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Volumn 526, Issue 7573, 2015, Pages 343-350

Pharmacogenomics in the clinic

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; HLA B ANTIGEN;

EID: 84944311937     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature15817     Document Type: Review
Times cited : (613)

References (112)
  • 1
    • 84937523283 scopus 로고    scopus 로고
    • Evolutionary consequences of drug resistance: Shared principles across diverse targets and organisms
    • Hughes, D. & Andersson, D. I. Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms. Nature Rev. Genet. 16, 459-471 (2015).
    • (2015) Nature Rev. Genet. , vol.16 , pp. 459-471
    • Hughes, D.1    Andersson, D.I.2
  • 2
    • 2642570170 scopus 로고    scopus 로고
    • Moving towards individualized medicine with pharmacogenomics
    • Evans, W. E. & Relling, M. V. Moving towards individualized medicine with pharmacogenomics. Nature 429, 464-468 (2004).
    • (2004) Nature , vol.429 , pp. 464-468
    • Evans, W.E.1    Relling, M.V.2
  • 3
    • 0000616920 scopus 로고
    • Enzymatic deficiency in primaquine-sensitive erythrocytes
    • Alving, A. S., Carson, P. E., Flanagan, C. L. & Ickes, C. E. Enzymatic deficiency in primaquine-sensitive erythrocytes. Science 124, 484-485 (1956).
    • (1956) Science , vol.124 , pp. 484-485
    • Alving, A.S.1    Carson, P.E.2    Flanagan, C.L.3    Ickes, C.E.4
  • 4
    • 0002459750 scopus 로고
    • The crucial experiment of Wilhelm Johannsen
    • Roll-Hansen, N. The crucial experiment of Wilhelm Johannsen. Biol. Phil. 4, 303-329 (1989).
    • (1989) Biol. Phil. , vol.4 , pp. 303-329
    • Roll-Hansen, N.1
  • 5
    • 70449136457 scopus 로고
    • Drug reactions enzymes, and biochemical genetics
    • Motulsky, A. G. Drug reactions enzymes, and biochemical genetics. J. Am. Med. Assoc. 165, 835-837 (1957).
    • (1957) J. Am. Med. Assoc. , vol.165 , pp. 835-837
    • Motulsky, A.G.1
  • 6
    • 70449162191 scopus 로고
    • A method for the detection of atypical forms of human serum cholinesterase; Determination of dibucaine numbers
    • Kalow, W. & Genest, K. A method for the detection of atypical forms of human serum cholinesterase; determination of dibucaine numbers. Can. J. Biochem. Physiol. 35, 339-346 (1957).
    • (1957) Can. J. Biochem. Physiol. , vol.35 , pp. 339-346
    • Kalow, W.1    Genest, K.2
  • 7
    • 0002150481 scopus 로고
    • Moderne problem der humangenetik
    • Vogel, F. Moderne problem der humangenetik. Ergeb. Inn. Med. U. Kinderheik. 12, 52-125 (1959).
    • (1959) Ergeb. Inn. Med. U. Kinderheik. , vol.12 , pp. 52-125
    • Vogel, F.1
  • 8
    • 0014403645 scopus 로고
    • Genetic control of drug levels in man: Antipyrine
    • Vesell, E. S. & Page, J. G. Genetic control of drug levels in man: antipyrine. Science 161, 72-73 (1968).
    • (1968) Science , vol.161 , pp. 72-73
    • Vesell, E.S.1    Page, J.G.2
  • 9
    • 0006948626 scopus 로고
    • Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis
    • Hughes, H. B., Biehl, J. P., Jones, A. P. & Schmidt, L. H. Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis. Am. Rev. Tuberc. 70, 266-273 (1954).
    • (1954) Am. Rev. Tuberc. , vol.70 , pp. 266-273
    • Hughes, H.B.1    Biehl, J.P.2    Jones, A.P.3    Schmidt, L.H.4
  • 10
    • 26444539817 scopus 로고
    • Genetic control of isoniazid metabolism in man
    • Price Evans, D. A., Manley, K. A. & McKusick, V. A. Genetic control of isoniazid metabolism in man. Br. Med. J. 2, 485-491 (1960).
    • (1960) Br. Med. J. , vol.2 , pp. 485-491
    • Price Evans, D.A.1    Manley, K.A.2    McKusick, V.A.3
  • 11
    • 0025948280 scopus 로고
    • Molecular mechanism of slow acetylation of drugs and carcinogens in humans
    • Blum, M., Demierre, A., Grant, D. M., Heim, M. & Meyer, U. A. Molecular mechanism of slow acetylation of drugs and carcinogens in humans. Proc. Natl Acad. Sci. USA 88, 5237-5241 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 5237-5241
    • Blum, M.1    Demierre, A.2    Grant, D.M.3    Heim, M.4    Meyer, U.A.5
  • 12
    • 0025917067 scopus 로고
    • Diverse point mutations in the human gene for polymorphic N-acetyltransferase
    • Vatsis, K. P., Martell, K. J. & Weber, W. W. Diverse point mutations in the human gene for polymorphic N-acetyltransferase. Proc. Natl Acad. Sci. USA 88, 6333-6337 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 6333-6337
    • Vatsis, K.P.1    Martell, K.J.2    Weber, W.W.3
  • 13
    • 0023854270 scopus 로고
    • Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
    • Gonzalez, F. J. et al. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 331, 442-446 (1988).
