Development and use of active clinical decision support for preemptive pharmacogenomics

Journal of the American Medical Informatics Association

Volumn 21, Issue E2, 2014, Pages

  Bell, Gillian C ^a   Crews, Kristine R ^a   Wilkinson, Mark R ^a   Haidar, Cyrine E ^a   Hicks, J Kevin ^a   Baker, Donald K ^a   Kornegay, Nancy M ^a   Yang, Wenjian ^a   Cross, Shane J ^a   Howard, Scott C ^a   Freimuth, Robert R ^b   Evans, William E ^a   Broeckel, Ulrich ^c   Relling, Mary V ^a   Hoffman, James M ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b MAYO CLINIC   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; AZATHIOPRINE; CODEINE; CYTOCHROME P450 2D6; FLUOXETINE; MERCAPTOPURINE; PAROXETINE; TIOGUANINE; TRAMADOL;

ARTICLE; DECISION SUPPORT SYSTEM; ELECTRONIC MEDICAL RECORD; PATIENT CARE; PHARMACOGENETICS; PHARMACOGENOMICS; PHENOTYPE; PRESCRIPTION;

CLINICAL DECISION SUPPORT; ELECTRONIC HEALTH RECORD; PERSONALIZED MEDICINE; PHARMACOGENETICS;

DECISION SUPPORT SYSTEMS, CLINICAL; ELECTRONIC HEALTH RECORDS; HUMANS; PHARMACOGENETICS;

EID: 84893549013     PISSN: 10675027     EISSN: 1527974X     Source Type: Journal    
DOI: 10.1136/amiajnl-2013-001993     Document Type: Article

References (41)

