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Volumn 55, Issue , 2015, Pages 89-106

Preemptive clinical pharmacogenetics implementation: Current programs in five us medical centers

Author keywords

Clinical decision support; Individualized medicine; Personalized medicine; Pharmacogenomics; Precision medicine; Prediction in pharmacology

Indexed keywords

CLINICAL DECISION MAKING; DECISION SUPPORT SYSTEM; EDUCATION; ELECTRONIC MEDICAL RECORD; GENETIC VARIABILITY; GENOTYPE; HOSPITAL; HUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; REVIEW; UNITED STATES; UNIVERSITY HOSPITAL; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; GENETIC SCREENING; GENETICS; HOSPITAL PHARMACY; MEDICAL EDUCATION; NONBIOLOGICAL MODEL; ORGANIZATION AND MANAGEMENT; PATIENT SAFETY; PATIENT SELECTION; PERSONALIZED MEDICINE; PHENOTYPE; PREDICTIVE VALUE; PROGRAM DEVELOPMENT; PROGRAM EVALUATION; RISK ASSESSMENT; RISK FACTOR;

EID: 84920866837     PISSN: 03621642     EISSN: 15454304     Source Type: Book Series    
DOI: 10.1146/annurev-pharmtox-010814-124835     Document Type: Review
Times cited : (373)