    • (1988) Nature , vol.331 , pp. 442-446
    • Gonzalez, F.J.1
  • 14
    • 38949188630 scopus 로고    scopus 로고
    • Pharmacogenomic biomarkers for prediction of severe adverse drug reactions
    • Ingelman-Sundberg, M. Pharmacogenomic biomarkers for prediction of severe adverse drug reactions. N. Engl. J. Med. 358, 637-639 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 637-639
    • Ingelman-Sundberg, M.1
  • 16
    • 0030934850 scopus 로고    scopus 로고
    • Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance
    • Yates, C. R. et al. Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance. Ann. Intern. Med. 126, 608-614 (1997).
    • (1997) Ann. Intern. Med. , vol.126 , pp. 608-614
    • Yates, C.R.1
  • 17
    • 0142240380 scopus 로고    scopus 로고
    • Preventing toxicity with a gene test
    • Marshall, E. Preventing toxicity with a gene test. Science 302, 588-590 (2003).
    • (2003) Science , vol.302 , pp. 588-590
    • Marshall, E.1
  • 18
    • 84902282939 scopus 로고    scopus 로고
    • Pharmacogenomics: Current state-of-the-art
    • Carr, D. F., Alfirevic, A. & Pirmohamed, M. Pharmacogenomics: Current state-of-the-art. Genes (Basel) 5, 430-443 (2014).
    • (2014) Genes (Basel) , vol.5 , pp. 430-443
    • Carr, D.F.1    Alfirevic, A.2    Pirmohamed, M.3
  • 19
    • 84924077585 scopus 로고    scopus 로고
    • Oral anticoagulation: A critique of recent advances and controversies
    • Pirmohamed, M., Kamali, F., Daly, A. K. & Wadelius, M. Oral anticoagulation: a critique of recent advances and controversies. Trends Pharmacol. Sci. 36, 153-163 (2015).
    • (2015) Trends Pharmacol. Sci. , vol.36 , pp. 153-163
    • Pirmohamed, M.1    Kamali, F.2    Daly, A.K.3    Wadelius, M.4
  • 21
    • 84886690638 scopus 로고    scopus 로고
    • Complexities of CYP2D6 gene analysis and interpretation
    • Gaedigk, A. Complexities of CYP2D6 gene analysis and interpretation. Int. Rev. Psychiatry 25, 534-553 (2013).
    • (2013) Int. Rev. Psychiatry , vol.25 , pp. 534-553
    • Gaedigk, A.1
  • 22
    • 33747878216 scopus 로고    scopus 로고
    • What is the clinical utility of genetic testing?
    • Grosse, S. D. & Khoury, M. J. What is the clinical utility of genetic testing? Genet. Med. 8, 448-450 (2006).
    • (2006) Genet. Med. , vol.8 , pp. 448-450
    • Grosse, S.D.1    Khoury, M.J.2
  • 23
    • 82955233708 scopus 로고    scopus 로고
    • Personalizing medicine with clinical pharmacogenetics
    • Scott, S. A. Personalizing medicine with clinical pharmacogenetics. Genet. Med. 13, 987-995 (2011).
    • (2011) Genet. Med. , vol.13 , pp. 987-995
    • Scott, S.A.1
  • 24
    • 84922479874 scopus 로고    scopus 로고
    • Effects of a HLA-B∗15:02 screening policy on antiepileptic drug use and severe skin reactions
    • Chen, Z., Liew, D. & Kwan, P. Effects of a HLA-B∗15:02 screening policy on antiepileptic drug use and severe skin reactions. Neurology 83, 2077-2084 (2014).
    • (2014) Neurology , vol.83 , pp. 2077-2084
    • Chen, Z.1    Liew, D.2    Kwan, P.3
  • 25
    • 79951809825 scopus 로고    scopus 로고
    • CPIC: Clinical pharmacogenetics implementation consortium of the pharmacogenomics research network
    • Relling, M. V. & Klein, T. E. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network. Clin. Pharmacol. Ther. 89, 464-467 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 464-467
    • Relling, M.V.1    Klein, T.E.2
  • 26
    • 84900854522 scopus 로고    scopus 로고
    • Incorporation of pharmacogenomics into routine clinical practice: The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process
    • Caudle, K. E. et al. Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process. Curr. Drug Metab. 15, 209-217 (2014).
    • (2014) Curr. Drug Metab. , vol.15 , pp. 209-217
    • Caudle, K.E.1
  • 27
    • 84897022750 scopus 로고    scopus 로고
    • Clinical pharmacogenetics implementation consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update
    • Crews, K. R. et al. Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin. Pharmacol. Ther. 95, 376-382 (2014).
    • (2014) Clin. Pharmacol. Ther. , vol.95 , pp. 376-382
    • Crews, K.R.1
  • 28
    • 38949196447 scopus 로고    scopus 로고
    • HLA-B∗5701 screening for hypersensitivity to abacavir
    • Mallal, S. et al. HLA-B∗5701 screening for hypersensitivity to abacavir. N. Engl. J. Med. 358, 568-579 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 568-579
    • Mallal, S.1
  • 29
    • 84899417586 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and abacavir dosing: 2014 update
    • Martin, M. A. et al. Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and abacavir dosing: 2014 update. Clin. Pharmacol. Ther. 95, 499-500 (2014).