1. Osheroff JA, Teich JM, Middleton B, et al. A roadmap for national action on clinical decision support. J Am Med Inform Assoc 2007;14:141-5.
2. Richardson JE, Ash JS, Sittig DF, et al. Multiple perspectives on the meaning of clinical decision support. AMIA Annual Symposium Proceedings; American Medical Informatics Association, 2010.
3. Ash JS, Sittig DF, Guappone KP, et al. Recommended practices for computerized clinical decision support and knowledge management in community settings: a qualitative study. BMC Med Inform Decis Mak 2012;12:6.
4. Troiano D, Jones MA, Smith AH, et al. The need for collaborative engagement in creating clinical decision-support alerts. Am J Health-Syst Pharm 2013;70:150-3.
5. Kaushal R, Shojania KG, Bates DW. Effects of computerized physician order entry and clinical decision support systems on medication safety: a systematic review. Arch Intern Med 2003;163:1409-16.
6. Bright TJ, Wong A, Dhurjati R, et al. Effect of clinical decision-support systems: a systematic review. Ann Intern Med 2012;157:29-43.
7. Jaspers MW, Smeulers M, Vermeulen H, et al. Effects of clinical decision-support systems on practitioner performance and patient outcomes: a synthesis of high-quality systematic review findings. J Am Med Inform Assoc 2011;18:327-34.
8. Wilke RA, Xu H, Denny JC, et al. The emerging role of electronic medical records in pharmacogenomics. Clin Pharmacol Ther 2011;89:379-86.
9. Relling MV, Klein TE. CPIC: Clinical Pharmacogenetics Implementation Consortium of the pharmacogenomics research network. Clin Pharmacol Ther 2011;89:464-7.
10. Evans WE, Crews KR, Pui C-H. A healthcare system perspective on implementing genomic medicine: pediatric acute lymphoblastic leukemia as a paradigm. Clin Pharmacol Ther 2013;94:224-9.
11. Crews KR, Hicks JK, Pui CH, et al. Pharmacogenomics and individualized medicine: translating science into practice. Clin Pharmacol Ther 2012;92:467-75.
12. Welch BM, Kawamoto K. Clinical decision support for genetically guided personalized medicine: a systematic review. J Am Med Inform Assoc 2013;20:388-400.
13. Swen J, Wilting I, De Goede A, et al. Pharmacogenetics: from bench to byte. Clin Pharmacol Ther 2008;83:781-7.
14. O'Donnell PH, Bush A, Spitz J, et al. The 1200 patients project: creating a new medical model system for clinical implementation of pharmacogenomics. Clin Pharmacol Ther 2012;92:446-9.
15. Pulley J, Denny J, Peterson J, et al. Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Clin Pharmacol Ther 2012;92:87-95.
16. Crews KR, Cross SJ, McCormick JN, et al. Development and implementation of a pharmacist-managed clinical pharmacogenetics service. Am J Health Syst Pharm 2011;68:143-50.
17. Fernandez C, Smith C, Yang W, et al. Concordance of DMET Plus genotyping results with those of orthogonal genotyping methods. Clin Pharmacol Ther 2012;92:360-5.
18. Hicks JK, Crews KR, Hoffman JM, et al. A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record. Clin Pharmacol Ther 2012;92:563-6.
19. Hoffman JM, Baker DK, Howard SC, et al. Safe and successful implementation of CPOE for chemotherapy at a children's cancer center. J Natl Compr Canc Netw 2011;9:S-36-50.
20. van der Sijs H, Aarts J, Vulto A, et al. Overriding of drug safety alerts in computerized physician order entry. J Am Med Inform Assoc 2006;13:138-47.
21. HUGO gene nomenclature committee. http://www.genenames.org (accessed 29 Mar 2013).
22. Relling MV, Gardner EE, Sandborn WJ, et al. Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing. Clin Pharmacol Ther 2011;89:387-91.
23. Scott S, Sangkuhl K, Gardner E, et al. Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy. Clin Pharmacol Ther 2011;90:328-32.
24. Crews KR, Gaedigk A, Dunnenberger HM, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clin Pharmacol Ther 2012;91:321-6.
25. Martin MA, Klein TE, Dong BJ, et al. Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing. Clin Pharmacol Ther 2012;91:734-8.
26. Wilke RA, Ramsey LB, Johnson SG, et al. The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Clin Pharmacol Ther 2012;92:112-17.
27. Hershfield MS, Callaghan JT, Tassaneeyakul W, et al. Clinical Pharmacogenetics Implementation Consortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing. Clin Pharmacol Ther 2013;93:153-8.
28. Johnson JA, Gong L, Whirl-Carrillo M, et al. Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing. Clin Pharmacol Ther 2011;90:625-9.
29. Hicks JK, Swen JJ, Thorn CF, et al. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants. Clin Pharmacol Ther 2013;93:402-8.
30. Pui C-H, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006;354:166-78.
31. Pui C-H, Mullighan CG, Evans WE, et al. Pediatric acute lymphoblastic leukemia: where are we going and how do we get there? Blood 2012;120:1165-74.
32. Schmiegelow K, Forestier E, Hellebostad M, et al. Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia. Leukemia 2010;24:345-54.
33. Silverman LB, Stevenson KE, O'Brien JE, et al. Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985-2000). Leukemia 2009;24:320-34.
34. Teng K, Eng C, Hess CA, et al. Building an innovative model for personalized healthcare. Cleve Clin J Med 2012;79 (Suppl 1):S1-9.
35. Isaac T, Weissman JS, Davis RB, et al. Overrides of medication alerts in ambulatory care. Arch Intern Med 2009;169:305-11.
36. Lin CP, Payne TH, Nichol WP, et al. Evaluating clinical decision support systems: monitoring CPOE order check override rates in the Department of Veterans Affairs' Computerized Patient Record System. J Am Med Inform Assoc 2008;15:620-6.
37. Forrey AW, McDonald CJ, DeMoor G, et al. Logical observation identifier names and codes (LOINC) database: a public use set of codes and names for electronic reporting of clinical laboratory test results. Clin Chem 1996;42:81-90.
38. Huff SM, Rocha RA, McDonald CJ, et al. Development of the Logical Observation Identifier Names and Codes (LOINC) vocabulary. J Am Med Inform Assoc 1998;5:276-92.
39. McDonald CJ, Huff SM, Suico JG, et al. LOINC, a universal standard for identifying laboratory observations: a 5-year update. Clin Chem 2003;49:624-33.
40. FDA Drug Safety Communication: Safety review update of codeine use in children; new Boxed Warning and Contraindication on use after tonsillectomy and/or adenoidectomy. http://www.fda.gov/Drugs/DrugSafety/ucm339112.htm (accessed 28 Mar 2013).
41. Johnson JA, Klein TE, Relling MV. Clinical implementation of pharmacogenetics: more than one gene at a time. Clin Pharmacol Ther 2013;93:384-5.