메뉴 건너뛰기




Volumn 31, Issue 2, 2013, Pages 176-180

Tamoxifen use in postmenopausal breast cancer: CYP2D6 matters

Author keywords

[No Author keywords available]

Indexed keywords

ANASTROZOLE; CYTOCHROME P450 2D6; ENDOXIFEN; ESTROGEN RECEPTOR; HORMONE RECEPTOR; PRODRUG; SOMATOMEDIN C; TAMOXIFEN; TOLMETIN;

EID: 84872587241     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2012.44.6625     Document Type: Note
Times cited : (99)

References (36)
  • 1
    • 84859093970 scopus 로고    scopus 로고
    • CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: The Breast International Group 1-98 trial
    • Regan MM, Leyland-Jones B, Bouzyk M, et al: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: The Breast International Group 1-98 trial. J Natl Cancer Inst 104:441-451, 2012
    • (2012) J Natl Cancer Inst , vol.104 , pp. 441-451
    • Regan, M.M.1    Leyland-Jones, B.2    Bouzyk, M.3
  • 2
    • 84859054082 scopus 로고    scopus 로고
    • CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients
    • Rae JM, Drury S, Hayes DF, et al: CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients. J Natl Cancer Inst 104:452-460, 2012
    • (2012) J Natl Cancer Inst , vol.104 , pp. 452-460
    • Rae, J.M.1    Drury, S.2    Hayes, D.F.3
  • 3
    • 84859025949 scopus 로고    scopus 로고
    • CYP2D6 genotype as a marker for benefit of adjuvant tamoxifen in postmenopausal women: Lessons learned
    • Kelly CM, Pritchard KI: CYP2D6 genotype as a marker for benefit of adjuvant tamoxifen in postmenopausal women: Lessons learned. J Natl Cancer Inst 104:427-428, 2012
    • (2012) J Natl Cancer Inst , vol.104 , pp. 427-428
    • Kelly, C.M.1    Pritchard, K.I.2
  • 4
    • 84865486320 scopus 로고    scopus 로고
    • Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: The Breast International Group 1-98 trial
    • Nakamura Y, Ratain MJ, Cox NJ, et al: Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: The Breast International Group 1-98 trial. J Natl Cancer Inst 104:1264, 2012
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1264
    • Nakamura, Y.1    Ratain, M.J.2    Cox, N.J.3
  • 5
    • 84865476035 scopus 로고    scopus 로고
    • Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: The Breast International Group 1-98 trial
    • Stanton V Jr: Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: The Breast International Group 1-98 trial. J Natl Cancer Inst 104:1265-1266, 2012
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1265-1266
    • Stanton Jr., V.1
  • 6
    • 84865515605 scopus 로고    scopus 로고
    • Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: The Breast International Group 1-98 trial and Re: CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients
    • Pharoah PD, Abraham J, Caldas C: Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: The Breast International Group 1-98 trial and Re: CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients. J Natl Cancer Inst 104:1263-1264, 2012
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1263-1264
    • Pharoah, P.D.1    Abraham, J.2    Caldas, C.3
  • 7
    • 80051995856 scopus 로고    scopus 로고
    • Personalized tamoxifen: What is the best way forward?
    • Rae JM: Personalized tamoxifen: What is the best way forward? J Clin Oncol 29:3206-3208, 2011
    • (2011) J Clin Oncol , vol.29 , pp. 3206-3208
    • Rae, J.M.1
  • 8
    • 70449420123 scopus 로고    scopus 로고
    • Use of archived specimens in evaluation of prognostic and predictive biomarkers
    • Simon RM, Paik S, Hayes DF: Use of archived specimens in evaluation of prognostic and predictive biomarkers. J Natl Cancer Inst 101:1446-1452, 2009
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1446-1452
    • Simon, R.M.1    Paik, S.2    Hayes, D.F.3
  • 9
    • 70349929431 scopus 로고    scopus 로고
    • Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen
    • Schroth W, Goetz MP, Hamann U, et al: Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. JAMA 302:1429-1436, 2009
    • (2009) JAMA , vol.302 , pp. 1429-1436
    • Schroth, W.1    Goetz, M.P.2    Hamann, U.3
  • 10
    • 78650890739 scopus 로고    scopus 로고
    • CYP2D6 gene variants: Association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen
    • Abraham JE, Maranian MJ, Driver KE, et al: CYP2D6 gene variants: Association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen. Breast Cancer Res 12:R64, 2010
    • (2010) Breast Cancer Res , vol.12
    • Abraham, J.E.1    Maranian, M.J.2    Driver, K.E.3
  • 11
    • 33644639136 scopus 로고    scopus 로고
    • Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
    • Goetz MP, Rae JM, Suman VJ, et al: Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 23:9312-9318, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 9312-9318
    • Goetz, M.P.1    Rae, J.M.2    Suman, V.J.3
  • 14
    • 0034214364 scopus 로고    scopus 로고
    • A region of deletion on chromosome 22q13 is common to human breast and colorectal cancers
    • Castells A, Gusella JF, Ramesh V, et al: A region of deletion on chromosome 22q13 is common to human breast and colorectal cancers. Cancer Res 60:2836-2839, 2000 (Pubitemid 30395802)
    • (2000) Cancer Research , vol.60 , Issue.11 , pp. 2836-2839
    • Castells, A.1    Gusella, J.F.2    Ramesh, V.3    Rustgi, A.K.4
  • 16
    • 57149093413 scopus 로고    scopus 로고
    • Differential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer
    • Loo LW, Ton C, Wang YW, et al: Differential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer. Genes Chromosomes Cancer 47:1049-1066, 2008
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 1049-1066
    • Loo, L.W.1    Ton, C.2    Wang, Y.W.3
  • 19
    • 77956242845 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms as predictors of outcome in breast cancer patients treated with tamoxifen: Expanded polymorphism coverage improves risk stratification
    • Schroth W, Hamann U, Fasching PA, et al: CYP2D6 polymorphisms as predictors of outcome in breast cancer patients treated with tamoxifen: Expanded polymorphism coverage improves risk stratification. Clin Cancer Res 16:4468-4477, 2010
    • (2010) Clin Cancer Res , vol.16 , pp. 4468-4477
    • Schroth, W.1    Hamann, U.2    Fasching, P.A.3
  • 20
    • 67749114265 scopus 로고    scopus 로고
    • CYP2D6 and tamoxifen: DNA matters in breast cancer
    • Hoskins JM, Carey LA, McLeod HL: CYP2D6 and tamoxifen: DNA matters in breast cancer. Nat Rev Cancer 9:576-586, 2009
    • (2009) Nat Rev Cancer , vol.9 , pp. 576-586
    • Hoskins, J.M.1    Carey, L.A.2    McLeod, H.L.3
  • 21
    • 70349658746 scopus 로고    scopus 로고
    • Pharmacogenomics of tamoxifen therapy
    • Brauch H, Mürdter TE, Eichelbaum M, et al: Pharmacogenomics of tamoxifen therapy. Clin Chem 55:1770-1782, 2009
    • (2009) Clin Chem , vol.55 , pp. 1770-1782
    • Brauch, H.1    Mürdter, T.E.2    Eichelbaum, M.3
  • 23
    • 68749113944 scopus 로고    scopus 로고
    • Targeting of tamoxifen to enhance antitumour action for the treatment and prevention of breast cancer: The 'personalised' approach?
    • Brauch H, Jordan VC: Targeting of tamoxifen to enhance antitumour action for the treatment and prevention of breast cancer: The 'personalised' approach? Eur J Cancer 45:2274-2283, 2009
    • (2009) Eur J Cancer , vol.45 , pp. 2274-2283
    • Brauch, H.1    Jordan, V.C.2
  • 24
    • 0242457704 scopus 로고    scopus 로고
    • Hormonal effects of aromatase inhibitors: Focus on premenopausal effects and interaction with tamoxifen
    • DOI 10.1016/S0960-0760(03)00365-0