    • (2014) Clin. Pharmacol. Ther. , vol.95 , pp. 499-500
    • Martin, M.A.1
  • 30
    • 84904807062 scopus 로고    scopus 로고
    • Interpreting the CYP2D6 results from the International Tamoxifen Pharmacogenetics Consortium
    • Province, M. A., Altman, R. B. & Klein, T. E. Interpreting the CYP2D6 results from the International Tamoxifen Pharmacogenetics Consortium. Clin. Pharmacol. Ther. 96, 144-146 (2014).
    • (2014) Clin. Pharmacol. Ther. , vol.96 , pp. 144-146
    • Province, M.A.1    Altman, R.B.2    Klein, T.E.3
  • 31
    • 84880758064 scopus 로고    scopus 로고
    • CYP2D6 genotype and tamoxifen activity: Understanding interstudy variability in methodological quality
    • Ratain, M. J., Nakamura, Y. & Cox, N. J. CYP2D6 genotype and tamoxifen activity: understanding interstudy variability in methodological quality. Clin. Pharmacol. Ther. 94, 185-187 (2013).
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 185-187
    • Ratain, M.J.1    Nakamura, Y.2    Cox, N.J.3
  • 32
    • 84872587241 scopus 로고    scopus 로고
    • Tamoxifen use in postmenopausal breast cancer: CYP2D6 matters
    • Brauch, H. et al. Tamoxifen use in postmenopausal breast cancer: CYP2D6 matters. J. Clin. Oncol. 31, 176-180 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 176-180
    • Brauch, H.1
  • 33
    • 80052020634 scopus 로고    scopus 로고
    • Genotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: A multicenter study
    • Irvin, W. J. Jr et al. Genotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: a multicenter study. J. Clin. Oncol. 29, 3232-3239 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3232-3239
    • Irvin, W.J.1
  • 34
    • 84897861518 scopus 로고    scopus 로고
    • Prediction of tamoxifen outcome by genetic variation of CYP2D6 in post-menopausal women with early breast cancer
    • Brauch, H. & Schwab, M. Prediction of tamoxifen outcome by genetic variation of CYP2D6 in post-menopausal women with early breast cancer. Br. J. Clin. Pharmacol. 77, 695-703 (2014).
    • (2014) Br. J. Clin. Pharmacol. , vol.77 , pp. 695-703
    • Brauch, H.1    Schwab, M.2
  • 35
    • 84893732936 scopus 로고    scopus 로고
    • CYP2D6 genotype and adjuvant tamoxifen: Meta-analysis of heterogeneous study populations
    • Province, M. A. et al. CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations. Clin. Pharmacol. Ther. 95, 216-227 (2014).
    • (2014) Clin. Pharmacol. Ther. , vol.95 , pp. 216-227
    • Province, M.A.1
  • 36
    • 84929948534 scopus 로고    scopus 로고
    • Pharmacogenomic information in drug labels: European Medicines Agency perspective
    • Ehmann, F. et al. Pharmacogenomic information in drug labels: European Medicines Agency perspective. Pharmacogenomics J. 15, 201-210 (2015).
    • (2015) Pharmacogenomics J. , vol.15 , pp. 201-210
    • Ehmann, F.1
  • 37
    • 84894468169 scopus 로고    scopus 로고
    • Pharmacogenomic biomarkers in drug labels: What do they tell us?
    • Tutton, R. Pharmacogenomic biomarkers in drug labels: what do they tell us? Pharmacogenomics 15, 297-304 (2014).
    • (2014) Pharmacogenomics , vol.15 , pp. 297-304
    • Tutton, R.1
  • 38
    • 84880907387 scopus 로고    scopus 로고
    • Characteristics of pharmacogenomics/biomarker-guided clinical trials for regulatory approval of anti-cancer drugs in Japan
    • Ishiguro, A., Yagi, S. & Uyama, Y. Characteristics of pharmacogenomics/biomarker-guided clinical trials for regulatory approval of anti-cancer drugs in Japan. J. Hum. Genet. 58, 313-316 (2013).
    • (2013) J. Hum. Genet. , vol.58 , pp. 313-316
    • Ishiguro, A.1    Yagi, S.2    Uyama, Y.3
  • 39
    • 0028867826 scopus 로고
    • The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome
    • Bosma, P. J. et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N. Engl. J. Med. 333, 1171-1175 (1995).
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1171-1175
    • Bosma, P.J.1
  • 40
    • 0027940492 scopus 로고
    • G6PD deficiency
    • Beutler, E. G6PD deficiency. Blood 84, 3613-3636 (1994).
    • (1994) Blood , vol.84 , pp. 3613-3636
    • Beutler, E.1
  • 41
    • 84880557325 scopus 로고    scopus 로고
    • Genomic medicine: A decade of successes, challenges, and opportunities
    • McCarthy J. J., McLeod, H. L. & Ginsburg, G. S. Genomic medicine: a decade of successes, challenges, and opportunities. Sci. Transl. Med. 5, 189sr4 (2013).
    • (2013) Sci. Transl. Med. , vol.5 , pp. 189sr4
    • McCarthy, J.J.1    McLeod, H.L.2    Ginsburg, G.S.3
  • 42
    • 84906303552 scopus 로고    scopus 로고
    • An overview of FDA-approved new molecular entities: 1827-2013
    • Kinch, M. S., Haynesworth, A., Kinch, S. L. & Hoyer, D. An overview of FDA-approved new molecular entities: 1827-2013. Drug Discov. Today 19, 1033-1039 (2014).
