메뉴 건너뛰기




Volumn 60, Issue 6, 2015, Pages 806-821

Aerosolized medications for gene and peptide therapy

Author keywords

Aerosol non viral vectors; Aerosol viral vectors; Alpha 1 antitrypsin; Cystic fibrosis (CF); Glutathione (GSH); Granulocyte macrophage colony stimulating factor (GM CSF); Insulin; Interfering RNA; Lung cancer; Vasoactive intestinal peptide

Indexed keywords

AEROSOLIZED PEPTIDE; ALPHA 1 ANTITRYPSIN; CALCITONIN; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GLUTATHIONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INSULIN; LIPOSOME; NANOPARTICLE; PEPTIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; VIRUS VECTOR; AEROSOL; NUCLEIC ACID;

EID: 84944729759     PISSN: 00201324     EISSN: 19433654     Source Type: Journal    
DOI: 10.4187/respcare.03554     Document Type: Article
Times cited : (26)

References (141)
  • 1
    • 67349204836 scopus 로고    scopus 로고
    • Biological gene delivery vehicles: Beyond viral vectors
    • Seow Y, Wood MJ. Biological gene delivery vehicles: beyond viral vectors. Mol Ther 2009;17(5):767-777.
    • (2009) Mol Ther , vol.17 , Issue.5 , pp. 767-777
    • Seow, Y.1    Wood, M.J.2
  • 2
    • 84879670765 scopus 로고    scopus 로고
    • Delivery systems for gene therapy
    • Mali S. Delivery systems for gene therapy. Indian J Hum Genet 2013;19(1):3-8.
    • (2013) Indian J Hum Genet , vol.19 , Issue.1 , pp. 3-8
    • Mali, S.1
  • 3
    • 84866935335 scopus 로고    scopus 로고
    • Vectors for inhaled gene therapy in lung cancer. Application for nano oncology and safety of bio nanotechnology
    • Zarogouldis P, Karamanos NK, Porpodis K, Domvri K, Huang H, Hohenforst-Schmidt W, et al. Vectors for inhaled gene therapy in lung cancer. Application for nano oncology and safety of bio nanotechnology. Int J Mol Sci 2012;13(9):10828-10862.
    • (2012) Int J Mol Sci , vol.13 , Issue.9 , pp. 10828-10862
    • Zarogouldis, P.1    Karamanos, N.K.2    Porpodis, K.3    Domvri, K.4    Huang, H.5    Hohenforst-Schmidt, W.6
  • 4
    • 33644627889 scopus 로고    scopus 로고
    • The expanding role of aerosols in systemic drug delivery, gene therapy, and vaccination
    • Laube BL. The expanding role of aerosols in systemic drug delivery, gene therapy, and vaccination. Respir Care 2005;50(9):1161-1176.
    • (2005) Respir Care , vol.50 , Issue.9 , pp. 1161-1176
    • Laube, B.L.1
  • 5
    • 77957343707 scopus 로고    scopus 로고
    • Chemical vectors for gene delivery: Uptake and intracellular trafficking
    • Pichon C, Billiet L, Midoux P. Chemical vectors for gene delivery: uptake and intracellular trafficking. Curr Opin Biotechnol 2010; 21(5):640-645.
    • (2010) Curr Opin Biotechnol , vol.21 , Issue.5 , pp. 640-645
    • Pichon, C.1    Billiet, L.2    Midoux, P.3
  • 6
    • 84873888481 scopus 로고    scopus 로고
    • Expert opinion in biological therapy: Update on developments in lung gene transfer
    • Griesenbach U, Alton EW. Expert opinion in biological therapy: update on developments in lung gene transfer. Expert Opin Biol Ther 2013;13(3):345-360.
    • (2013) Expert Opin Biol Ther , vol.13 , Issue.3 , pp. 345-360
    • Griesenbach, U.1    Alton, E.W.2
  • 7
    • 84856488316 scopus 로고    scopus 로고
    • Progress in gene and cell therapy for cystic fibrosis lung disease
    • Griesenbach U, Alton EW. Progress in gene and cell therapy for cystic fibrosis lung disease. Curr Pharm Des 2012;18(5):642-662.
    • (2012) Curr Pharm Des , vol.18 , Issue.5 , pp. 642-662
    • Griesenbach, U.1    Alton, E.W.2
  • 8
    • 77950550189 scopus 로고    scopus 로고
    • Comparison of the type of liposome involving cytokine production induced by non-CpG Lipoplex in macrophages
    • Yasuda S, Yoshida H, Nishikawa M, Takakura Y. Comparison of the type of liposome involving cytokine production induced by non-CpG Lipoplex in macrophages. Mol Pharm 2010;7(2):533-542.
    • (2010) Mol Pharm , vol.7 , Issue.2 , pp. 533-542
    • Yasuda, S.1    Yoshida, H.2    Nishikawa, M.3    Takakura, Y.4
  • 9
    • 84944718696 scopus 로고    scopus 로고
    • RCSB PDB-101, Accessed May 12, 2014
    • Goodsell D. Small interfering RNA (siRNA). RCSB PDB-101, 2008. http://www.rcsb.org/pdb/101/motm.do?momID_98&print_1. Accessed May 12, 2014.
    • (2008) Small Interfering RNA (Sirna)
    • Goodsell, D.1
  • 10
    • 0036351317 scopus 로고    scopus 로고
    • Analysis of gene function in somatic mammalian cells using small interfering RNAs
    • Elbashir SM, Harborth J, Weber K, Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 2002;26(2):199-213.
    • (2002) Methods , vol.26 , Issue.2 , pp. 199-213
    • Elbashir, S.M.1    Harborth, J.2    Weber, K.3    Tuschl, T.4
  • 11
    • 0037089135 scopus 로고    scopus 로고
    • Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor
    • Holen T, Amarzguioui M, Wiiger MT, Babaie E, Prydz H. Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor. Nucleic Acids Res 2002;30(8):1757-1766.
    • (2002) Nucleic Acids Res , vol.30 , Issue.8 , pp. 1757-1766
    • Holen, T.1    Amarzguioui, M.2    Wiiger, M.T.3    Babaie, E.4    Prydz, H.5
  • 12
    • 0038265000 scopus 로고    scopus 로고
    • RNAi as a gene therapy approach
    • Caplen NJ. RNAi as a gene therapy approach. Expert Opin Biol Ther 2003;3(4):575-586.
    • (2003) Expert Opin Biol Ther , vol.3 , Issue.4 , pp. 575-586
    • Caplen, N.J.1
  • 13
    • 0037089589 scopus 로고    scopus 로고
    • Short hairpin RNAs (ShRNAs) induce sequence-specific silencing in mammalian cells
    • Paddison PJ, Caudy AA, Bernstein E, Hannon GJ, Conklin DS. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev 2002;16(8):948-958.
    • (2002) Genes Dev , vol.16 , Issue.8 , pp. 948-958
    • Paddison, P.J.1    Caudy, A.A.2    Bernstein, E.3    Hannon, G.J.4    Conklin, D.S.5
  • 16
    • 0037470145 scopus 로고    scopus 로고
    • Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis
    • Vickers TA, Koo S, Bennett CF, Crooke ST, Dean NM, Baker BF. Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis. J Biol Chem 2003;278(9):7108-7118.
    • (2003) J Biol Chem , vol.278 , Issue.9 , pp. 7108-7118
    • Vickers, T.A.1    Koo, S.2    Bennett, C.F.3    Crooke, S.T.4    Dean, N.M.5    Baker, B.F.6
  • 17
    • 0037280401 scopus 로고    scopus 로고
    • RNA interference may be more potent than antisense RNA in human cancer cell lines
    • Aoki Y, Cioca DP, Oidaira H, Kamiya J, Kiyosawa K. RNA interference may be more potent than antisense RNA in human cancer cell lines. Clin Exp Pharmacol Physiol 2003;30(1-2):96-102.
