Opportunities for genomic clinical decision support interventions

Genetics in Medicine

Volumn 15, Issue 10, 2013, Pages 817-823

  Overby, Casey Lynnette ^a,b   Kohane, Isaac ^c   Kannry, Joseph L ^d   Williams, Marc S ^e   Starren, Justin ^f   Bottinger, Erwin ^d   Gottesman, Omri ^d   Denny, Joshua C ^g,h   Weng, Chunhua ^a   Tarczy Hornoch, Peter ^i,j,k   Hripcsak, George ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c Harvard Medical School Center for Biomedical Informatics   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e GEISINGER HEALTH SYSTEM   (United States)

^f NORTHWESTERN UNIVERSITY   (United States)

^g VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^h VANDERBILT UNIVERSITY   (United States)

ⁱ UNIVERSITY OF WASHINGTON   (United States)

^j UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^k University of Washington   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A5; MERCAPTOPURINE; ORGANIC ANION TRANSPORTER 2; SIMVASTATIN; TACROLIMUS; WARFARIN;

ARTICLE; CLINICAL DECISION MAKING; DECISION SUPPORT SYSTEM; ELECTRONIC MEDICAL RECORD; EVIDENCE BASED PRACTICE; EXPLORATORY RESEARCH; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HUMAN; INFORMATION RETRIEVAL; KNOWLEDGE MANAGEMENT; LAW; LOGICAL OBSERVATION IDENTIFIERS NAMES AND CODES; MEDICAL INFORMATION; MEDICAL INFORMATION SYSTEM; PATIENT CODING; PATIENT INFORMATION; SINGLE NUCLEOTIDE POLYMORPHISM;

DECISION SUPPORT SYSTEMS, CLINICAL; DECISION SUPPORT TECHNIQUES; DELIVERY OF HEALTH CARE; GENETIC TESTING; GENETICS, MEDICAL; GENOMICS; HUMANS; PROGRAM EVALUATION;

EID: 84885151521     PISSN: 10983600     EISSN: 15300366     Source Type: Journal    
DOI: 10.1038/gim.2013.128     Document Type: Article

References (48)