    • (2014) Drug Discov. Today , vol.19 , pp. 1033-1039
    • Kinch, M.S.1    Haynesworth, A.2    Kinch, S.L.3    Hoyer, D.4
  • 43
    • 85008193557 scopus 로고    scopus 로고
    • Table of pharmacogenomic biomarkers in drug labeling
    • US Food and Drug Administration. Table of Pharmacogenomic Biomarkers in Drug Labeling. US Food and Drug Administration http://www.fda.gov/drugs/scienceresearch/researchareas/pharmacogenetics/ucm083378.htm (2015).
    • (2015) US Food and Drug Administration
    • US Food and Drug Administration1
  • 45
    • 84920866837 scopus 로고    scopus 로고
    • Preemptive clinical pharmacogenetics implementation: Current programs in five US medical centers
    • Dunnenberger, H. M. et al. Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers. Annu. Rev. Pharmacol. Toxicol. 55, 89-106 (2015).
    • (2015) Annu. Rev. Pharmacol. Toxicol. , vol.55 , pp. 89-106
    • Dunnenberger, H.M.1
  • 47
    • 84875485693 scopus 로고    scopus 로고
    • Cancer pharmacogenomics: Early promise, but concerted effort needed
    • McLeod, H. L. Cancer pharmacogenomics: early promise, but concerted effort needed. Science 339, 1563-1566 (2013).
    • (2013) Science , vol.339 , pp. 1563-1566
    • McLeod, H.L.1
  • 48
    • 0021201236 scopus 로고
    • Cellular DNA content as a predictor of response to chemotherapy in infants with unresectable neuroblastoma
    • Look, A. T., Hayes, F. A., Nitschke, R., McWilliams, N. B. & Green, A. A. Cellular DNA content as a predictor of response to chemotherapy in infants with unresectable neuroblastoma. N. Engl. J. Med. 311, 231-235 (1984).
    • (1984) N. Engl. J. Med. , vol.311 , pp. 231-235
    • Look, A.T.1    Hayes, F.A.2    Nitschke, R.3    McWilliams, N.B.4    Green, A.A.5
  • 49
    • 0025188811 scopus 로고
    • Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia
    • Pui, C. H., Crist, W. M. & Look, A. T. Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Blood 76, 1449-1463 (1990).
    • (1990) Blood , vol.76 , pp. 1449-1463
    • Pui, C.H.1    Crist, W.M.2    Look, A.T.3
  • 50
    • 84896525622 scopus 로고    scopus 로고
    • Similarities and differences in the oncology drug approval process between FDA and European Union with emphasis on in vitro companion diagnostics
    • Senderowicz, A. M. & Pfaff, O. Similarities and differences in the oncology drug approval process between FDA and European Union with emphasis on in vitro companion diagnostics. Clin. Cancer Res. 20, 1445-1452 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 1445-1452
    • Senderowicz, A.M.1    Pfaff, O.2
  • 51
    • 84896512336 scopus 로고    scopus 로고
    • Cancer drug development and the evolving regulatory framework for companion diagnostics in the European Union
    • Pignatti, F. et al. Cancer drug development and the evolving regulatory framework for companion diagnostics in the European Union. Clin. Cancer Res. 20, 1458-1468 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 1458-1468
    • Pignatti, F.1
  • 53
    • 58449117037 scopus 로고    scopus 로고
    • Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia
    • Stocco, G. et al. Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. Clin. Pharmacol. Ther. 85, 164-172 (2009).
    • (2009) Clin. Pharmacol. Ther. , vol.85 , pp. 164-172
    • Stocco, G.1
  • 54
    • 84922393995 scopus 로고    scopus 로고
    • A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia
    • Yang, S. K. et al. A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia. Nature Genet. 46, 1017-1020 (2014).
    • (2014) Nature Genet. , vol.46 , pp. 1017-1020
    • Yang, S.K.1
  • 55
    • 84927137703 scopus 로고    scopus 로고
    • Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia
    • Yang, J. J. et al. Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia. J. Clin. Oncol. 33, 1235-1242 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 1235-1242
    • Yang, J.J.1
  • 56
    • 23044474063 scopus 로고    scopus 로고
    • Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes
    • Cheng, Q. et al. Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. Nature Genet. 37, 878-882 (2005).
    • (2005) Nature Genet. , vol.37 , pp. 878-882
    • Cheng, Q.1
  • 57
    • 84893097016 scopus 로고    scopus 로고
    • Preemptive genotyping for personalized medicine: Design of the right drug, right dose, right time - using genomic data to individualize treatment protocol
    • Bielinski, S. J. et al. Preemptive genotyping for personalized medicine: design of the right drug, right dose, right time - using genomic data to individualize treatment protocol. Mayo Clin. Proc. 89, 25-33 (2014).
    • (2014) Mayo Clin. Proc. , vol.89 , pp. 25-33
    • Bielinski, S.J.1
  • 58
    • 84880716424 scopus 로고    scopus 로고
    • The CLIPMERGE PGx Program: Clinical implementation of personalized medicine through electronic health records and genomics-pharmacogenomics
    • Gottesman, O. et al. The CLIPMERGE PGx Program: clinical implementation of personalized medicine through electronic health records and genomics-pharmacogenomics. Clin. Pharmacol. Ther. 94, 214-217 (2013).
