCE;

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BETAINE; CELL DEATH; DETERGENTS; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERON-GAMMA; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; RECOMBINANT FUSION PROTEINS; TUBERCULOSIS; VIRULENCE; VIRULENCE FACTORS;

EID: 84945489345     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13408     Document Type: Article

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