Cyclosporin A Aerosol Improves the Anticancer Effect of Paclitaxel Aerosol in Mice

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 17, Issue 1, 2004, Pages 7-14

  Koshkina, Nadezhda V ^a   Golunski, Eva ^a   Roberts, Luz E ^a   Gilbert, Brian E ^a   Knight, Vernon ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Adjuvant chemotherapy; Jet nebulizer; Liposome; Lung cancer; Toxicity

Indexed keywords

CYCLOSPORIN A; LIPOSOME; PACLITAXEL;

AEROSOL; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENTIATION; DRUG SCREENING; FEMALE; INTERMETHOD COMPARISON; KIDNEY CARCINOMA; LUNG WEIGHT; MOUSE; NONHUMAN; STATISTICAL SIGNIFICANCE; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, RENAL CELL; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; KIDNEY NEOPLASMS; LIPOSOMES; LUNG NEOPLASMS; MICE; PACLITAXEL;

EID: 1942533024     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/089426804322994415     Document Type: Article

References (33)

1. Koshkina, N.V., E.S. Kleinerman, J.D. Waldrep, et al. 2000. 9-Nitrocamptothecin liposome aerosol treatment of melanoma and osteosarcoma lung metastases in mice. Clin. Cancer Res. 6:2876-2880.
2. Koshkina, N.V., J.C. Waldrep, L. Roberts, et al. 2001. Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model. Clin. Cancer Res. 7:3258-3262.
3. Gilbert, B.E., C. Knight, F.G. Alvarez, et al. 1997. Tolerance of volunteers to cyclosporine A - dilauroylphosphatidylcholine liposome aerosol. Am. J. Respir. Crit. Care Med. 156:1789-1793.
4. Knight, V., N.V. Koshkina, J.C. Waldrep, et al. 1999. Anticancer effect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice. Cancer Chemother. Pharmacol. 44:1771-1786.
5. Verschraegen, C.F., B.E. Gilbert, A.J. Huaringa, et al. 2000. Feasibility, phase I, and pharmacological study of aerosolized liposomal 9-nitro-20(S)-camptothecin in patients with advanced malignancies in the lungs. Ann. N.Y. Acad. Sci. 922:352-354.
6. Rowinsky, E.K., and R.C. Donehower. 1995. Paclitaxel (taxol). N. Engl. J. Med. 332:1004-1014.
7. Weiss, R.B., R.C. Donehower, P.H. Wiernik, et al. 1990. Hypersensitivity reactions from taxol. J. Clin. Oncol. 8:1263-1268.
8. Sharma, A., E. Mayhew, L. Bolcsak, et al. 1997. Activity of paclitaxel liposome formulations against human ovarian tumor xenografts. Int. J. Cancer 71: 103-107.
9. Cabanes, A., K.E. Briggs, P.C., Cokhale, et al. 1998. Comparative in vivo studies with paclitaxel and liposome-encapsulated paclitaxel. Int. J. Oncol. 12: 1035-1040.
10. Ross, H.J., A.L. Canada, and L.M. Slater. 1997. Cyclosporin A enhances paclitaxel toxicity against leukemia and respiratory epithelial cancers. Clin. Cancer Res. 3:57-62.
11. Sood, A.K., J.I. Sorosky, R.C. Squatrito, et al. 1999. Cyclosporin A reverses chemoresistance in patients with gynecologic malignancies. Neoplasia 1:118-122.
12. Sonnichsen, D.S., Q. Liu, E.G. Scheutz, et al. 1995. Variability in human cytochrome P450 paclitaxel metabolism. J. Pharmacol. Exp. Ther. 275:566-575.
13. Fujitaka, K., T. Oguri, T. Isobe, et al. 2001. Induction of cytochrome P450 3A4 by docetaxel in peripheral mononuclear cells and its expression in lung cancer. Cancer Chemother. Pharmacol. 48:42-46.
14. Younes, E., G.P. Haas, B. Dezso, et al. 1995. Local tumor irradiation augments the response to IL-2 therapy in a murine renal adenocarcinoma. Cell Immunol. 165:243-251.
15. 2-enriched air: pharmacokinetic studies. Cancer Chemother. Pharmacol. 47:451-456.
16. Fairchild, G.A. 1972. Measurement of respiratory volume for virus retention studies in mice. Appl. Microbiol. 24:812-818.
17. Phalen, R. 1972. Inhalation Studies: Foundations and Techniques. CRC Press, Boca Raton, FL.
18. Schieff, P.B., and S.B. Horwitz. 1980. Taxol stabilizes microtubules in mouse fibroblast cells. Proc. Natl. Acad. Sci. USA 77:1561-1565.
19. Sakai, H., S. Yoneda, T. Tamura, et al. 2001. A phase II study of paclitaxel plus cisplatin for advanced nonsmall-cell lung cancer in Japanese patients. Cancer Chemother. Pharmacol. 48:499-503.
20. Kosmas, C., N. Tsavaris, M. Vadiaka, et al. 2001. Gemcitabine and docetaxel as second-line chemotherapy for patients with nonsmall cell lung carcinoma who fail prior paclitaxel plus platinum-based regimens. Cancer 92:2902-2910.
21. Choy, H., and R. MacRae. 2001. The current state of paclitaxel and radiation in the combined-modality therapy of non-small cell lung cancer. Semin. Oncol. 28(Suppl 14):17-22.
22. Meerum-Terwogt, J.M., M.M. Malingre, J.H. Beijnen, et al. 1999. Coadministration of oral cyclosporin A enables oral therapy with paclitaxel. Clin. Cancer Res. 5:3379-3384.
23. Sikic, B.I., G.A. Fisher, B.L. Lum, et al. 1997. Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein. Cancer Chemother. Pharmacol. 40(Suppl):S13-19.
24. Germann, U.A. 2000. Detection of recombinant P-glycoprotein in multidrug resistant cultured cells. Mol. Biotechnol. 14:131-145.
25. Gottesman, M.M., and L. Pastan. 1993. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:385-427.
26. Wandel, C., R.B. Kim, S. Kajiji, et al. 1999. P-glycoprotein and cytochrome P450 3A inhibition: dissociation of inhibitory potencies. Cancer Res. 59:3944-3948.
27. Cresteil, T., B. Monsarrat, P. Alvinerie, et al. 1994. Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation. Cancer Res. 54:386-392.
28. Sugawara, I., S. Akiyama, R.J. Scheper, et al. 1997. Lung resistance protein (LRP) - expression in human normal tissues in comparison with that of MDR1 and MRP. Cancer Lett. 112:23-31.
29. Yokoyama, H., T. Ishida, K. Sugio, et al. 1999. Immunohistochemical evidence that P-glycoprotein in non-small cell lung cancers is associated with shorter survival. Surg. Today 29:1141-1147.
30. Remuzzi, G., and Perico, N. 1995. Cyclosporine-induced renal dysfunction in experimental animals and humans. Kidney Int. Suppl. 52:S70-74.
31. Gilbert, B.E., M. Black, J.C. Waldrep, et al. 1997. Cyclosporin A liposome aerosol: lack of toxicity in rats. Inhal. Toxicol. 9:717-730.
32. Hsieh, T.H., C.P. Yu, and G. Oberdorster. 1999. Deposition and clearance models of Ni compounds in the mouse lung and comparisons with the rat models. Aerosol Sci. Technol. 31:358-372.
33. Koshkina, N.V., B.E. Gilbert, J.C. Waldrep, et al. 1999. Distribution of camptothecin after delivery as a liposome aerosol or following intramuscular administration in mice. Cancer Chemother. Pharmacol. 44:187-192.