    • (2003) Clin Exp Pharmacol Physiol , vol.30 , Issue.1-2 , pp. 96-102
    • Aoki, Y.1    Cioca, D.P.2    Oidaira, H.3    Kamiya, J.4    Kiyosawa, K.5
  • 18
    • 24144445346 scopus 로고    scopus 로고
    • Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells
    • Miyagishi M, Hayashi M, Taira K. Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. Antisense Nucleic Acid Drug Dev 2003;13(1):1-7.
    • (2003) Antisense Nucleic Acid Drug Dev , vol.13 , Issue.1 , pp. 1-7
    • Miyagishi, M.1    Hayashi, M.2    Taira, K.3
  • 19
    • 17144386185 scopus 로고    scopus 로고
    • Small interfering RNA for experimental cancer therapy
    • Tong AW, Zhang YA, Nemunaitis J. Small interfering RNA for experimental cancer therapy. Curr Opin Mol Ther 2005;7(2):114-124.
    • (2005) Curr Opin Mol Ther , vol.7 , Issue.2 , pp. 114-124
    • Tong, A.W.1    Zhang, Y.A.2    Nemunaitis, J.3
  • 20
    • 34250351911 scopus 로고    scopus 로고
    • Toward therapies tailored to patient characteristics
    • Novello S, Longo M, Levra MG. Toward therapies tailored to patient characteristics. J Thorac Oncol 2007;2(5 Suppl):S38-S41.
    • (2007) J Thorac Oncol , vol.2 , Issue.5 , pp. S38-S41
    • Novello, S.1    Longo, M.2    Levra, M.G.3
  • 21
    • 84857076353 scopus 로고    scopus 로고
    • Targeted therapy in lung cancer: Lessons learned from past experiences
    • Subramanian J, Waqar SN, Govindan R. Targeted therapy in lung cancer: lessons learned from past experiences. J Thorac Oncol 2011; 6(11 Suppl 4):S1786-S1788.
    • (2011) J Thorac Oncol , vol.6 , Issue.11 , pp. S1786-S1788
    • Subramanian, J.1    Waqar, S.N.2    Govindan, R.3
  • 22
  • 23
    • 33746491709 scopus 로고    scopus 로고
    • Drug penetration in solid tumours
    • Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat Rev Cancer 2006;6(8):583-592.
    • (2006) Nat Rev Cancer , vol.6 , Issue.8 , pp. 583-592
    • Minchinton, A.I.1    Tannock, I.F.2
  • 24
    • 0020773403 scopus 로고
    • New chemotherapeutic method for the treatment of tracheal and bronchial cancers—nebulization chemotherapy
    • Article in Japanese
    • Tatsumura T, Yamamoto K, Murakami A, Tsuda M, Sugiyama S. [New chemotherapeutic method for the treatment of tracheal and bronchial cancers—nebulization chemotherapy]. Gan No Rinsho 1983;29(7):765-770. Article in Japanese.
    • (1983) Gan No Rinsho , vol.29 , Issue.7 , pp. 765-770
    • Tatsumura, T.1    Yamamoto, K.2    Murakami, A.3    Tsuda, M.4    Sugiyama, S.5
  • 25
    • 0027421114 scopus 로고
    • Further study of nebulisation chemotherapy, a new chemotherapeutic method in the treatment of lung carcinomas: Fundamental and clinical
    • Tatsumura T, Koyama S, Tsujimoto M, Kitagawa M, Kagamimori S. Further study of nebulisation chemotherapy, a new chemotherapeutic method in the treatment of lung carcinomas: fundamental and clinical. Br J Cancer 1993;68(6):1146-1149.
    • (1993) Br J Cancer , vol.68 , Issue.6 , pp. 1146-1149
    • Tatsumura, T.1    Koyama, S.2    Tsujimoto, M.3    Kitagawa, M.4    Kagamimori, S.5
  • 26
    • 0042129873 scopus 로고    scopus 로고
    • Paclitaxel (Taxol) and taxoid derivates for lung cancer treatment: Potential for aerosol delivery
    • Gautam A, Koshkina N. Paclitaxel (Taxol) and taxoid derivates for lung cancer treatment: potential for aerosol delivery. Curr Cancer Drug Targets 2003;3(4):287-296.
    • (2003) Curr Cancer Drug Targets , vol.3 , Issue.4 , pp. 287-296
    • Gautam, A.1    Koshkina, N.2
  • 27
    • 0032853556 scopus 로고    scopus 로고
    • Inhalation chemotherapy for macroscopic primary or metastatic lung tumors: Proof of principle using dogs with spontaneously occurring tumors as a model
    • Hershey AE, Kurzman ID, Forrest LJ, Bohling CA, Stonerook M, Placke ME, et al. Inhalation chemotherapy for macroscopic primary or metastatic lung tumors: proof of principle using dogs with spontaneously occurring tumors as a model. Clin Cancer Res 1999;5(9): 2653-2659.
    • (1999) Clin Cancer Res , vol.5 , Issue.9 , pp. 2653-2659
    • Hershey, A.E.1    Kurzman, I.D.2    Forrest, L.J.3    Bohling, C.A.4    Stonerook, M.5    Placke, M.E.6
  • 28
    • 1942533024 scopus 로고    scopus 로고
    • Cyclosporin A aerosol improves the anticancer effect of paclitaxel aerosol in mice
    • Koshkina NV, Golunski E, Roberts LE, Gilbert BE, Knight V. Cyclosporin A aerosol improves the anticancer effect of paclitaxel aerosol in mice. J Aerosol Med 2004;17(1):7-14.
    • (2004) J Aerosol Med , vol.17 , Issue.1 , pp. 7-14
    • Koshkina, N.V.1    Golunski, E.2    Roberts, L.E.3    Gilbert, B.E.4    Knight, V.5
  • 29
    • 0021256244 scopus 로고
    • Pharmacokinetics of doxorubicin in isolated lung of dogs and humans perfused in vivo
    • Minchin RF, Johnston MR, Aiken MA, Boyd MR. Pharmacokinetics of doxorubicin in isolated lung of dogs and humans perfused in vivo. J Pharmacol Exp Ther 1984;229(1):193-198.
    • (1984) J Pharmacol Exp Ther , vol.229 , Issue.1 , pp. 193-198
    • Minchin, R.F.1    Johnston, M.R.2    Aiken, M.A.3    Boyd, M.R.4
  • 30
    • 27844562815 scopus 로고    scopus 로고
    • Spraydried poly(D,L-lactide) microspheres containing carboplatin for veterinary use: In vitro and in vivo studies
    • Gavini E, Manunta L, Giua S, Achenza G, Giunchedi P. Spraydried poly(D,L-lactide) microspheres containing carboplatin for veterinary use: in vitro and in vivo studies. AAPS PharmSci Tech 2005;6(1):E108–E114.
    • (2005) AAPS Pharmsci Tech , vol.6 , Issue.1 , pp. E108-E114
    • Gavini, E.1    Manunta, L.2    Giua, S.3    Achenza, G.4    Giunchedi, P.5
  • 31
    • 0041629016 scopus 로고    scopus 로고
    • Targeting the lung: Preclinical and comparative evaluation of anticancer aerosols in dogs with naturally occurring cancers
    • Khanna C, Vail DM. Targeting the lung: preclinical and comparative evaluation of anticancer aerosols in dogs with naturally occurring cancers. Curr Cancer Drug Targets 2003;3(4):265-273.