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 214-217
    • Gottesman, O.1
  • 59
    • 84865431148 scopus 로고    scopus 로고
    • Concordance of DMET plus genotyping results with those of orthogonal genotyping methods
    • Fernandez, C. A. et al. Concordance of DMET plus genotyping results with those of orthogonal genotyping methods. Clin. Pharmacol. Ther. 92, 360-365 (2012).
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 360-365
    • Fernandez, C.A.1
  • 60
    • 84866625627 scopus 로고    scopus 로고
    • Implementing personalized medicine: Development of a cost-effective customized pharmacogenetics genotyping array
    • Johnson, J. A. et al. Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array. Clin. Pharmacol. Ther. 92, 437-439 (2012).
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 437-439
    • Johnson, J.A.1
  • 61
    • 84877655072 scopus 로고    scopus 로고
    • Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records
    • Oetjens, M. T. et al. Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records. Pharmacogenomics 14, 735-744 (2013).
    • (2013) Pharmacogenomics , vol.14 , pp. 735-744
    • Oetjens, M.T.1
  • 62
    • 84893475657 scopus 로고    scopus 로고
    • Issues surrounding the health economic evaluation of genomic technologies
    • Buchanan, J., Wordsworth, S. & Schuh, A. Issues surrounding the health economic evaluation of genomic technologies. Pharmacogenomics 14, 1833-1847 (2013).
    • (2013) Pharmacogenomics , vol.14 , pp. 1833-1847
    • Buchanan, J.1    Wordsworth, S.2    Schuh, A.3
  • 63
    • 84877941151 scopus 로고    scopus 로고
    • Phasing out fee-for-service payment
    • Schroeder, S. A. & Frist, W. Phasing out fee-for-service payment. N. Engl. J. Med. 368, 2029-2032 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 2029-2032
    • Schroeder, S.A.1    Frist, W.2
  • 64
    • 84907874984 scopus 로고    scopus 로고
    • Prerequisites to implementing a pharmacogenomics program in a large health-care system
    • Levy, K. D. et al. Prerequisites to implementing a pharmacogenomics program in a large health-care system. Clin. Pharmacol. Ther. 96, 307-309 (2014).
    • (2014) Clin. Pharmacol. Ther. , vol.96 , pp. 307-309
    • Levy, K.D.1
  • 65
    • 84931835165 scopus 로고    scopus 로고
    • Physician attitudes toward adopting genome-guided prescribing through clinical decision support
    • Overby, C. L. et al. Physician attitudes toward adopting genome-guided prescribing through clinical decision support. J. Pers. Med. 4, 35-49 (2014).
    • (2014) J. Pers. Med. , vol.4 , pp. 35-49
    • Overby, C.L.1
  • 66
    • 84906250701 scopus 로고    scopus 로고
    • EMERGEing progress in genomics - The first seven years
    • Crawford, D. C. et al. eMERGEing progress in genomics - the first seven years. Front. Genet. 5, 184 (2014).
    • (2014) Front. Genet. , vol.5 , pp. 184
    • Crawford, D.C.1
  • 67
    • 84902664193 scopus 로고    scopus 로고
    • Warfarin pharmacogenetics: To genotype or not to genotype, that is the question
    • Cavallari, L. H. & Nutescu, E. A. Warfarin pharmacogenetics: to genotype or not to genotype, that is the question. Clin. Pharmacol. Ther. 96, 22-24 (2014).
    • (2014) Clin. Pharmacol. Ther. , vol.96 , pp. 22-24
    • Cavallari, L.H.1    Nutescu, E.A.2
  • 68
    • 84905108461 scopus 로고    scopus 로고
    • Role of phenotypic and genetic testing in managing clopidogrel therapy
    • Chan, N. C. et al. Role of phenotypic and genetic testing in managing clopidogrel therapy. Blood 124, 689-699 (2014).
    • (2014) Blood , vol.124 , pp. 689-699
    • Chan, N.C.1
  • 69
    • 84857237867 scopus 로고    scopus 로고
    • Adoption of pharmacogenomic testing by US physicians: Results of a nationwide survey
    • Stanek, E. J. et al. Adoption of pharmacogenomic testing by US physicians: results of a nationwide survey. Clin. Pharmacol. Ther. 91, 450-458 (2012).
    • (2012) Clin. Pharmacol. Ther. , vol.91 , pp. 450-458
    • Stanek, E.J.1
  • 70
    • 42349098097 scopus 로고    scopus 로고
    • Pharmacogenetics: From bench to byte
    • Swen, J. J. et al. Pharmacogenetics: from bench to byte. Clin. Pharmacol. Ther. 83, 781-787 (2008).