References (74)
  • 1
    • 4344574336 scopus 로고    scopus 로고
    • Pharmacogenetics - Five decades of therapeutic lessons from genetic diversity
    • Meyer UA. 2004. Pharmacogenetics - five decades of therapeutic lessons from genetic diversity. Nat. Rev. Genet. 5:669-76
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 669-676
    • Meyer, U.A.1
  • 2
    • 78649631900 scopus 로고    scopus 로고
    • A formal risk-benefit framework for genomic tests: Facilitating the appropriate translation of genomics into clinical practice
    • Veenstra DL, Roth JA, Garrison LP Jr, Ramsey SD, Burke W. 2010. A formal risk-benefit framework for genomic tests: facilitating the appropriate translation of genomics into clinical practice. Genet. Med. 12:686-93
    • (2010) Genet. Med. , vol.12 , pp. 686-693
    • Veenstra, D.L.1    Roth, J.A.2    Garrison, L.P.3    Ramsey, S.D.4    Burke, W.5
  • 3
    • 79951472909 scopus 로고    scopus 로고
    • Charting a course for genomic medicine from base pairs to bedside
    • Green ED, Guyer MS. 2011. Charting a course for genomic medicine from base pairs to bedside. Nature 470:204-13
    • (2011) Nature , vol.470 , pp. 204-213
    • Green, E.D.1    Guyer, M.S.2
  • 4
    • 80053533776 scopus 로고    scopus 로고
    • Genomics reaches the clinic: From basic discoveries to clinical impact
    • Manolio TA, Green ED. 2011. Genomics reaches the clinic: from basic discoveries to clinical impact. Cell 147:14-16
    • (2011) Cell , vol.147 , pp. 14-16
    • Manolio, T.A.1    Green, E.D.2
  • 5
    • 80155192457 scopus 로고    scopus 로고
    • A hub for bench-to-bedside pharmacogenomic-based research
    • Voora D, Ginsburg GS. 2011. A hub for bench-to-bedside pharmacogenomic-based research. Pharmacogenomics 12:1095-98
    • (2011) Pharmacogenomics , vol.12 , pp. 1095-1098
    • Voora, D.1    Ginsburg, G.S.2
  • 7
    • 84893716593 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for IFNL3 (IL28B) genotype and PEG interferon-α-based regimens
    • Muir AJ, Gong L, Johnson SG, Lee MT, Williams MS, et al. 2013. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for IFNL3 (IL28B) genotype and PEG interferon-α-based regimens. Clin. Pharmacol. Ther. 95:141-46
    • (2013) Clin. Pharmacol. Ther. , vol.95 , pp. 141-146
    • Muir, A.J.1    Gong, L.2    Johnson, S.G.3    Lee, M.T.4    Williams, M.S.5
  • 8
    • 84888012165 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing
    • Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, et al. 2013. Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin. Pharmacol. Ther. 94:640-45
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 640-645
    • Caudle, K.E.1    Thorn, C.F.2    Klein, T.E.3    Swen, J.J.4    McLeod, H.L.5
  • 9
    • 84875438476 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics ImplementationConsortium guidelines for thiopurinemethyltransferase genotype and thiopurine dosing: 2013 update
    • Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, et al. 2013. Clinical Pharmacogenetics ImplementationConsortium guidelines for thiopurinemethyltransferase genotype and thiopurine dosing: 2013 update. Clin. Pharmacol. Ther. 93:324-25
    • (2013) Clin. Pharmacol. Ther. , vol.93 , pp. 324-325
    • Relling, M.V.1    Gardner, E.E.2    Sandborn, W.J.3    Schmiegelow, K.4    Pui, C.H.5
  • 10
    • 84883170442 scopus 로고    scopus 로고
    • Clinical pharmacogenetics implementation consortium guidelines for CYP2C19 genotype and clopidogrel therapy: 2013 update
    • Scott SA, Sangkuhl K, Stein CM, Hulot JS, Mega JL, et al. 2013. Clinical pharmacogenetics implementation consortium guidelines for CYP2C19 genotype and clopidogrel therapy: 2013 update. Clin. Pharmacol. Ther. 94:317-23
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 317-323
    • Scott, S.A.1    Sangkuhl, K.2    Stein, C.M.3    Hulot, J.S.4    Mega, J.L.5
  • 11
    • 84883193885 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing
    • Leckband SG, Kelsoe JR, Dunnenberger HM, George AL Jr, Tran E, et al. 2013. Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing. Clin. Pharmacol. Ther. 94:324-28
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 324-328
    • Leckband, S.G.1    Kelsoe, J.R.2    Dunnenberger, H.M.3    George, A.L.4    Tran, E.5
  • 12
    • 84876665512 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants
    • Hicks JK, Swen JJ, Thorn CF, Sangkuhl K, Kharasch ED, et al. 2013. Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants. Clin. Pharmacol. Ther. 93:402-8
    • (2013) Clin. Pharmacol. Ther. , vol.93 , pp. 402-408
    • Hicks, J.K.1    Swen, J.J.2    Thorn, C.F.3    Sangkuhl, K.4    Kharasch, E.D.5
  • 13
    • 84872678727 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics ImplementationConsortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing
    • Hershfield MS, Callaghan JT, Tassaneeyakul W, Mushiroda T, Thorn CF, et al. 2013. Clinical Pharmacogenetics ImplementationConsortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing. Clin. Pharmacol. Ther. 93:153-58
    • (2013) Clin. Pharmacol. Ther. , vol.93 , pp. 153-158
    • Hershfield, M.S.1    Callaghan, J.T.2    Tassaneeyakul, W.3    Mushiroda, T.4    Thorn, C.F.5
  • 14
    • 84862600938 scopus 로고    scopus 로고