    • (2003) Curr Cancer Drug Targets , vol.3 , Issue.4 , pp. 265-273
    • Khanna, C.1    Vail, D.M.2
  • 33
    • 54949096176 scopus 로고    scopus 로고
    • Feasibility and safety of targeted cisplatin delivery to a select lung lobe in dogs via the AeroProbe intracorporeal nebulization catheter
    • Selting K, Waldrep JC, Reinero C, Branson K, Gustafson D, Kim DY, et al. Feasibility and safety of targeted cisplatin delivery to a select lung lobe in dogs via the AeroProbe intracorporeal nebulization catheter. J Aerosol Med Pulm Drug Deliv 2008;21(3):255-268.
    • (2008) J Aerosol Med Pulm Drug Deliv , vol.21 , Issue.3 , pp. 255-268
    • Selting, K.1    Waldrep, J.C.2    Reinero, C.3    Branson, K.4    Gustafson, D.5    Kim, D.Y.6
  • 34
    • 33750956761 scopus 로고    scopus 로고
    • Assessing a system to capture stray aerosol during inhalation of nebulized liposomal cisplatin
    • Wittgen BP, Kunst PW, Perkins WR, Lee JK, Postmus PE. Assessing a system to capture stray aerosol during inhalation of nebulized liposomal cisplatin. J Aerosol Med 2006;19(3):385-391.
    • (2006) J Aerosol Med , vol.19 , Issue.3 , pp. 385-391
    • Wittgen, B.P.1    Kunst, P.W.2    Perkins, W.R.3    Lee, J.K.4    Postmus, P.E.5
  • 36
    • 74349091948 scopus 로고    scopus 로고
    • Pulmonary targeting microparticulate camptothecin delivery system: Anticancer evaluation in a rat orthotopic lung cancer model
    • Chao P, Deshmukh M, Kutscher HL, Gao D, Rajan SS, Hu P, et al. Pulmonary targeting microparticulate camptothecin delivery system: anticancer evaluation in a rat orthotopic lung cancer model. Anticancer Drugs 2010;21(1):65-76.
    • (2010) Anticancer Drugs , vol.21 , Issue.1 , pp. 65-76
    • Chao, P.1    Deshmukh, M.2    Kutscher, H.L.3    Gao, D.4    Rajan, S.S.5    Hu, P.6
  • 37
    • 67349255031 scopus 로고    scopus 로고
    • The use of biotinylated-EGF-modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation
    • Tseng CL, Su WY, Yen KC, Yang KC, Lin FH. The use of biotinylated-EGF-modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation. Biomaterials 2009;30(20):3476-3485.
    • (2009) Biomaterials , vol.30 , Issue.20 , pp. 3476-3485
    • Tseng, C.L.1    Su, W.Y.2    Yen, K.C.3    Yang, K.C.4    Lin, F.H.5
  • 38
    • 78149232478 scopus 로고    scopus 로고
    • Uptake of all-trans retinoic acid-containing aerosol by inhalation to lungs in a guinea pig model system—a pilot study
    • Schäffer MW, Roy SS, Mukherjee S, Ong DE, Das SK. Uptake of all-trans retinoic acid-containing aerosol by inhalation to lungs in a guinea pig model system—a pilot study. Exp Lung Res 2010;36(10): 593-601.
    • (2010) Exp Lung Res , vol.36 , Issue.10 , pp. 593-601
    • Schäffer, M.W.1    Roy, S.S.2    Mukherjee, S.3    Ong, D.E.4    Das, S.K.5
  • 41
    • 10044264288 scopus 로고    scopus 로고
    • Alpha-TEA plus cisplatin reduces human cisplatinresistant ovarian cancer cell tumor burden and metastasis
    • Anderson K, Lawson KA, Simmons-Menchaca M, Sun L, Sanders BG, Kline K. Alpha-TEA plus cisplatin reduces human cisplatinresistant ovarian cancer cell tumor burden and metastasis. Exp Biol Med 2004;229(11):1169-1176.
    • (2004) Exp Biol Med , vol.229 , Issue.11 , pp. 1169-1176
    • Anderson, K.1    Lawson, K.A.2    Simmons-Menchaca, M.3    Sun, L.4    Sanders, B.G.5    Kline, K.6
  • 42
    • 0034787791 scopus 로고    scopus 로고
    • Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model
    • Koshkina NV, Waldrep JC, Roberts LE, Golunski E, Melton S, Knight V. Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model. Clin Cancer Res 2001;7(10):3258-3262.
    • (2001) Clin Cancer Res , vol.7 , Issue.10 , pp. 3258-3262
    • Koshkina, N.V.1    Waldrep, J.C.2    Roberts, L.E.3    Golunski, E.4    Melton, S.5    Knight, V.6
  • 43
    • 77953766334 scopus 로고    scopus 로고
    • Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance
    • Garbuzenko OB, Saad M, Pozharov VP, Reuhl KR, Mainelis G, Minko T. Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance. Proc Natl Acad Sci USA 2010;107(23):10737-10742.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.23 , pp. 10737-10742
    • Garbuzenko, O.B.1    Saad, M.2    Pozharov, V.P.3    Reuhl, K.R.4    Mainelis, G.5    Minko, T.6
  • 44
    • 1942538547 scopus 로고    scopus 로고
    • Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil
    • Wattenberg LW, Wiedmann TS, Estensen RD. Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil. Cancer Res 2004;64(7):2347-2349.
    • (2004) Cancer Res , vol.64 , Issue.7 , pp. 2347-2349
    • Wattenberg, L.W.1    Wiedmann, T.S.2    Estensen, R.D.3
  • 46
    • 7744226289 scopus 로고    scopus 로고
    • Novel vitamin E analogue and 9-nitrocamptothecin administered as liposome aerosols decrease syngeneic mouse mammary tumor burden and inhibit metastasis
    • Lawson KA, Anderson K, Snyder RM, Simmons-Menchaca M, Atkinson J, Sun LZ, et al. Novel vitamin E analogue and 9-nitrocamptothecin administered as liposome aerosols decrease syngeneic mouse mammary tumor burden and inhibit metastasis. Cancer Chemother Pharmacol 2004;54(5):421-431.
    • (2004) Cancer Chemother Pharmacol , vol.54 , Issue.5 , pp. 421-431
    • Lawson, K.A.1    Erson, K.2    Snyder, R.M.3    Simmons-Menchaca, M.4    Atkinson, J.5    Sun, L.Z.6
  • 47
    • 67349131897 scopus 로고    scopus 로고
    • Combination chemotherapeutic dry powder aerosols via controlled nanoparticle agglomeration
    • El-Gendy N, Berkland C. Combination chemotherapeutic dry powder aerosols via controlled nanoparticle agglomeration. Pharm Res 2009;26(7):1752-1763.
    • (2009) Pharm Res , vol.26 , Issue.7 , pp. 1752-1763
    • El-Gendy, N.1    Berkland, C.2
  • 48
    • 33745904988 scopus 로고    scopus 로고
    • Formulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particles
    • Azarmi S, Tao X, Chen H, Wang Z, Finlay WH, Löbenberg R, Roa WH. Formulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particles. Int J Pharm 2006;319(1-2):155-161.
    • (2006) Int J Pharm , vol.319 , Issue.1-2 , pp. 155-161
    • Azarmi, S.1    Tao, X.2    Chen, H.3    Wang, Z.4    Finlay, W.H.5    Löbenberg, R.6    Roa, W.H.7
  • 49
    • 33745026711 scopus 로고    scopus 로고
    • Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipidcoated nanoparticles
    • Hitzman CJ, Wattenberg LW, Wiedmann TS. Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipidcoated nanoparticles. J Pharm Sci 2006;95(6):1196-1211.
