Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10

Clinical and Diagnostic Laboratory Immunology

Volumn 7, Issue 2, 2000, Pages 155-160

  Van Pinxteren, Laurens A H ^a   Ravn, Pernille ^a   Agger, Else Marie ^a   Pollock, John ^b   Andersen, Peter ^a  

^a STATENS SERUM INSTITUT   (Denmark)

^b AGRI FOOD AND BIOSCIENCES INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; CFP 10 ANTIGEN; EARLY SECRETORY ANTIGENIC TARGET 6; MYCOBACTERIUM ANTIGEN; TUBERCULIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN RECOGNITION; ARTICLE; BCG VACCINATION; CLINICAL ARTICLE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DIAGNOSTIC ACCURACY; ENVIRONMENTAL EXPOSURE; FEMALE; GUINEA PIG; HUMAN; HUMAN CELL; INTERFERON INDUCTION; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CATTLE; FEMALE; GUINEA PIGS; HUMANS; HYPERSENSITIVITY, DELAYED; MYCOBACTERIUM TUBERCULOSIS; REAGENT KITS, DIAGNOSTIC; TUBERCULIN; TUBERCULOSIS;

EID: 0034008758     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/CDLI.7.2.155-160.2000     Document Type: Article

References (40)

1. Andersen, P. 1994. The T cell response to secreted antigens of Mycobacterium tuberculosis. Immunobiology 191:537-547.
2. Andersen, P., A. B. Andersen, A. L. Sorensen, and S. Nagai. 1995. Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice. J. Immunol. 154:3359-3372.
3. Andersen, P., D. Askgaard, L. Ljungqvist, J. Bennedsen, and I. Heron. 1991. Proteins released from Mycobacterium tuberculosis during growth. Infect. Immun. 59:1905-1910.
4. Berthet, F. X., P. B. Rasmussen, I. Rosenkrands, P. Andersen, and B. Gicquel. 1998. A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10). Microbiology 144:3195-3203.
5. Brandt, L., T. Oettinger, A. Holm, and P. Andersen. 1996. Key epitopes on the ESAT-6 antigen recognized in mice during the recall of protective immunity to Mycobacterium tuberculosis. J. Immunol. 157:3527-3533.
6. Brosch, R., S. V. Gordon, A. Billault, T. Gamier, K. Eiglmeier, C. Soravito, B. G. Barrel, and S. T. Cole. 1998. Use at Mycobacterium tuberculosis H37Rv bacterial artificial chromosome library for genome mapping, sequencing, and comparative genomics. Infect. Immun. 66:2221-2229.
7. Buddle, B. M., N. A. Parlane, D. L. Keen, F. E. Aldwell, J. M. Pollock, K. Lightbody, and P. Andersen. 1999. Differentiation between Mycobacterium bovis BCG-vaccinated and M. bovis-infected cattle by recombinant mycobacterial antigens. Clin. Diagn. Lab. Immunol. 6:1-5.
8. Daborn, C. J., and J. M. Grange. 1993. HIV/AIDS and its implications for the control of animal tuberculosis. Br. Vet. J. 149:405-417.
9. Deuskar, N. J., and M. G. Deo. 1991. Mycobacterial cell surface proteins revealed by labeling with 1251. Int. J. Lepr. Other Mycobact. Dis. 59:482-486.
10. Elhay, M. J., T. Oettinger, and P. Andersen. 1998. Delayed-type hypersensitivity responses to ESAT-6 and MPT64 from Mycobacterium tuberculosis in the guinea pig. Infect. Immun. 66:3454-3456.
11. Enarson, D. A., and F. Murray. 1996. Global epidemiology of tuberculosis. p. 57-75. In W. M. Rom and S. Garay (ed.), Tuberculosis. Brown and Co., Boston, Mass.
12. Fogan, L. 1969. PPD antigens and the diagnosis of mycobacterial diseases. Arch. Intern. Mod. 124:49-54.
13. Harboe, M. 1981. Antigens of PPD. old tuberculin, and autoclaved Mycobacterium bovis BCG studied by crossed immunoelectrophoresis. Am. Rev. Respir. Dis. 124:80-87.
14. Harboe, M., T. Oettinger, H. G. Wiker, I. Rosenkrands, and P. Andersen. 1996. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect. Immun. 64:16-22.
15. Harboe, M., H. G. Wiker, G. Ulvund, A. S. Malin, H. Dockrell, A. Holm, M. C. Jørgensen, and P. Andersen. 1998. B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis. Infect. Immun. 66: 717-723.
16. Lein, A. D., C. F. von-Reyn, P. Ravn, C. R. Horsburgh, L. N. Alexander, and P. Andersen. 1999. Cellular immune responses to ESAT-6 discriminate between patients with pulmonary disease due to Mycobacterium tuberculosis. Clin. Diagn. Lab. Immunol. 6:606-609.
17. Lyashchenko, K., C. Manca, R. Colangeli, A. Heijbel, A. Williams, and M. L. Gennaro. 1998. Use of Mycobacterium tuberculosis complex-specific antigen cocktails for a skin test specific for tuberculosis. Infect. Immun. 66:3606-3610.
18. 17a. Mahairas, G. G., P. J. Sabo, M. J. Hickey, D. C. Singh, and C. K. Stover. 1996. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. J. Bactcriol. 178:1274-1282.