1. Stanek EJ, Sanders CL, Taber KA, et al. Adoption of pharmacogenomic testing by US physicians: results of a nationwide survey. Clin Pharmacol Ther 2012;91:450-458.
2. Brinner KA, Downing GJ; American Health Information Community Personalized Health Care Workgroup. Advancing patient-centered pediatric care through health information exchange: update from the American Health Information Community Personalized Health Care Workgroup. Pediatrics 2009;123(suppl 2):S122-S124.
3. Kawamoto K, Lobach D F, Willard H F, Ginsburg GS. A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine. BMC Med Inform Decis Mak 2009;9:17.
4. Hoffman MA, Williams MS. Electronic medical records and personalized medicine. Hum Genet 2011;130:33-39.
5. Teich JM, Osheroff JA, Pifer EA, Sittig D F, Jenders RA; CDS Expert Review Panel. Clinical decision support in electronic prescribing: recommendations and an action plan: report of the joint clinical decision support workgroup. J Am Med Inform Assoc 2005;12:365-376.
6. Gottesman O, Kuivaniemi H, Tromp G, et al. The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med 2013;15: 761-771.
7. Tarczy-Hornoch P, Amendola L, Aronson SJ, et al. A survey of informatics approaches to whole-exome and whole-genome clinical reporting in the electronic medical record. Genet Med 2013;15:824-832.
8. Context-aware knowledge retrieval (infobutton) product brief. HL7 International Wiki Site. http://wiki.hl7.org/index.php?title=Infobutton-project. Accessed 16 May 2011.
9. Wright A, Goldberg H, Hongsermeier T, Middleton B. A description and functional taxonomy of rule-based decision support content at a large integrated delivery network. J Am Med Inform Assoc 2007;14:489-496.
10. Wright A, Sittig D F, Ash JS, et al. Development and evaluation of a comprehensive clinical decision support taxonomy: comparison of front-end tools in commercial and internally developed electronic health record systems. J Am Med Inform Assoc 2011;18:232-242.
11. Lobach D F, Sanders GD, Bright TJ, et al. Enabling Health Care Decisionmaking Through Clinical Decision Support and Knowledge Management. Agency for Healthcare Research and Quality: Rockville, MD; 2012.
12. Cresswell KM, Bates DW, Sheikh A. Ten key considerations for the successful implementation and adoption of large-scale health information technology. J Am Med Inform Assoc 2013;20(e1):e9-e13.
13. Sittig DF, Singh H. A new sociotechnical model for studying health information technology in complex adaptive healthcare systems. Qual Saf Health Care 2010;19(suppl 3):i68-i74.
14. United States Department of Health and Human Services, Office of the National Coordinator for Health Information Technology. Personalized Healthcare Detailed Use Case. Rockville, MD. 2008.
15. Glaser J, Henley DE, Downing G, Brinner KM; Personalized Health Care Workgroup of the American Health Information Community. Advancing personalized health care through health information technology: an update from the American Health Information Community's Personalized Health Care Workgroup. J Am Med Inform Assoc 2008;15:391-396.
16. Manolio TA, Chisholm RL, Ozenberger B, et al. Implementing genomic medicine in the clinic: the future is here. Genet Med 2013;15:258-267.
17. Starren J, Williams MS, Bottinger E P. Crossing the Omic Chasm: A Time for Omic Ancillary Systems. JAMA 2013;14:1-2.
18. Hicks JK, Crews KR, Hoffman JM, et al. A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record. Clin Pharmacol Ther 2012;92:563-566.
19. Pulley JM, Denny JC, Peterson J F, et al. Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Clin Pharmacol Ther 2012;92:87-95.
20. Stack CB, Gharani N, Gordon ES, Schmidlen T, Christman MF, Keller MA. Genetic risk estimation in the Coriell Personalized Medicine Collaborative. Genet Med 2011;13:131-139.
21. Aronson SJ, Clark EH, Babb LJ, et al. The GeneInsight Suite: a platform to support laboratory and provider use of DNA-based genetic testing. Hum Mutat 2011;32:532-536.
22. Fenstermacher DA, Wenham RM, Rollison DE, Dalton WS. Implementing personalized medicine in a cancer center. Cancer J 2011;17:528-536.
23. Del Fiol G, Williams MS, Maram N, Rocha RA, Wood GM, Mitchell JA. Integrating genetic information resources with an EHR. AMIA Annu Symp Proc 2006;904.
24. Gottesman O, Scott SA, Ellis SB, et al. The CLIPMERGE PGx Program: Clinical Implementation of Personalized Medicine Through Electronic Health Records and Genomics-Pharmacogenomics. Clin Pharmacol Ther 2013;94:214-217.