    • (2006) J Pharm Sci , vol.95 , Issue.6 , pp. 1196-1211
    • Hitzman, C.J.1    Wattenberg, L.W.2    Wiedmann, T.S.3
  • 53
  • 54
    • 1842479077 scopus 로고    scopus 로고
    • Clinical evaluation of the delivery and safety of aerosolized liposomal 9-nitro-20(S)-camptothecin in patients with advanced pulmonary malignancies
    • Verschraegen CF, Gilbert BE, Loyer E, Huaringa A, Walsh G, Newman RA, Knight V. Clinical evaluation of the delivery and safety of aerosolized liposomal 9-nitro-20(S)-camptothecin in patients with advanced pulmonary malignancies. Clin Cancer Res 2004;10(7):2319-2326.
    • (2004) Clin Cancer Res , vol.10 , Issue.7 , pp. 2319-2326
    • Verschraegen, C.F.1    Gilbert, B.E.2    Loyer, E.3    Huaringa, A.4    Walsh, G.5    Newman, R.A.6    Knight, V.7
  • 56
    • 0037158901 scopus 로고    scopus 로고
    • Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi)
    • Wilda M, Fuchs U, Wössmann W, Borkhardt A. Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene 2002;21(37):5716-5724.
    • (2002) Oncogene , vol.21 , Issue.37 , pp. 5716-5724
    • Wilda, M.1    Fuchs, U.2    Wössmann, W.3    Borkhardt, A.4
  • 57
    • 0037441756 scopus 로고    scopus 로고
    • Specific inhibition of bcr-abl gene expression by small interfering RNA
    • Scherr M, Battmer K, Winkler T, Heidenreich O, Ganser A, Eder M. Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood 2003;101(4):1566-1569.
    • (2003) Blood , vol.101 , Issue.4 , pp. 1566-1569
    • Scherr, M.1    Battmer, K.2    Winkler, T.3    Heidenreich, O.4    Ganser, A.5    Eder, M.6
  • 58
    • 0036726313 scopus 로고    scopus 로고
    • Stable suppression of tumorigenicity by virus-mediated RNA interference
    • Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2002;2(3):243-247.
    • (2002) Cancer Cell , vol.2 , Issue.3 , pp. 243-247
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 59
    • 0344211452 scopus 로고    scopus 로고
    • Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer
    • Zhang L, Yang N, Mohamed-Hadley A, Rubin SC, Coukos G. Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer. Biochem Biophys Res Commun 2003;303(4):1169-1178.
    • (2003) Biochem Biophys Res Commun , vol.303 , Issue.4 , pp. 1169-1178
    • Zhang, L.1    Yang, N.2    Mohamed-Hadley, A.3    Rubin, S.C.4    Coukos, G.5
  • 60
    • 0037446068 scopus 로고    scopus 로고
    • Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (ErbB1) and induce apoptosis in erbB1-overexpressing cells
    • Nagy P, Arndt-Jovin DJ, Jovin TM. Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells. Exp Cell Res 2003;285(1):39-49.
    • (2003) Exp Cell Res , vol.285 , Issue.1 , pp. 39-49
    • Nagy, P.1    Arndt-Jovin, D.J.2    Jovin, T.M.3
  • 61
    • 0037380839 scopus 로고    scopus 로고
    • Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells
    • Wu H, Hait WN, Yang JM. Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells. Cancer Res 2003;63(7):1515-1519.
    • (2003) Cancer Res , vol.63 , Issue.7 , pp. 1515-1519
    • Wu, H.1    Hait, W.N.2    Yang, J.M.3
  • 63
    • 33750699301 scopus 로고    scopus 로고
    • Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death
    • Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, et al. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med 2006;12(11):1286-1293.
    • (2006) Nat Med , vol.12 , Issue.11 , pp. 1286-1293
    • Bhandari, V.1    Choo-Wing, R.2    Lee, C.G.3    Zhu, Z.4    Nedrelow, J.H.5    Chupp, G.L.6
  • 64
    • 20044385081 scopus 로고    scopus 로고
    • In vivo gene silencing (With siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury
    • Lomas-Neira JL, Chung CS, Wesche DE, Perl M, Ayala A. In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury. J Leukoc Biol 2005;77(6): 846-853.
    • (2005) J Leukoc Biol , vol.77 , Issue.6 , pp. 846-853
    • Lomas-Neira, J.L.1    Chung, C.S.2    Wesche, D.E.3    Perl, M.4    Ayala, A.5
  • 65
    • 31144476253 scopus 로고    scopus 로고
    • Suppression of discoidin domain receptor 1 by RNA interference attenuates lung inflammation
    • Matsuyama W, Watanabe M, Shirahama Y, Hirano R, Mitsuyama H, Higashimoto I, et al. Suppression of discoidin domain receptor 1 by RNA interference attenuates lung inflammation. J Immunol 2006;176(3):1928-1936.
    • (2006) J Immunol , vol.176 , Issue.3 , pp. 1928-1936
    • Matsuyama, W.1    Watanabe, M.2    Shirahama, Y.3    Hirano, R.4    Mitsuyama, H.5    Higashimoto, I.6
  • 68
    • 0023898432 scopus 로고
    • Molecular basis of alpha-1 antitrypsin deficiency
    • Brantly M, Nukiwa T, Crystal RG. Molecular basis of alpha-1 antitrypsin deficiency. Am J Med 1988;84(6A):13-31.
    • (1988) Am J Med , vol.84 , Issue.6A , pp. 13-31
    • Brantly, M.1    Nukiwa, T.2    Crystal, R.G.3
  • 70
    • 0035823595 scopus 로고    scopus 로고
    • The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature
    • Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, et al. The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem 2001;276(36):33293-33296.
    • (2001) J Biol Chem , vol.276 , Issue.36 , pp. 33293-33296
    • Silverman, G.A.1    Bird, P.I.2    Carrell, R.W.3    Church, F.C.4    Coughlin, P.B.5    Gettins, P.G.6
  • 72
    • 0036433482 scopus 로고    scopus 로고
    • Worldwide racial and ethnic distribution of alpha-1 antitrypsin deficiency: Summary of an analysis of published genetic epidemiologic surveys
    • de Serres FJ. Worldwide racial and ethnic distribution of alpha-1 antitrypsin deficiency: summary of an analysis of published genetic epidemiologic surveys. Chest 2002;122(5):1818-1829.
    • (2002) Chest , vol.122 , Issue.5 , pp. 1818-1829
    • De Serres, F.J.1
  • 73
    • 6344221451 scopus 로고    scopus 로고
    • Alpha-1 antitrypsin deficiency. 6: New and emerging treatments for alpha-1 antitrypsin deficiency
    • Sandhaus RA. Alpha-1 antitrypsin deficiency. 6: New and emerging treatments for alpha-1 antitrypsin deficiency. Thorax 2004; 59(10):904-909.
    • (2004) Thorax , vol.59 , Issue.10 , pp. 904-909
    • Sandhaus, R.A.1
  • 74
    • 0025360692 scopus 로고
    • Strategies for aerosol therapy of alpha-1 antitrypsin deficiency by the aerosol route
    • Hubbard RC, Crystal RG. Strategies for aerosol therapy of alpha-1 antitrypsin deficiency by the aerosol route. Lung 1990;168(Suppl): 565-578.
    • (1990) Lung , vol.168 , pp. 565-578
    • Hubbard, R.C.1    Crystal, R.G.2
  • 75
    • 0024403417 scopus 로고
    • Anti-neutrophil-elastase defenses of the lower respiratory tract in alpha-1 antitrypsin deficiency directly augmented with an aerosol of alpha-1 antitrypsin
    • Hubbard RC, Brantly ML, Sellers SE, Mitchell ME, Crystal RG. Anti-neutrophil-elastase defenses of the lower respiratory tract in alpha-1 antitrypsin deficiency directly augmented with an aerosol of alpha-1 antitrypsin. Ann Intern Med 1989;111(3):206-212.