    • The Clinical Pharmacogenomics Implementation Consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy
    • Wilke RA, Ramsey LB, Johnson SG, Maxwell WD, McLeod HL, et al. 2012. The Clinical Pharmacogenomics Implementation Consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Clin. Pharmacol. Ther. 92:112-17
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 112-117
    • Wilke, R.A.1    Ramsey, L.B.2    Johnson, S.G.3    Maxwell, W.D.4    McLeod, H.L.5
  • 16
    • 84855968708 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of Cytochrome P450 2D6 (CYP2D6) genotype
    • Crews KR, Gaedigk A, Dunnenberger HM, Klein TE, Shen DD, et al. 2012. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of Cytochrome P450 2D6 (CYP2D6) genotype. Clin. Pharmacol. Ther. 91:321-26
    • (2012) Clin. Pharmacol. Ther. , vol.91 , pp. 321-326
    • Crews, K.R.1    Gaedigk, A.2    Dunnenberger, H.M.3    Klein, T.E.4    Shen, D.D.5
  • 17
    • 80052962391 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing
    • Johnson JA, Gong L, Whirl-Carrillo M, Gage BF, Scott SA, et al. 2011. Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing. Clin. Pharmacol. Ther. 90:625-29
    • (2011) Clin. Pharmacol. Ther. , vol.90 , pp. 625-629
    • Johnson, J.A.1    Gong, L.2    Whirl-Carrillo, M.3    Gage, B.F.4    Scott, S.A.5
  • 18
    • 79960613122 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy
    • Scott SA, Sangkuhl K, Gardner EE, Stein CM, Hulot JS, et al. 2011. Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy. Clin. Pharmacol. Ther. 90:328-32
    • (2011) Clin. Pharmacol. Ther. , vol.90 , pp. 328-332
    • Scott, S.A.1    Sangkuhl, K.2    Gardner, E.E.3    Stein, C.M.4    Hulot, J.S.5
  • 19
    • 79951809968 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics ImplementationConsortium guidelines for thiopurinemethyltransferase genotype and thiopurine dosing
    • Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, et al. 2011. Clinical Pharmacogenetics ImplementationConsortium guidelines for thiopurinemethyltransferase genotype and thiopurine dosing. Clin. Pharmacol. Ther. 89:387-91
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 387-391
    • Relling, M.V.1    Gardner, E.E.2    Sandborn, W.J.3    Schmiegelow, K.4    Pui, C.H.5
  • 20
    • 84897022750 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update
    • Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, et al. 2014. Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin. Pharmacol. Ther. 95:376-82
    • (2014) Clin. Pharmacol. Ther. , vol.95 , pp. 376-382
    • Crews, K.R.1    Gaedigk, A.2    Dunnenberger, H.M.3    Leeder, J.S.4    Klein, T.E.5
  • 21
    • 84904857061 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for rasburicase therapy in the context of G6PD deficiency genotype
    • Relling MV, McDonagh EM, Chang T, Caudle KE, McLeod HL, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for rasburicase therapy in the context of G6PD deficiency genotype. Clin. Pharmacol. Ther. 96:169-74
    • Clin. Pharmacol. Ther. , vol.96 , pp. 169-174
    • Relling, M.V.1    McDonagh, E.M.2    Chang, T.3    Caudle, K.E.4    McLeod, H.L.5
  • 22
    • 49149108240 scopus 로고    scopus 로고
    • Economic evaluation of pharmacogenetic tests
    • Wu AC, Fuhlbrigge AL. 2008. Economic evaluation of pharmacogenetic tests. Clin. Pharmacol. Ther. 84:272-74
    • (2008) Clin. Pharmacol. Ther. , vol.84 , pp. 272-274
    • Wu, A.C.1    Fuhlbrigge, A.L.2
  • 24
    • 47949086046 scopus 로고    scopus 로고
    • Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin
    • Gage BF, Eby C, Johnson JA, Deych E, Rieder MJ, et al. 2008. Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin. Clin. Pharmacol. Ther. 84:326-31
    • (2008) Clin. Pharmacol. Ther. , vol.84 , pp. 326-331
    • Gage, B.F.1    Eby, C.2    Johnson, J.A.3    Deych, E.4    Rieder, M.J.5
  • 25
    • 59549094940 scopus 로고    scopus 로고
    • Effect of CYP2C9 and VKORC1 genotypes on early-phase and steady-state warfarin dosing in Korean patients with mechanical heart valve replacement
    • Kim HS, Lee SS, Oh M, Jang YJ, Kim EY, et al. 2009. Effect of CYP2C9 and VKORC1 genotypes on early-phase and steady-state warfarin dosing in Korean patients with mechanical heart valve replacement. Pharmacogenet. Genomics 19:103-12
    • (2009) Pharmacogenet. Genomics , vol.19 , pp. 103-112
    • Kim, H.S.1    Lee, S.S.2    Oh, M.3    Jang, Y.J.4    Kim, E.Y.5
  • 27
    • 84871311661 scopus 로고    scopus 로고
    • Personal genomic measurements: The opportunity for information integration
    • Altman RB. 2013. Personal genomic measurements: the opportunity for information integration. Clin. Pharmacol. Ther. 93:21-23
    • (2013) Clin. Pharmacol. Ther. , vol.93 , pp. 21-23
    • Altman, R.B.1
  • 28
    • 84880727398 scopus 로고    scopus 로고
    • The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Overcoming challenges of real-world implementation
    • Shuldiner AR, Relling MV, Peterson JF, Hicks K, Freimuth RR, et al. 2013. The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation. Clin. Pharmacol. Ther. 2:207-10
    • (2013) Clin. Pharmacol. Ther. , vol.2 , pp. 207-210
    • Shuldiner, A.R.1    Relling, M.V.2    Peterson, J.F.3    Hicks, K.4    Freimuth, R.R.5
  • 30
  • 32
    • 84920757439 scopus 로고    scopus 로고