25. Nelson DR, Conlon M, Baralt C, Johnson JA, Clare-Salzler MJ, Rawley-Payne M. University of Florida Clinical and Translational Science Institute: transformation and translation in personalized medicine. Clin Transl Sci 2011;4:400-402.
26. Lomotan EA, Hoeksema LJ, Edmonds DE, Ramírez-Garnica G, Shiffman RN, Horwitz LI. Evaluating the use of a computerized clinical decision support system for asthma by pediatric pulmonologists. Int J Med Inform 2012;81:157-165.
27. Dixon BE, Simonaitis L, Goldberg HS, et al. A pilot study of distributed knowledge management and clinical decision support in the cloud. Artif Intell Med, in press e-pub ahead of print, 30 March 2013.
28. Eichner J, Das M, Technology ANRCfHI. Challenges and Barriers to Clinical Decision Support (CDS) Design and Implementation Experienced in the Agency for Healthcare Research and Quality CDS Demonstrations. Agency for Healthcare Research and Quality: Rockville, MD, 2010.
29. Hongsermeier T, Maviglia S, Tsurikova L, et al. A legal framework to enable sharing of Clinical Decision Support knowledge and services across institutional boundaries. AMIA Annu Symp Proc 2011;2011:925-933.
30. Sittig D F, Wright A, Meltzer S, et al. Comparison of clinical knowledge management capabilities of commercially-available and leading internally-developed electronic health records. BMC Med Inform Decis Mak 2011;11:13.
31. Delaney JT, Ramirez AH, Bowton E, et al. Predicting clopidogrel response using DNA samples linked to an electronic health record. Clin Pharmacol Ther 2012;91:257-263.
32. Ramirez AH, Shi Y, Schildcrout JS, et al. Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Pharmacogenomics 2012;13:407-418.
33. Krall MA, Sittig D F. Clinician's assessments of outpatient electronic medical record alert and reminder usability and usefulness requirements. Proc AMIA Symp 2002; 400-404.
34. Kawamoto K, Houlihan CA, Balas EA, Lobach DF. Improving clinical practice using clinical decision support systems: a systematic review of trials to identify features critical to success. BMJ 2005;330:765.
35. Kannry JL, Kushniruk AW, Denny JC, Hoffman M, Levy H, Williams MS. Integrating Genomic Test Results and Decision Support at the Point of Care: Genomics and the EHR. In: Babyatsky M, Giovanni M, Murray M (eds). Clinical Genomics: Practical Applications in Adult Patient Care. McGraw Hill: New York; 2013.
36. Overby CL, Tarczy-Hornoch P, Kalet IJ, et al. Developing a Prototype System for Integrating Pharmacogenomics Findings into Clinical Practice. J Pers Med 2012;2:241-256.
37. Bates DW, Kuperman GJ, Wang S, et al. Ten commandments for effective clinical decision support: making the practice of evidence-based medicine a reality. J Am Med Inform Assoc 2003;10:523-530.
38. Sittig DF, Wright A, Osheroff JA, et al. Grand challenges in clinical decision support. J Biomed Inform 2008;41:387-392.
39. Wright A, Sittig D F. A four-phase model of the evolution of clinical decision support architectures. Int J Med Inform 2008;77:641-649.
40. Kawamoto K, Del Fiol G, Lobach D F, Jenders RA. Standards for scalable clinical decision support: need, current and emerging standards, gaps, and proposal for progress. Open Med Inform J 2010;4:235-244.
41. Pryor TA, Hripcsak G. Sharing MLM's: an experiment between Columbia-Presbyterian and LDS Hospital. Proc Annu Symp Comput Appl Med Care 1993;399-403.
42. Patel VL, Arocha JF, Kushniruk AW. Patients' and physicians' understanding of health and biomedical concepts: relationship to the design of EMR systems. J Biomed Inform 2002;35:8-16.
43. Adida B, Kohane IS. GenePING: secure, scalable management of personal genomic data. BMC Genomics 2006;7:93.
44. GeneTests/GeneReviews. http://www.genetests.org. Accessed 15 March 2013.
45. Archer N, Fevrier-Thomas U, Lokker C, McKibbon KA, Straus SE. Personal health records: a scoping review. J Am Med Inform Assoc 2011;18:515-522.
46. Kaufman DJ, Bollinger JM, Dvoskin RL, Scott JA. Risky business: risk perception and the use of medical services among customers of DTC personal genetic testing. J Genet Couns 2012;21:413-422.
47. Gollust SE, Gordon ES, Zayac C, et al. Motivations and perceptions of early adopters of personalized genomics: perspectives from research participants. Public Health Genomics 2012;15:22-30.
48. Mandl KD, Mandel JC, Murphy SN, et al. The SMART Platform: early experience enabling substitutable applications for electronic health records. J Am Med Inform Assoc 2012;19:597-603.