Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant

Infection and Immunity

Volumn 70, Issue 10, 2002, Pages 5568-5578

  Brodin, Priscille ^a   Eiglmeier, Karin ^a   Marmiesse, Magali ^a   Billault, Alain ^a   Garnier, Thierry ^a   Niemann, Stefan ^a   Cole, Stewart T ^a   Brosch, Roland ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BCG VACCINE; DNA; PHOSPHOLIPASE C; VIRULENCE FACTOR;

ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; BACTERIUM ISOLATION; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DELETION MUTANT; GENETIC ANALYSIS; GENOME ANALYSIS; MOLECULAR CLONING; MYCOBACTERIUM BOVIS; MYCOBACTERIUM MICROTI; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS; VOLE;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BASE SEQUENCE; CHROMOSOMES, ARTIFICIAL, BACTERIAL; DNA, BACTERIAL; GENE DELETION; GENOME, BACTERIAL; HUMANS; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PHOSPHOLIPASE C; SPECIES SPECIFICITY; VARIATION (GENETICS); VIRULENCE;

EID: 0036786509     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.10.5568-5578.2002     Document Type: Article

References (50)

1. Comparative genomics of BCG vaccines by whole-genome DNA microarray
2. A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10)
3. A new evolutionary scenario for the Mycobacterium tuberculosis complex
4. Use of a Mycobacterium tuberculosis H37Rv bacterial artificial chromosome library for genome mapping, sequencing, and comparative genomics
5. Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium boris BCG Pasteur
6. Comparative genomics of the mycobacteria
7. Genomic analysis reveals variation between Mycobacterium tuberculosis H37Rv and the attenuated M. tuberculosis H37Ra strain
8. Immunological characterization of antigens encoded by the RD1 region of the Mycobacterium tuberculosis genome
9. Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis
10. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
11. Massive gene decay in the leprosy bacillus
12. Delayed-type hypersensitivity responses to ESAT-6 and MPT64 from Mycobacterium tuberculosis in the guinea pig
13. Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays
14. Genomics of Mycobacterium bovis
15. B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis
16. BCG and vole bacillus vaccines in the prevention of tuberculosis in adolescence and early adult life
17. Insertion element IS987 from Mycobacterium bovis BCG is located in a hot-spot integration region for insertion elements in Mycobacterium tuberculosis complex strains
18. Comparison of Mycobacterium tuberculosis genomes reveals frequent deletions in a 20 kb variable region in clinical isolates
19. Mycobacterium microti llama-type infection presenting as pulmonary tuberculosis in a human immunodeficiency virus-positive patient
20. Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis
21. Biochemical and molecular analysis of phospholipase C and phospholipase D activity in mycobacteria
22. IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men
23. Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology
24. Comparing genomes within the species Mycobacterium tuberculosis
25. Mycobacterium microti: More widespread than previously thought
26. Comparison of methods based on different molecular epidemiological markers for typing of Mycobacterium tuberculosis complex strains: Interlaboratory study of discriminatory power and reproducibility
27. Proposed minimal standards for the genus Mycobacterium and for description of new slowly growing Mycobacterium spp.
28. Assessment of genetic markers for species differentiation within the Mycobacterium tuberculosis complex
29. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. boris
30. Naturally attenuated, orally administered Mycobacterium microti as a tuberculosis vaccine is better than subcutaneous Mycobacterium bovis BCG
31. Differentiation of clinical Mycobacterium tuberculosis complex isolates by gyrB DNA sequence polymorphism analysis
32. Two cases of Mycobacterium microti-derived tuberculosis in HIV-negative immuno-competent patients
33. Rapid and easy-to-perform identification of Mycobacterium tuberculosis complex isolates using PCR-based genomic deletion analysis
34. Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family
35. Phospholipases C are involved in the virulence of Mycobacterium tuberculosis
36. Identification and characterization of a 29-kilodalton protein from Mycobacterium tuberculosis culture filtrate recognized by mouse memory effector cells
37. Detection of deleted genomic DNA using a semiautomated computational analysis of GeneChip data
38. Bacterial phospholipases and their role in virulence
39. The Staden sequence analysis package
40. Protective effects of M. microti vaccine against tuberculosis
41. PCR identification of Mycobacterium bovis BCG
42. Analysis of the proteome of Mycobacterium tuberculosis in silico
43. Bacterial phospholipases
44. Genetic variation and evolutionary origin of the direct repeat locus of Mycobacterium tuberculosis complex bacteria
45. Diagnosis of Mycobacterium microti infections among humans by using novel genetic markers
46. Phospholipase region of Mycobacterium tuberculosis is a preferential locus for IS6110 transposition
47. An esat6 knockout mutant of Mycobacterium bovis produced by homologous recombination will contribute to the development of a live tuberculosis vaccine
48. Tuberculosis in wild voles
49. The murine type of tubercle bacillus
50. Control and location of acyl-hydro-lysing phospholipase activity in pathogenic mycobacteria