    • (1989) Ann Intern Med , vol.111 , Issue.3 , pp. 206-212
    • Hubbard, R.C.1    Brantly, M.L.2    Sellers, S.E.3    Mitchell, M.E.4    Crystal, R.G.5
  • 76
    • 0024417082 scopus 로고
    • Recombinant DNA-produced alpha-1 antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha-1 antitrypsin deficiency
    • Hubbard RC, McElvaney NG, Sellers SE, Healy JT, Czerski DB, Crystal RG. Recombinant DNA-produced alpha-1 antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha-1 antitrypsin deficiency. J Clin Invest 1989;84(4):1349-1354.
    • (1989) J Clin Invest , vol.84 , Issue.4 , pp. 1349-1354
    • Hubbard, R.C.1    McElvaney, N.G.2    Sellers, S.E.3    Healy, J.T.4    Czerski, D.B.5    Crystal, R.G.6
  • 78
    • 84878678178 scopus 로고    scopus 로고
    • Recent advances in alpha-1 antitrypsin deficiency-related lung disease
    • Brebner JA, Stockley RA. Recent advances in alpha-1 antitrypsin deficiency-related lung disease. Expert Rev Respir Med 2013;7(3): 213-229.
    • (2013) Expert Rev Respir Med , vol.7 , Issue.3 , pp. 213-229
    • Brebner, J.A.1    Stockley, R.A.2
  • 79
    • 69249120315 scopus 로고    scopus 로고
    • Lung deposition of inhaled alpha-1 proteinase inhibitor in cystic fibrosis and alpha-1 antitrypsin deficiency
    • Brand P, Schulte M, Wencker M, Herpich CH, Klein G, Hanna K, Meyer T. Lung deposition of inhaled alpha-1 proteinase inhibitor in cystic fibrosis and alpha-1 antitrypsin deficiency. Eur Respir J 2009; 34(2):354-360.
    • (2009) Eur Respir J , vol.34 , Issue.2 , pp. 354-360
    • Brand, P.1    Schulte, M.2    Wencker, M.3    Herpich, C.H.4    Klein, G.5    Hanna, K.6    Meyer, T.7
  • 80
    • 77950626190 scopus 로고    scopus 로고
    • The I-neb adaptive aerosol delivery system enhances delivery of alpha-1 antitrypsin with controlled inhalation
    • Geller DE, Kesser KC. The I-neb adaptive aerosol delivery system enhances delivery of alpha-1 antitrypsin with controlled inhalation. J Aerosol Med Pulm Drug Deliv 2010;23(Suppl 1):S55-S59.
    • (2010) J Aerosol Med Pulm Drug Deliv , vol.23 , pp. S55-S59
    • Geller, D.E.1    Kesser, K.C.2
  • 81
    • 0035034105 scopus 로고    scopus 로고
    • Asialofetuin liposome-mediated human alpha-1 antitrypsin gene transfer in vivo results in stationary long-term gene expression
    • Dasí F, Benet M, Crespo J, Crespo A, Aliño SF. Asialofetuin liposome-mediated human alpha-1 antitrypsin gene transfer in vivo results in stationary long-term gene expression. J Mol Med 2001; 79(4):205-212.
    • (2001) J Mol Med , vol.79 , Issue.4 , pp. 205-212
    • Dasí, F.1    Benet, M.2    Crespo, J.3    Crespo, A.4    Aliño, S.F.5
  • 82
    • 0025848772 scopus 로고
    • Adenovirus-mediated transfer of a recombinant alpha-1 antitrypsin gene to the lung epithelium in vivo
    • Rosenfeld MA, Siegfried W, Yoshimura K, Yoneyama K, Fukayama M, Stier LE, et al. Adenovirus-mediated transfer of a recombinant alpha-1 antitrypsin gene to the lung epithelium in vivo. Science 1991;252(5004):431-434.
    • (1991) Science , vol.252 , Issue.5004 , pp. 431-434
    • Rosenfeld, M.A.1    Siegfried, W.2    Yoshimura, K.3    Yoneyama, K.4    Fukayama, M.5    Stier, L.E.6
  • 83
    • 0028899573 scopus 로고
    • Therapeutic serum concentrations of human alpha-1 antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes
    • Kay MA, Graham F, Leland F, Woo SL. Therapeutic serum concentrations of human alpha-1 antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Hepatology 1995;21(3):815-819.
    • (1995) Hepatology , vol.21 , Issue.3 , pp. 815-819
    • Kay, M.A.1    Graham, F.2    Leland, F.3    Woo, S.L.4
  • 84
    • 0029113869 scopus 로고
    • Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration
    • Kay MA, Holterman AX, Meuse L, Gown A, Ochs HD, Linsley PS, Wilson CB. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nat Genet 1995; 11(2):191-197.
    • (1995) Nat Genet , vol.11 , Issue.2 , pp. 191-197
    • Kay, M.A.1    Holterman, A.X.2    Meuse, L.3    Gown, A.4    Ochs, H.D.5    Linsley, P.S.6    Wilson, C.B.7
  • 85
    • 0028418190 scopus 로고
    • Intraperitoneal in vivo gene therapy to deliver alpha-1 antitrypsin to the systemic circulation
    • Setoguchi Y, Jaffe HA, Chu CS, Crystal RG. Intraperitoneal in vivo gene therapy to deliver alpha-1 antitrypsin to the systemic circulation. Am J Respir Cell Mol Biol 1994;10(4):369-377.
    • (1994) Am J Respir Cell Mol Biol , vol.10 , Issue.4 , pp. 369-377
    • Setoguchi, Y.1    Jaffe, H.A.2    Chu, C.S.3    Crystal, R.G.4
  • 86
    • 0029875289 scopus 로고    scopus 로고
    • Characterization of plasmid DNA transfer into mouse skeletal muscle: Evaluation of uptake mechanism, expression and secretion of gene products into blood
    • Levy MY, Barron LG, Meyer KB, Szoka FC Jr. Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Ther 1996;3(3):201-211.
    • (1996) Gene Ther , vol.3 , Issue.3 , pp. 201-211
    • Levy, M.Y.1    Barron, L.G.2    Meyer, K.B.3    Szoka, F.C.4
  • 87
    • 0031916435 scopus 로고    scopus 로고
    • Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
    • Schiedner G, Morral N, Parks RJ, Wu Y, Koopmans SC, Langston C, et al. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nat Genet 1998;18(2):180-183.
    • (1998) Nat Genet , vol.18 , Issue.2 , pp. 180-183
    • Schiedner, G.1    Morral, N.2    Parks, R.J.3    Wu, Y.4    Koopmans, S.C.5    Langston, C.6
  • 88
    • 0032506791 scopus 로고    scopus 로고
    • High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha-1 antitrypsin with negligible toxicity
    • Morral N, Parks RJ, Zhou H, Langston C, Schiedner G, Quinones J, et al. High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha-1 antitrypsin with negligible toxicity. Hum Gene Ther 1998;9(18):2709-2716.
    • (1998) Hum Gene Ther , vol.9 , Issue.18 , pp. 2709-2716
    • Morral, N.1    Parks, R.J.2    Zhou, H.3    Langston, C.4    Schiedner, G.5    Quinones, J.6
  • 89
    • 0347407815 scopus 로고    scopus 로고
    • Alpha-1 antitrypsin expression in the lung is increased by airway delivery of gene-transfected macrophages
    • Zhang D, Wu M, Nelson DE, Pasula R, Martin WJ II. Alpha-1 antitrypsin expression in the lung is increased by airway delivery of gene-transfected macrophages. Gene Ther 2003;10(26):2148-2152.