    • (2008) Clin. Pharmacol. Ther. , vol.83 , pp. 781-787
    • Swen, J.J.1
  • 71
    • 79955463893 scopus 로고    scopus 로고
    • Pharmacogenetics: From bench to byte - an update of guidelines
    • Swen, J. J. et al. Pharmacogenetics: from bench to byte - an update of guidelines. Clin. Pharmacol. Ther. 89, 662-673 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 662-673
    • Swen, J.J.1
  • 72
    • 84877097462 scopus 로고    scopus 로고
    • DNA-mutation inventory to refine and enhance cancer treatment (DIRECT): A catalog of clinically relevant cancer mutations to enable genome-directed anticancer therapy
    • Yeh, P. et al. DNA-mutation inventory to refine and enhance cancer treatment (DIRECT): a catalog of clinically relevant cancer mutations to enable genome-directed anticancer therapy. Clin. Cancer Res. 19, 1894-1901 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 1894-1901
    • Yeh, P.1
  • 73
    • 84880467544 scopus 로고    scopus 로고
    • Clinical analysis and interpretation of cancer genome data
    • Van Allen, E. M., Wagle, N. & Levy, M. A. Clinical analysis and interpretation of cancer genome data. J. Clin. Oncol. 31, 1825-1833 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 1825-1833
    • Van Allen, E.M.1    Wagle, N.2    Levy, M.A.3
  • 75
    • 84906486656 scopus 로고    scopus 로고
    • Clinical practice guidelines for translating pharmacogenomic knowledge to bedside. Focus on anticancer drugs
    • Agúndez, J. A., Esguevillas, G., Amo, G. & García-Martín, E. Clinical practice guidelines for translating pharmacogenomic knowledge to bedside. Focus on anticancer drugs. Front. Pharmacol. 5, 188 (2014).
    • (2014) Front. Pharmacol. , vol.5 , pp. 188
    • Agúndez, J.A.1    Esguevillas, G.2    Amo, G.3    García-Martín, E.4
  • 76
    • 84897848726 scopus 로고    scopus 로고
    • Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset
    • Gordon, A. S. et al. Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset. Hum. Mol. Genet. 23, 1957-1963 (2014).
    • (2014) Hum. Mol. Genet. , vol.23 , pp. 1957-1963
    • Gordon, A.S.1
  • 77
    • 84891809093 scopus 로고    scopus 로고
    • ClinVar: Public archive of relationships among sequence variation and human phenotype
    • Landrum, M. J. et al. ClinVar: public archive of relationships among sequence variation and human phenotype. Nucleic Acids Res. 42, D980-D985 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. D980-D985
    • Landrum, M.J.1
  • 78
    • 84930526399 scopus 로고    scopus 로고
    • ClinGen - The Clinical Genome Resource
    • Rehm, H. L. et al. ClinGen - the Clinical Genome Resource. N. Engl. J. Med. 372, 2235-2242 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2235-2242
    • Rehm, H.L.1
  • 79
    • 84866611528 scopus 로고    scopus 로고
    • Pharmacogenomics knowledge for personalized medicine
    • Whirl-Carrillo, M. et al. Pharmacogenomics knowledge for personalized medicine. Clin. Pharmacol. Ther. 92, 414-417 (2012).
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 414-417
    • Whirl-Carrillo, M.1
  • 80
    • 84901269338 scopus 로고    scopus 로고
    • Inferring the semantic relationships of words within an ontology using random indexing: Applications to pharmacogenomics
    • Percha, B., & Altman, R. B. Inferring the semantic relationships of words within an ontology using random indexing: applications to pharmacogenomics. AMIA Annu. Symp. Proc. 2013, 1123-1132 (2013).
    • (2013) AMIA Annu. Symp. Proc. , vol.2013 , pp. 1123-1132
    • Percha, B.1    Altman, R.B.2
  • 81
    • 84885409171 scopus 로고    scopus 로고
    • Making data on essential pharmacogenes available for every patient everywhere: The Medicine Safety Code initiative
    • Samwald, M. & Freimuth, R. R. Making data on essential pharmacogenes available for every patient everywhere: the Medicine Safety Code initiative. Pharmacogenomics 14, 1529-1531 (2013).
    • (2013) Pharmacogenomics , vol.14 , pp. 1529-1531
    • Samwald, M.1    Freimuth, R.R.2
  • 82
    • 84893549013 scopus 로고    scopus 로고
    • Development and use of active clinical decision support for preemptive pharmacogenomics
    • Bell, G. C. et al. Development and use of active clinical decision support for preemptive pharmacogenomics. J. Am. Med. Inform. Assoc. 21, e93-e99 (2014).
    • (2014) J. Am. Med. Inform. Assoc. , vol.21 , pp. e93-e99
    • Bell, G.C.1
  • 83
    • 84875588566 scopus 로고    scopus 로고
    • Harmonization and semantic annotation of data dictionaries from the Pharmacogenomics Research Network: A case study
    • Zhu, Q. et al. Harmonization and semantic annotation of data dictionaries from the Pharmacogenomics Research Network: a case study. J. Biomed. Inform. 46, 286-293 (2013).
    • (2013) J. Biomed. Inform. , vol.46 , pp. 286-293
    • Zhu, Q.1
  • 84
    • 84885151521 scopus 로고    scopus 로고
    • Opportunities for genomic clinical decision support interventions
    • Overby, C. L. et al. Opportunities for genomic clinical decision support interventions. Genet. Med. 15, 817-823 (2013).