19. Monaghan, M. L., M. L. Doherty, J. D. Collins, J. F. Kazda, and P. J. Quinn. 1994. The tuberculin test. Vet. Microbiol. 40:111-124.
20. Mustafa, A. S., H. A. Amoudy, H. G. Wiker, A. T. Abal, P. Ravn, F. Oftung, and P. Andersen. 1998. Comparison of antigen specific T cell responses of tuberculosis patients using complex or single antigens of Mycobacterium tuberculosis. Scand. J. Immunol. 48:535-543.
21. Nakamura, R. M., M. A. Velmonte, K. Kawajiri, C. F. Ang, R. A. Frias, M. T. Mendoza, J. C. Montoya, I. Honda, S. Haga, and I. Toida. 1998. MPB64 mycobacterial antigen: a new skin-test reagent through patch method for rapid diagnosis of active tuberculosis. Int. J. Tuberc. Lung Dis. 2:541-546.
22. Neill, S. D., J. Hanna, J. J. O'Brien, and R. M. McCracken. 198S. Excretion of Mycobacterium bovis by experimentally infected cattle. Vet. Rec. 123: 340-343.
23. Oettinger, T., A. Holm, I. M. Mtoni, A. B. Andersen, and K. Haslov. 1995. Mapping of the delayed-type hypersensitivity-inducing epitope of secreted protein MPT64 from Mycobacterium tuberculosis. Infect. Immun. 63:4613-4618.
24. Pathan, A., R. Brookes, H. Pritchard, R. Wilkinson, G. Pasvol, A. Hill, and A. Lalvani. 1998. Human T cell responses to the antigen ESAT-6 characterize a vaccine candidate and potential diagnostic test for tuberculosis. Immunology 95(Suppl. 1):90.
25. Pollock, J. M., and P. Andersen. 1997. Predominant recognition of the ESAT-6 protein in the first phase of infection with Mycobacterium bovis in cattle. Infect. Immun. 63:2587-2592.
26. Pollock, J. M., and P. Andersen. 1997. The potential of the ESAT-6 antigen secreted by virulent mycobacteria for specific diagnosis of tuberculosis. J. Infect. Dis. 175:1251-1254.
27. Poulsen, S., and H. Miörner. 1996. Tuberculosis 1995. EPI-NEWS. Statens Serum Institut. Copenhagen, Denmark.
28. Ravn, P., H. Boesen, J. T. Wilcke, and P. Andersen. 1997. Secreted antigens and immune responses to Mycobacterium tuberculosis, p. 74-83. In S. Karger (ed.), Medical principles and practice. Medical and Scientific, London, United Kingdom.
29. Ravn, P., A. Demissie, T. Eguale, H. Wondwosson, D. Lein, H. Amoudy, A. S. Mustafa, A. K. Jensen, A. Holm, I. Rosenkrands, F. Oftung, J. Olobo, C. F. von-Reyn, and P. Andersen. 1999. Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis. J. Infect. Dis. 179:637-645.
30. + lymphocytes from healthy HIV-seropositive and -seronegative individuals. J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol. 12:433-441.
31. Skjøt, R. L. V., T. Oettinger, I. Rosenkrands, P. Ravn, I. Brock, S. Jacobsen, and P. Andersen. 2000. Comparative evaluation of low-molecular-mass T-cell antigens from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant. Infect. Immun. 68:214-220.
32. Sodhi, A., J. Gong, C. Silva, D. Qian, and P. F. Barnes. 1997. Clinical correlates of Interferon gamma production with tuberculosis. Clin. Infect. Dis. 25:617-620.
33. Sorensen, A. L., S. Nagai, G. Houen, P. Andersen, and A. B. Andersen. 1995. Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobactcrium tuberculosis. Infect. Immun. 63:1710-1717.
34. Streeton, J. A. 1995. A blood test reliable for spotting TB infection. TB Weekly 2:3-4.
35. Streeton, J. A., N. Desem, and S. L. Jones. 1998. Sensitivity and specificity of a gamma interferon blood test for tuberculosis infection. Int. J. Tuberc. Lung Dis. 2:443-450.
36. Ulrichs, T., M. E. Munk, H. Mollenkopf, S. Behr-Perst, R. Colangeli, M. L. Gennaro, and S. H. Kaufmann. 1998. Differential T cell responses to Mycobacterium tuberculosis ESAT-6 in tuberculosis patients and healthy donors. Eur. J. Immunol. 28:3949-3958.
37. von-Reyn, C. F., P. A. Green, D. McCormick, G. A. Huitt, B. J. Marsh, M. Magnusson, and T. W. Barber. 1994. Dual skin testing with Mycobacterium avium sensitin and purified protein derivative: an open study of patients with M. avium complex infection or tuberculosis. Clin. Infect. Dis. 19:15-20.
38. Wilcke, J. T., B. N. Jensen, P. Ravn, A. B. Andersen, and K. Haslov. 1996. Clinical evaluation of MPT-64 and MPT-59, two proteins secreted from Mycobacterium tuberculosis, for skin test reagents. Tuber. Lung Dis. 77: 250-256.
39. Wood, P. R., L. A. Corner, and P. Plackett. 1990. Development of a simple, rapid in vitro cellular assay for bovine tuberculosis based on the production of gamma interferon. Res. Vet. Sci. 49:46-49.
40. World Health Organization. 23 March 1999, revision date. Global tuberculosis control - WHO report 1999. [Online.] http://www.who.int. [22 December 1999, last date accessed.]