    • (2003) Gene Ther , vol.10 , Issue.26 , pp. 2148-2152
    • Zhang, D.1    Wu, M.2    Nelson, D.E.3    Pasula, R.4    Martin, W.J.5
  • 90
    • 0034193342 scopus 로고    scopus 로고
    • Transfection of nasal mucosa with a normal alpha-1 antitrypsin gene in alpha-1 antitrypsin-deficient subjects: Comparison with protein therapy
    • Brigham KL, Lane KB, Meyrick B, Stecenko AA, Strack S, Cannon DR, et al. Transfection of nasal mucosa with a normal alpha-1 antitrypsin gene in alpha-1 antitrypsin-deficient subjects: comparison with protein therapy. Hum Gene Ther 2000;11(7):1023-1032.
    • (2000) Hum Gene Ther , vol.11 , Issue.7 , pp. 1023-1032
    • Brigham, K.L.1    Lane, K.B.2    Meyrick, B.3    Stecenko, A.A.4    Strack, S.5    Cannon, D.R.6
  • 91
    • 60149095412 scopus 로고    scopus 로고
    • Gene transfer to the lung: Lessons learned from more than 2 decades of CF gene therapy
    • Griesenbach U, Alton EW. Gene transfer to the lung: lessons learned from more than 2 decades of CF gene therapy. Adv Drug Deliv Rev 2009;61(2):128-139.
    • (2009) Adv Drug Deliv Rev , vol.61 , Issue.2 , pp. 128-139
    • Griesenbach, U.1    Alton, E.W.2
  • 92
    • 10744227749 scopus 로고    scopus 로고
    • Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: A multicenter, double-blind, placebo-controlled trial
    • Moss RB, Rodman D, Spencer LT, Aitken ML, Zeitlin PL, Waltz D, et al. Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial. Chest 2004;125(2):509-521.
    • (2004) Chest , vol.125 , Issue.2 , pp. 509-521
    • Moss, R.B.1    Rodman, D.2    Spencer, L.T.3    Aitken, M.L.4    Zeitlin, P.L.5    Waltz, D.6
  • 93
    • 34548512049 scopus 로고    scopus 로고
    • Repeated aerosolized AAV-CFTR for treatment of cystic fibrosis: A randomized placebo-controlled phase 2B trial
    • Moss RB, Milla C, Colombo J, Accurso F, Zeitlin PL, Clancy JP, et al. Repeated aerosolized AAV-CFTR for treatment of cystic fibrosis: a randomized placebo-controlled phase 2B trial. Hum Gene Ther 2007;18(8):726-732.
    • (2007) Hum Gene Ther , vol.18 , Issue.8 , pp. 726-732
    • Moss, R.B.1    Milla, C.2    Colombo, J.3    Accurso, F.4    Zeitlin, P.L.5    Clancy, J.P.6
  • 94
    • 84885869516 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled phase IIB clinical trial of repeated application of gene therapy in patients with cystic fibrosis
    • Alton EW, Boyd AC, Cheng SH, Cunningham S, Davies JC, Gill DR, et al. A randomised, double-blind, placebo-controlled phase IIB clinical trial of repeated application of gene therapy in patients with cystic fibrosis. Thorax 2013;68(11):1075-1077.
    • (2013) Thorax , vol.68 , Issue.11 , pp. 1075-1077
    • Alton, E.W.1    Boyd, A.C.2    Cheng, S.H.3    Cunningham, S.4    Davies, J.C.5    Gill, D.R.6
  • 95
    • 84884802285 scopus 로고    scopus 로고
    • Moving forward: Cystic fibrosis gene therapy
    • Griesenbach U, Alton EW. Moving forward: cystic fibrosis gene therapy. Hum Mol Genet 2013;22(R1):R52-R58.
    • (2013) Hum Mol Genet , vol.22 , Issue.R1 , pp. R52-R58
    • Griesenbach, U.1    Alton, E.W.2
  • 96
    • 0036311444 scopus 로고    scopus 로고
    • New evidence for transmitter role of VIP in the airways: Impaired relaxation by a catalytic antibody
    • Berisha HI, Bratut M, Bangale Y, Colasurdo G, Paul S, Said SI. New evidence for transmitter role of VIP in the airways: impaired relaxation by a catalytic antibody. Pulm Pharmacol Ther 2002; 15(2):121-127.
    • (2002) Pulm Pharmacol Ther , vol.15 , Issue.2 , pp. 121-127
    • Berisha, H.I.1    Bratut, M.2    Bangale, Y.3    Colasurdo, G.4    Paul, S.5    Said, S.I.6
  • 98
    • 0035033922 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease
    • Delgado M, Abad C, Martinez C, Leceta J, Gomariz RP. Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease. Nat Med 2001;7(5):563-568.
    • (2001) Nat Med , vol.7 , Issue.5 , pp. 563-568
    • Delgado, M.1    Abad, C.2    Martinez, C.3    Leceta, J.4    Gomariz, R.P.5
  • 100
    • 0024564484 scopus 로고
    • Vasoactive intestinal polypeptide and asthma (Editorial)
    • Said SI. Vasoactive intestinal polypeptide and asthma (editorial). N Engl J Med 1989;320(19):1271-1273.
    • (1989) N Engl J Med , vol.320 , Issue.19 , pp. 1271-1273
    • Said, S.I.1
  • 101
    • 0028567676 scopus 로고
    • Low plasma concentrations of VIP and elevated levels of other neuropeptides during exacerbations of asthma
    • Cardell LO, Uddman R, Edvinsson L. Low plasma concentrations of VIP and elevated levels of other neuropeptides during exacerbations of asthma. Eur Respir J 1994;7(12):2169-2173.
    • (1994) Eur Respir J , vol.7 , Issue.12 , pp. 2169-2173
    • Cardell, L.O.1    Uddman, R.2    Edvinsson, L.3
  • 102
    • 0141576816 scopus 로고    scopus 로고
    • Nitric oxide and vasoactive intestinal peptide as co-transmitters of airway smooth-muscle relaxation: Analysis in neuronal nitric oxide synthase knockout mice
    • Hasaneen NA, Foda HD, Said SI. Nitric oxide and vasoactive intestinal peptide as co-transmitters of airway smooth-muscle relaxation: analysis in neuronal nitric oxide synthase knockout mice. Chest 2003;124(3):1067-1072.
    • (2003) Chest , vol.124 , Issue.3 , pp. 1067-1072
    • Hasaneen, N.A.1    Foda, H.D.2    Said, S.I.3
  • 103
    • 0037340061 scopus 로고    scopus 로고
    • Bronchodilation by an inhaled VPAC2 receptor agonist in patients with stable asthma
    • Lindén A, Hansson L, Andersson A, Palmqvist M, Arvidsson P, Löfdahl CG, et al. Bronchodilation by an inhaled VPAC2 receptor agonist in patients with stable asthma. Thorax 2003;58(3):217-221.
    • (2003) Thorax , vol.58 , Issue.3 , pp. 217-221
    • Lindén, A.1    Hansson, L.2    Ersson, A.3    Palmqvist, M.4    Arvidsson, P.5    Löfdahl, C.G.6
  • 105
    • 0034780321 scopus 로고    scopus 로고
    • Vasoactive intestinal polypeptide as mediator of asthma
    • Groneberg DA, Springer J, Fischer A. Vasoactive intestinal polypeptide as mediator of asthma. Pulm Pharmacol Ther 2001;14(5): 391-401.
