The primary mechanism of attenuation of bacillus Calmette-Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 21, 2003, Pages 12420-12425

  Hsu, Tsungda ^a   Hingley Wilson, Suzanne M ^a   Chen, Bing ^a   Chen, Mei ^a   Dai, Annie Z ^a   Morin, Paul M ^a   Marks, Carolyn B ^a   Padiyar, Jeevan ^a   Goulding, Celia ^b   Gingery, Mari ^b   Eisenberg, David ^b   Russell, Robert G ^a   Derrick, Steven C ^c   Collins, Frank M ^c   Morris, Sheldon L ^c   King, C Harold ^d   Jacobs Jr , William R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CONTROLLED STUDY; CYTOLYSIS; GENE DISRUPTION; GENE MUTATION; GENETIC COMPLEMENTATION; GENETIC TRANSCRIPTION; LUNG ALVEOLUS CELL; LUNG ALVEOLUS MACROPHAGE; LUNG INTERSTITIUM; MALE; MOUSE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPERON; PHENOTYPE; PRIORITY JOURNAL; TRANSPOSON; TUBERCULOSIS; VIRUS VIRULENCE;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BCG VACCINE; CELL LINE; GENE DELETION; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; HUMANS; LUNG; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, SCID; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; OPERON; VIRULENCE;

ACTINOBACTERIA (CLASS); ANIMALIA; MYCOBACTERIUM; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS; TRANSPOSONS; UNCULTURED ACTINOMYCETE;

EID: 0142059794     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1635213100     Document Type: Article

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