    • (2013) Genet. Med. , vol.15 , pp. 817-823
    • Overby, C.L.1
  • 85
    • 84900453857 scopus 로고    scopus 로고
    • An ontology-based, mobile-optimized system for pharmacogenomic decision support at the point-of-care
    • Miñarro-Giménez, J. A., Blagec, K., Boyce, R. D., Adlassnig, K. P. & Samwald, M. An ontology-based, mobile-optimized system for pharmacogenomic decision support at the point-of-care. PLoS ONE 9, e93769 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e93769
    • Miñarro-Giménez, J.A.1    Blagec, K.2    Boyce, R.D.3    Adlassnig, K.P.4    Samwald, M.5
  • 86
    • 84863776772 scopus 로고    scopus 로고
    • Survey of genetic counselors and clinical geneticists' use and attitudes toward pharmacogenetic testing
    • Haga, S. B. et al. Survey of genetic counselors and clinical geneticists' use and attitudes toward pharmacogenetic testing. Clin. Genet. 82, 115-120 (2012).
    • (2012) Clin. Genet. , vol.82 , pp. 115-120
    • Haga, S.B.1
  • 87
    • 84866173399 scopus 로고    scopus 로고
    • Primary care physicians' knowledge of and experience with pharmacogenetic testing
    • Haga, S. B., Burke, W., Ginsburg, G. S., Mills, R. & Agans, R. Primary care physicians' knowledge of and experience with pharmacogenetic testing. Clin. Genet. 82, 388-394 (2012).
    • (2012) Clin. Genet. , vol.82 , pp. 388-394
    • Haga, S.B.1    Burke, W.2    Ginsburg, G.S.3    Mills, R.4    Agans, R.5
  • 88
    • 84902799705 scopus 로고    scopus 로고
    • Finding the missing link for big biomedical data
    • Weber, G. M., Mandl, K. D. & Kohane, I. S. Finding the missing link for big biomedical data. J. Am. Med. Assoc. 311, 2479-2480 (2014).
    • (2014) J. Am. Med. Assoc. , vol.311 , pp. 2479-2480
    • Weber, G.M.1    Mandl, K.D.2    Kohane, I.S.3
  • 89
    • 84878714289 scopus 로고    scopus 로고
    • Geneticists push for global data-sharing
    • Hayden, E. C. Geneticists push for global data-sharing. Nature 498, 16-17 (2013).
    • (2013) Nature , vol.498 , pp. 16-17
    • Hayden, E.C.1
  • 90
    • 84874605951 scopus 로고    scopus 로고
    • Beyond the clinic: 'Direct-to-consumer' genomic profiling services and pharmacogenomics
    • Prainsack, B. & Vayena, E. Beyond the clinic: 'direct-to-consumer' genomic profiling services and pharmacogenomics. Pharmacogenomics 14, 403-412 (2013).
    • (2013) Pharmacogenomics , vol.14 , pp. 403-412
    • Prainsack, B.1    Vayena, E.2
  • 91
    • 83355177995 scopus 로고    scopus 로고
    • DTC genetic testing: Pendulum swings and policy paradoxes
    • Caulfield, T. DTC genetic testing: pendulum swings and policy paradoxes. Clin. Genet. 81, 4-6 (2012).
    • (2012) Clin. Genet. , vol.81 , pp. 4-6
    • Caulfield, T.1
  • 93
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • Shuldiner, A. R. et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. J. Am. Med. Assoc. 302, 849-857 (2009).
    • (2009) J. Am. Med. Assoc. , vol.302 , pp. 849-857
    • Shuldiner, A.R.1
  • 94
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
    • Mega, J. L. et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. J. Am. Med. Assoc. 304, 1821-1830 (2010).
    • (2010) J. Am. Med. Assoc. , vol.304 , pp. 1821-1830
    • Mega, J.L.1
  • 96
    • 84896319802 scopus 로고    scopus 로고
    • Inter-Society Coordinating Committee for Practitioner Education in Genomics. The growing role of professional societies in educating clinicians in genomics
    • Manolio, T. A., Murray, M. F. & Inter-Society Coordinating Committee for Practitioner Education in Genomics. The growing role of professional societies in educating clinicians in genomics. Genet. Med. 16, 571-572 (2014).
    • (2014) Genet. Med. , vol.16 , pp. 571-572
    • Manolio, T.A.1    Murray, M.F.2
  • 97
    • 84903489786 scopus 로고    scopus 로고
    • Framework for development of physician competencies in genomic medicine: Report of the Competencies Working Group of the Inter-Society Coordinating Committee for Physician Education in Genomics
    • Korf, B. R. et al. Framework for development of physician competencies in genomic medicine: report of the Competencies Working Group of the Inter-Society Coordinating Committee for Physician Education in Genomics. Genet. Med. 16, 804-809 (2014).
    • (2014) Genet. Med. , vol.16 , pp. 804-809
    • Korf, B.R.1
  • 98
    • 77649220983 scopus 로고    scopus 로고
    • Genes to society" - The logic and process of the new curriculum for the Johns Hopkins University School of Medicine
    • Wiener, C. M., Thomas, P. A., Goodspeed, E., Valle, D. & Nichols, D. G. "Genes to society" - the logic and process of the new curriculum for the Johns Hopkins University School of Medicine. Acad. Med. 85, 498-506 (2010).
    • (2010) Acad. Med. , vol.85 , pp. 498-506
    • Wiener, C.M.1    Thomas, P.A.2    Goodspeed, E.3    Valle, D.4    Nichols, D.G.5
  • 99
    • 84930433702 scopus 로고    scopus 로고
    • Global implementation of genomic medicine: We are not alone
    • Manolio, T. A. et al. Global implementation of genomic medicine: we are not alone. Sci. Transl. Med. 7, 290ps13 (2015).