    • (2001) Pulm Pharmacol Ther , vol.14 , Issue.5 , pp. 391-401
    • Groneberg, D.A.1    Springer, J.2    Fischer, A.3
  • 106
    • 56649122070 scopus 로고    scopus 로고
    • The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation
    • Said SI. The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation. Ann NY Acad Sci 2008;1144:148-153.
    • (2008) Ann NY Acad Sci , vol.1144 , pp. 148-153
    • Said, S.I.1
  • 107
    • 0038369941 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension
    • Petkov V, Mosgoeller W, Ziesche R, Raderer M, Stiebellehner L, Vonbank K, et al. Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension. J Clin Invest 2003; 111(9):1339-1346.
    • (2003) J Clin Invest , vol.111 , Issue.9 , pp. 1339-1346
    • Petkov, V.1    Mosgoeller, W.2    Ziesche, R.3    Raderer, M.4    Stiebellehner, L.5    Vonbank, K.6
  • 108
    • 0021732482 scopus 로고
    • Vasoactive intestinal peptide relaxes isolated strips of human bronchus, pulmonary artery, and lung parenchyma
    • Saga T, Said SI. Vasoactive intestinal peptide relaxes isolated strips of human bronchus, pulmonary artery, and lung parenchyma. Trans Assoc Am Physicians 1984;97:304-310.
    • (1984) Trans Assoc am Physicians , vol.97 , pp. 304-310
    • Saga, T.1    Said, S.I.2
  • 112
    • 0032779834 scopus 로고    scopus 로고
    • Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis
    • Roum JH, Borok Z, McElvaney NG, Grimes GJ, Bokser AD, Buhl R, Crystal RG. Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis. J Appl Physiol 1999;87(1):438-443.
    • (1999) J Appl Physiol , vol.87 , Issue.1 , pp. 438-443
    • Roum, J.H.1    Borok, Z.2    McElvaney, N.G.3    Grimes, G.J.4    Bokser, A.D.5    Buhl, R.6    Crystal, R.G.7
  • 114
    • 0030802906 scopus 로고    scopus 로고
    • Pulmonary oxidative stress response in young children with cystic fibrosis
    • Hull J, Vervaart P, Grimwood K, Phelan P. Pulmonary oxidative stress response in young children with cystic fibrosis. Thorax 1997; 52(6):557-560.
    • (1997) Thorax , vol.52 , Issue.6 , pp. 557-560
    • Hull, J.1    Vervaart, P.2    Grimwood, K.3    Phelan, P.4
  • 115
    • 13844322148 scopus 로고    scopus 로고
    • A pilot study of the effect of inhaled buffered reduced glutathione on the clinical status of patients with cystic fibrosis
    • Bishop C, Hudson VM, Hilton SC, Wilde C. A pilot study of the effect of inhaled buffered reduced glutathione on the clinical status of patients with cystic fibrosis. Chest 2005;127(1):308-317.
    • (2005) Chest , vol.127 , Issue.1 , pp. 308-317
    • Bishop, C.1    Hudson, V.M.2    Hilton, S.C.3    Wilde, C.4
  • 116
    • 51549090573 scopus 로고    scopus 로고
    • Improvement in clinical markers in CF patients using a reduced glutathione regimen: An uncontrolled, observational study
    • Visca A, Bishop CT, Hilton SC, Hudson VM. Improvement in clinical markers in CF patients using a reduced glutathione regimen: an uncontrolled, observational study. J Cyst Fibros 2008;7(5): 433-436.
    • (2008) J Cyst Fibros , vol.7 , Issue.5 , pp. 433-436
    • Visca, A.1    Bishop, C.T.2    Hilton, S.C.3    Hudson, V.M.4
  • 117
    • 84880170145 scopus 로고    scopus 로고
    • Inhalation treatment with glutathione in patients with cystic fibrosis. A randomized clinical trial
    • Griese M, Kappler M, Eismann C, Ballmann M, Junge S, Rietschel E, et al. Inhalation treatment with glutathione in patients with cystic fibrosis. A randomized clinical trial. Am J Respir Crit Care Med 2013;188(1):83-89.
    • (2013) Am J Respir Crit Care Med , vol.188 , Issue.1 , pp. 83-89
    • Griese, M.1    Kappler, M.2    Eismann, C.3    Ballmann, M.4    Junge, S.5    Rietschel, E.6
  • 119
    • 0033588819 scopus 로고    scopus 로고
    • Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/ macrophage colony-stimulating factor
    • Kitamura T, Tanaka N, Watanabe J, Uchida, Kanegasaki S, Yamada Y, Nakata K. Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/ macrophage colony-stimulating factor. J Exp Med 1999;190(6): 875-880.
    • (1999) J Exp Med , vol.190 , Issue.6 , pp. 875-880
    • Kitamura, T.1    Tanaka, N.2    Watanabe, J.3    Uchida, K.S.4    Yamada, Y.5    Nakata, K.6
  • 121
    • 0036787956 scopus 로고    scopus 로고
    • Autoantibodies against granulocyte macrophage colonystimulating factor are diagnostic for pulmonary alveolar proteinosis
    • Bonfield TL, Russell D, Burgess S, Malur A, Kavuru MS, Thomassen MJ. Autoantibodies against granulocyte macrophage colonystimulating factor are diagnostic for pulmonary alveolar proteinosis. Am J Respir Cell Mol Biol 2002;27(4):481-486.
    • (2002) Am J Respir Cell Mol Biol , vol.27 , Issue.4 , pp. 481-486
    • Bonfield, T.L.1    Russell, D.2    Burgess, S.3    Malur, A.4    Kavuru, M.S.5    Thomassen, M.J.6
  • 122
    • 9144247674 scopus 로고    scopus 로고
    • High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis
    • Uchida K, Nakata K, Trapnell BC, Terakawa T, Hamano E, Mikami A, et al. High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. Blood 2004;103(3):1089-1098.
    • (2004) Blood , vol.103 , Issue.3 , pp. 1089-1098
    • Uchida, K.1    Nakata, K.2    Trapnell, B.C.3    Terakawa, T.4    Hamano, E.5    Mikami, A.6
  • 123
    • 0032954397 scopus 로고    scopus 로고
    • Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice
    • Reed JA, Ikegami M, Cianciolo ER, Lu W, Cho PS, Hull W, et al. Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice. Am J Physiol 1999;276(4 Pt 1):L556–L563.
    • (1999) Am J Physiol , vol.276 , Issue.4 , pp. L556-L563
    • Reed, J.A.1    Ikegami, M.2    Cianciolo, E.R.3    Lu, W.4    Cho, P.S.5    Hull, W.6
  • 124
    • 20844435308 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor and lung immunity in pulmonary alveolar proteinosis
    • Tazawa R, Hamano E, Arai T, Ohta H, Ishimoto O, Uchida K, et al. Granulocyte-macrophage colony-stimulating factor and lung immunity in pulmonary alveolar proteinosis. Am J Respir Crit Care Med 2005;171(10):1142-1149.
    • (2005) Am J Respir Crit Care Med , vol.171 , Issue.10 , pp. 1142-1149
    • Tazawa, R.1    Hamano, E.2    Arai, T.3    Ohta, H.4    Ishimoto, O.5    Uchida, K.6
  • 125
    • 77950628896 scopus 로고    scopus 로고
    • Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis
    • Tazawa R, Trapnell BC, Inoue Y, Arai T, Takada T, Nasuhara Y, et al. Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis. Am J Respir Crit Care Med 2010;181(12):1345-1354.
