Reducing ribosomal protein S6 kinase 1 expression improves spatial memory and synaptic plasticity in a mouse model of Alzheimer’s disease

Journal of Neuroscience

Volumn 35, Issue 41, 2015, Pages 14042-14056

  Caccamo, Antonella ^a,b   Branca, Caterina ^a,d   Talboom, Joshua S ^a   Shaw, Darren M ^a   Turner, Dharshaun ^c   Ma, Luyao ^c   Messina, Angela ^b   Huang, Zebing ^c,e   Wu, Jie ^c,d   Oddo, Salvatore ^a,d  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CATANIA   (Italy)

^c BARROW NEUROLOGICAL INSTITUTE   (United States)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^e CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

AD; Aging; A ; mTOR; Plaques; Tangles

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE; PROTEASOME; S6 KINASE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; PEPTIDE FRAGMENT; PRESENILIN 1; PSEN1 PROTEIN, HUMAN; RPS6KA1 PROTEIN, MOUSE; SECRETASE; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN HOMOGENATE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; LEARNING; MALE; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; POLYSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SPATIAL MEMORY; UPREGULATION; ANIMAL; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HIPPOCAMPUS; LOCOMOTION; LONG TERM POTENTIATION; MAZE TEST; MEMORY DISORDERS; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; LOCOMOTION; LONG-TERM POTENTIATION; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; NEURONAL PLASTICITY; NEURONS; PEPTIDE FRAGMENTS; PRESENILIN-1; PROTEASOME ENDOPEPTIDASE COMPLEX; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIGNAL TRANSDUCTION; TAU PROTEINS;

EID: 84944546315     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2781-15.2015     Document Type: Article

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