    • (2015) Sci. Transl. Med. , vol.7 , pp. 290ps13
    • Manolio, T.A.1
  • 100
    • 78650447994 scopus 로고    scopus 로고
    • Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics
    • Becquemont, L. et al. Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics. Pharmacogenomics 12, 113-124 (2011).
    • (2011) Pharmacogenomics , vol.12 , pp. 113-124
    • Becquemont, L.1
  • 101
    • 84880727398 scopus 로고    scopus 로고
    • The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Overcoming challenges of real-world implementation
    • Shuldiner, A. R. et al. The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation. Clin. Pharmacol. Ther. 94, 207-210 (2013).
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 207-210
    • Shuldiner, A.R.1
  • 102
    • 84862620703 scopus 로고    scopus 로고
    • Operational implementation of prospective genotyping for personalized medicine: The design of the Vanderbilt PREDICT project
    • Pulley, J. M. et al. Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Clin. Pharmacol. Ther. 92, 87-95 (2012).
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 87-95
    • Pulley, J.M.1
  • 103
    • 84896314626 scopus 로고    scopus 로고
    • Adoption of a clinical pharmacogenomics implementation program during outpatient care - initial results of the University of Chicago "1,200 Patients Project"
    • O'Donnell, P. H. et al. Adoption of a clinical pharmacogenomics implementation program during outpatient care - initial results of the University of Chicago "1,200 Patients Project". Am. J. Med. Genet. C. Semin. Med. Genet. 166C, 68-75 (2014).
    • (2014) Am. J. Med. Genet. C. Semin. Med. Genet. , vol.166 C , pp. 68-75
    • O'Donnell, P.H.1
  • 104
    • 84880059657 scopus 로고    scopus 로고
    • The Electronic Medical Records and Genomics (eMERGE) Network: Past, present, and future
    • Gottesman, O. et al. The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet. Med. 15, 761-771 (2013).
    • (2013) Genet. Med. , vol.15 , pp. 761-771
    • Gottesman, O.1
  • 105
    • 84921648422 scopus 로고    scopus 로고
    • Design and anticipated outcomes of the eMERGE-PGx project: A multicenter pilot for preemptive pharmacogenomics in electronic health record systems
    • Rasmussen-Torvik, L. J. et al. Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems. Clin. Pharmacol. Ther. 96, 482-489 (2014).
    • (2014) Clin. Pharmacol. Ther. , vol.96 , pp. 482-489
    • Rasmussen-Torvik, L.J.1
  • 106
  • 107
    • 84904970728 scopus 로고    scopus 로고
    • Building pharmacogenetics into a pharmacovigilance program in Singapore: Using serious skin rash as a pilot study
    • Toh, D. S. et al. Building pharmacogenetics into a pharmacovigilance program in Singapore: using serious skin rash as a pilot study. Pharmacogenomics J. 14, 316-321 (2014).
    • (2014) Pharmacogenomics J. , vol.14 , pp. 316-321
    • Toh, D.S.1
  • 108
    • 84903696254 scopus 로고    scopus 로고
    • Pharmacogenomics of drug-induced hypersensitivity reactions: Challenges, opportunities and clinical implementation
    • Sukasem, C., Puangpetch, A., Medhasi, S. & Tassaneeyakul, W. Pharmacogenomics of drug-induced hypersensitivity reactions: challenges, opportunities and clinical implementation. Asian Pac. J. Allergy Immunol. 32, 111-123 (2014).
    • (2014) Asian Pac. J. Allergy Immunol. , vol.32 , pp. 111-123
    • Sukasem, C.1    Puangpetch, A.2    Medhasi, S.3    Tassaneeyakul, W.4
  • 109
    • 84909974485 scopus 로고    scopus 로고
    • Bridging genomics research between developed and developing countries: The Genomic Medicine Alliance
    • Cooper, D. N. et al. Bridging genomics research between developed and developing countries: the Genomic Medicine Alliance. Pers. Med. 11, 615-623 (2014).
    • (2014) Pers. Med. , vol.11 , pp. 615-623
    • Cooper, D.N.1
  • 110
    • 84919981142 scopus 로고    scopus 로고
    • DruGeVar: An online resource triangulating drugs with genes and genomic biomarkers for clinical pharmacogenomics
    • Dalabira, E. et al. DruGeVar: an online resource triangulating drugs with genes and genomic biomarkers for clinical pharmacogenomics. Public Health Genomics 17, 265-271 (2014).
    • (2014) Public Health Genomics , vol.17 , pp. 265-271
    • Dalabira, E.1
  • 111
    • 84913554859 scopus 로고    scopus 로고
    • Exploring the distribution of genetic markers of pharmacogenomics relevance in Brazilian and Mexican populations
    • Bonifaz-Peña, V. et al. Exploring the distribution of genetic markers of pharmacogenomics relevance in Brazilian and Mexican populations. PLoS ONE 9, e112640 (2014).
    • (2014) PLoS ONE , vol.9
    • Bonifaz-Peña, V.1
  • 112
    • 84904857061 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for rasburicase therapy in the context of G6PD deficiency genotype
    • Relling, M. V. et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for rasburicase therapy in the context of G6PD deficiency genotype. Clin. Pharmacol. Ther. 96, 169-174 (2014).
    • (2014) Clin. Pharmacol. Ther. , vol.96 , pp. 169-174
    • Relling, M.V.1


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