    • (2010) Am J Respir Crit Care Med , vol.181 , Issue.12 , pp. 1345-1354
    • Tazawa, R.1    Trapnell, B.C.2    Inoue, Y.3    Arai, T.4    Takada, T.5    Nasuhara, Y.6
  • 126
    • 33644850551 scopus 로고    scopus 로고
    • Aerosol granulocyte-macrophage colony-stimulating factor for pulmonary alveolar proteinosis
    • Wylam ME, Ten R, Prakash UB, Nadrous HF, Clawson ML, Anderson PM. Aerosol granulocyte-macrophage colony-stimulating factor for pulmonary alveolar proteinosis. Eur Respir J 2006;27(3):585-593.
    • (2006) Eur Respir J , vol.27 , Issue.3 , pp. 585-593
    • Wylam, M.E.1    Ten, R.2    Prakash, U.B.3    Nadrous, H.F.4    Clawson, M.L.5    Erson, P.M.6
  • 127
    • 79251594597 scopus 로고    scopus 로고
    • Physical properties, lung deposition modeling, and bioactivity of recombinant GM-CSF aerosolised with a highly efficient nebulizer
    • Luisetti M, Kroneberg P, Suzuki T, Kadija Z, Muellinger B, Campo I, et al. Physical properties, lung deposition modeling, and bioactivity of recombinant GM-CSF aerosolised with a highly efficient nebulizer. Pulm Pharmacol Ther 2011;24(1):123-127.
    • (2011) Pulm Pharmacol Ther , vol.24 , Issue.1 , pp. 123-127
    • Luisetti, M.1    Kroneberg, P.2    Suzuki, T.3    Kadija, Z.4    Muellinger, B.5    Campo, I.6
  • 128
    • 0033829969 scopus 로고    scopus 로고
    • A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: The prevent recurrence of osteoporotic fractures study
    • Chestnut CH 3rd, Silverman S, Andriano K, Genant H, Gimona A, Harris S, et al. A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the prevent recurrence of osteoporotic fractures study. Am J Med 2000; 109(4):267-276.
    • (2000) Am J Med , vol.109 , Issue.4 , pp. 267-276
    • Chestnut, C.H.1    Silverman, S.2    Riano, K.3    Genant, H.4    Gimona, A.5    Harris, S.6
  • 130
    • 84907573731 scopus 로고    scopus 로고
    • 5th edition, Accessed Aug 26, 2013
    • International Diabetes Federation. IDF Diabetes Atlas, 5th edition. http://www.idf.org/diabetesatlas/5e/the-global-burden. Accessed Aug 26, 2013.
    • IDF Diabetes Atlas
  • 131
    • 84888378135 scopus 로고    scopus 로고
    • Further experimentation of inhaled LANTUS, ACTRAPID and HUMULIN with todays’ production systems
    • Zarogoulidis P, Petridis D, Ritzoulis C, Li Q, Huang H, Ning Y, et al. Further experimentation of inhaled LANTUS, ACTRAPID and HUMULIN with todays’ production systems. Int J Pharm 2013; 458(1):39-47.
    • (2013) Int J Pharm , vol.458 , Issue.1 , pp. 39-47
    • Zarogoulidis, P.1    Petridis, D.2    Ritzoulis, C.3    Li, Q.4    Huang, H.5    Ning, Y.6
  • 133
    • 34250704756 scopus 로고    scopus 로고
    • Clinical research observations with use of Exubera in patients with type 1 and type 2 diabetes
    • Cefalu WT, Wang ZQ. Clinical research observations with use of Exubera in patients with type 1 and type 2 diabetes. Diabetes Technol Ther 2007;9(Suppl 1):S28-S40.
    • (2007) Diabetes Technol Ther , vol.9 , pp. S28-S40
    • Cefalu, W.T.1    Wang, Z.Q.2
  • 134
    • 34250719693 scopus 로고    scopus 로고
    • Delivering needle-free insulin using the AERx IDMS (Insulin diabetes management system) technology
    • Wollmer P, Pieber TR, Gall MA, Brunton S. Delivering needle-free insulin using the AERx IDMS (insulin diabetes management system) technology. Diabetes Technol Ther 2007;9(Suppl 1):S57-S64.
    • (2007) Diabetes Technol Ther , vol.9 , pp. S57-S64
    • Wollmer, P.1    Pieber, T.R.2    Gall, M.A.3    Brunton, S.4
  • 135
    • 34250724881 scopus 로고    scopus 로고
    • The AIR inhaled insulin system: System components and pharmacokinetic/ glucodynamic data
    • Muchmore DB, Silverman B, De La Peña A, Tobian J. The AIR inhaled insulin system: system components and pharmacokinetic/ glucodynamic data. Diabetes Technol Ther 2007;9(Suppl 1):S41-S47.
    • (2007) Diabetes Technol Ther , vol.9 , pp. S41-S47
    • Muchmore, D.B.1    Silverman, B.2    De La Peña, A.3    Tobian, J.4
  • 136
    • 34250763713 scopus 로고    scopus 로고
    • Review of phase 2 studies utilizing the AIR particle technology in the delivery of human insulin inhalation powder versus subcutaneous regular or lispro insulin in subjects with type 1 or type 2 diabetes
    • Ellis SL, Gemperline KA, Garg S. Review of phase 2 studies utilizing the AIR particle technology in the delivery of human insulin inhalation powder versus subcutaneous regular or lispro insulin in subjects with type 1 or type 2 diabetes. Diabetes Technol Ther 2007;9(Suppl 1):S48-S56.
    • (2007) Diabetes Technol Ther , vol.9 , pp. S48-S56
    • Ellis, S.L.1    Gemperline, K.A.2    Garg, S.3
  • 137
    • 84928818205 scopus 로고    scopus 로고
    • The expanding role of aerosol in systemic drug delivery, gene therapy and vaccination: An update
    • Laube BL. The expanding role of aerosol in systemic drug delivery, gene therapy and vaccination: an update. Transl Respir Med 2014; 2:3.
    • (2014) Transl Respir Med , vol.2 , pp. 3
    • Laube, B.L.1
  • 138
    • 59249104634 scopus 로고    scopus 로고
    • Efficacy and safety of Technosphere inhaled insulin compared with Technosphere powder placebo in insulin-naive type 2 diabetes suboptimally controlled with oral agents
    • Rosenstock J, Bergenstal R, DeFronzo RA, Hirsch IB, Klonoff D, Boss AH, et al. Efficacy and safety of Technosphere inhaled insulin compared with Technosphere powder placebo in insulin-naive type 2 diabetes suboptimally controlled with oral agents. Diabetes Care 2008;31(11):2177-2182.
    • (2008) Diabetes Care , vol.31 , Issue.11 , pp. 2177-2182
    • Rosenstock, J.1    Bergenstal, R.2    Defronzo, R.A.3    Hirsch, I.B.4    Klonoff, D.5    Boss, A.H.6
  • 139
    • 77953839066 scopus 로고    scopus 로고
    • Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for type 2 diabetes: A multicentre randomised trial
    • Rosenstock J, Lorber DL, Gnudi L, Howard CP, Bilheimer DW, Chang PC, et al. Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for type 2 diabetes: a multicentre randomised trial. Lancet 2010;375(9733):2244-2253.
    • (2010) Lancet , vol.375 , Issue.9733 , pp. 2244-2253
    • Rosenstock, J.1    Lorber, D.L.2    Gnudi, L.3    Howard, C.P.4    Bilheimer, D.W.5    Chang, P.C.6
  • 141
    • 84893290893 scopus 로고    scopus 로고
    • Medicon Valley Inhalation Symposium, 16 October 2013, Lund, Sweden
    • Lastow O. 2nd Medicon Valley Inhalation Symposium, 16 October 2013, Lund, Sweden. Ther Deliv 2014;5(2):119-121.
    • (2014) Ther Deliv , vol.5 , Issue.2 , pp. 119-121
    • Lastow, O.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.