    • Dowsett M, Haynes BP: Hormonal effects of aromatase inhibitors: Focus on premenopausal effects and interaction with tamoxifen. J Steroid Biochem Mol Biol 86:255-263, 2003 (Pubitemid 37412564)
    • (2003) Journal of Steroid Biochemistry and Molecular Biology , vol.86 , Issue.3-5 , pp. 255-263
    • Dowsett, M.1    Haynes, B.P.2
  • 25
    • 67651177578 scopus 로고    scopus 로고
    • Genotype-guided tamoxifen therapy: Time to pause for reflection?
    • Lash TL, Lien EA, Sørensen HT, et al: Genotype-guided tamoxifen therapy: Time to pause for reflection? Lancet Oncol 10:825-833, 2009
    • (2009) Lancet Oncol , vol.10 , pp. 825-833
    • Lash, T.L.1    Lien, E.A.2    Sørensen, H.T.3
  • 26
    • 62449153701 scopus 로고    scopus 로고
    • The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells
    • Wu X, Hawse JR, Subramaniam M, et al: The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res 69:1722-1727, 2009
    • (2009) Cancer Res , vol.69 , pp. 1722-1727
    • Wu, X.1    Hawse, J.R.2    Subramaniam, M.3
  • 28
    • 2942547864 scopus 로고    scopus 로고
    • Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine
    • Ratliff B, Dietze EC, Bean GR, et al: Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst 96:883, 2004
    • (2004) J Natl Cancer Inst , vol.96 , pp. 883
    • Ratliff, B.1    Dietze, E.C.2    Bean, G.R.3
  • 31
    • 80052020634 scopus 로고    scopus 로고
    • Genotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: A multicenter study
    • Irvin WJ Jr, Walko CM, Weck KE, et al: Genotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: A multicenter study. J Clin Oncol 29:3232-3239, 2011
    • (2011) J Clin Oncol , vol.29 , pp. 3232-3239
    • Irvin Jr., W.J.1    Walko, C.M.2    Weck, K.E.3
  • 32
    • 79955480679 scopus 로고    scopus 로고
    • Activity levels of tamoxifen metabolites at the estrogen receptor and the impact of genetic polymorphisms of phase i and II enzymes on their concentration levels in plasma
    • Mürdter TE, Schroth W, Bacchus-Gerybadze L, et al: Activity levels of tamoxifen metabolites at the estrogen receptor and the impact of genetic polymorphisms of phase I and II enzymes on their concentration levels in plasma. Clin Pharmacol Ther 89:708-717, 2011
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 708-717
    • Mürdter, T.E.1    Schroth, W.2    Bacchus-Gerybadze, L.3
  • 33
    • 80052971654 scopus 로고    scopus 로고
    • Increasing tamoxifen dose in breast cancer patients based on CYP2D6 genotypes and endoxifen levels: Effect on active metabolite isomers and the antiestrogenic activity score
    • Barginear MF, Jaremko M, Peter I, et al: Increasing tamoxifen dose in breast cancer patients based on CYP2D6 genotypes and endoxifen levels: Effect on active metabolite isomers and the antiestrogenic activity score. Clin Pharmacol Ther 90:605-611, 2011
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 605-611
    • Barginear, M.F.1    Jaremko, M.2    Peter, I.3
  • 35
    • 0022549944 scopus 로고
    • Trans-4-Hydroxytamoxifen concentration and metabolism after local percutaneous administration to human breast
    • Mauvais-Javis P, Baudot N, Castaigne D, et al: Trans-4-Hydroxytamoxifen concentration and metabolism after local percutaneous administration to human breast. Cancer Res 46:1521-1525, 1986 (Pubitemid 16048306)
    • (1986) Cancer Research , vol.46 , Issue.3 , pp. 1521-1525
    • Mauvais-Jarvis, P.1    Baudot, N.2    Castaigne, D.3
  • 36
    • 79959628604 scopus 로고    scopus 로고
    • Preemptive pharmacogenetic testing: Insufficient data equal unsatisfactory guidance
    • McLeod HL, Isaacs KL: Preemptive pharmacogenetic testing: Insufficient data equal unsatisfactory guidance. Ann Intern Med 154:842-844, 2011
    • (2011) Ann Intern Med , vol.154 , pp. 842-844
    • McLeod, H.L.1    Isaacs, K.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.