    • IMS Health HSRN data brief, Collegeville, PA
    • IMS Health. 2013. National prescription audit. HSRN data brief, Collegeville, PA
    • (2013) National Prescription Audit
  • 33
    • 84866595897 scopus 로고    scopus 로고
    • The 1200 Patients Project: Creating a new medical model system for clinical implementation of pharmacogenomics
    • ODonnell PH, Bush A, Spitz J, Danahey K, Saner D, et al. 2012. The 1200 Patients Project: creating a new medical model system for clinical implementation of pharmacogenomics. Clin. Pharmacol. Ther. 92:446-49
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 446-449
    • Odonnell, P.H.1    Bush, A.2    Spitz, J.3    Danahey, K.4    Saner, D.5
  • 34
    • 80053006359 scopus 로고    scopus 로고
    • The impact of pharmacogenomics on the management of cardiac disease
    • Pereira NL, Weinshilboum RM. 2011. The impact of pharmacogenomics on the management of cardiac disease. Clin. Pharmacol. Ther. 90:493-95
    • (2011) Clin. Pharmacol. Ther. , vol.90 , pp. 493-495
    • Pereira, N.L.1    Weinshilboum, R.M.2
  • 36
    • 84880706320 scopus 로고    scopus 로고
    • Challenges in implementing genomic medicine: The Mayo Clinic Center for Individualized Medicine
    • Farrugia G, Weinshilboum RM. 2013. Challenges in implementing genomic medicine: the Mayo Clinic Center for Individualized Medicine. Clin. Pharmacol. Ther. 94:204-6
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 204-206
    • Farrugia, G.1    Weinshilboum, R.M.2
  • 37
    • 84877645710 scopus 로고    scopus 로고
    • Pharmacogenetics in clinical practice: How far have we come and where are we going?
    • Johnson JA. 2013. Pharmacogenetics in clinical practice: How far have we come and where are we going? Pharmacogenomics 14:835-43
    • (2013) Pharmacogenomics , vol.14 , pp. 835-843
    • Johnson, J.A.1
  • 38
    • 84894051877 scopus 로고    scopus 로고
    • Institutional profile University of Florida and Shands Hospital Personalized Medicine Program: Clinical implementation of pharmacogenetics
    • Johnson JA, Elsey AR, Clare-Salzler MJ, Nessl D, Conlon M, Nelson DR. 2013. Institutional profile: University of Florida and Shands Hospital Personalized Medicine Program: clinical implementation of pharmacogenetics. Pharmacogenomics 14:723-26
    • (2013) Pharmacogenomics , vol.14 , pp. 723-726
    • Johnson, J.A.1    Elsey, A.R.2    Clare-Salzler, M.J.3    Nessl, D.4    Conlon, M.5    Nelson, D.R.6
  • 39
    • 84862620703 scopus 로고    scopus 로고
    • Operational implementation of prospective genotyping for personalized medicine: The design of the Vanderbilt PREDICT project
    • Pulley JM, Denny JC, Peterson JF, Bernard GR, Vnencak-Jones CL, et al. 2012. Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Clin. Pharmacol. Ther. 92:87-95
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 87-95
    • Pulley, J.M.1    Denny, J.C.2    Peterson, J.F.3    Bernard, G.R.4    Vnencak-Jones, C.L.5
  • 40
    • 77953543620 scopus 로고    scopus 로고
    • Clinical implementation of pharmacogenomics: Overcoming genetic exceptionalism
    • Relling MV, Altman RB, Goetz MP, Evans WE. 2010. Clinical implementation of pharmacogenomics: overcoming genetic exceptionalism. Lancet Oncol. 11:507-9
    • (2010) Lancet Oncol. , vol.11 , pp. 507-509
    • Relling, M.V.1    Altman, R.B.2    Goetz, M.P.3    Evans, W.E.4
  • 41
    • 82955233708 scopus 로고    scopus 로고
    • Personalizing medicine with clinical pharmacogenetics
    • Scott SA. 2011. Personalizing medicine with clinical pharmacogenetics. Genet. Med. 13:987-95
    • (2011) Genet. Med. , vol.13 , pp. 987-995
    • Scott, S.A.1
  • 42
    • 84880716424 scopus 로고    scopus 로고
    • The CLIPMERGE PGx Program: Clinical implementation of personalized medicine through electronic health records and genomics- pharmacogenomics
    • Gottesman O, Scott SA, Ellis SB, Overby CL, Ludtke A, et al. 2013. The CLIPMERGE PGx Program: clinical implementation of personalized medicine through electronic health records and genomics- pharmacogenomics. Clin. Pharmacol. Ther. 94:214-17
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 214-217
    • Gottesman, O.1    Scott, S.A.2    Ellis, S.B.3    Overby, C.L.4    Ludtke, A.5
  • 43
    • 84893097016 scopus 로고    scopus 로고
    • Preemptive genotyping for personalizedmedicine: Design of the right drug, right dose, right time-using genomic data to individualize treatment protocol
    • Bielinski SJ, Olson JE, Pathak J, Weinshilboum RM, Wang L, et al. 2014. Preemptive genotyping for personalizedmedicine: design of the right drug, right dose, right time-using genomic data to individualize treatment protocol. Mayo Clin. Proc. 89:25-33
    • (2014) Mayo Clin. Proc. , vol.89 , pp. 25-33
    • Bielinski, S.J.1    Olson, J.E.2    Pathak, J.3    Weinshilboum, R.M.4    Wang, L.5
  • 46
    • 33947216465 scopus 로고    scopus 로고
    • Care patterns in Medicare and their implications for pay for performance
    • Pham HH, Schrag D, OMalley AS, Wu B, Bach PB. 2007. Care patterns in Medicare and their implications for pay for performance. N. Engl. J. Med. 356:1130-39
    • (2007) N. Engl. J. Med. , vol.356 , pp. 1130-1139
    • Pham, H.H.1    Schrag, D.2    Omalley, A.S.3    Wu, B.4    Bach, P.B.5
  • 47
    • 84857237867 scopus 로고    scopus 로고
    • Adoption of pharmacogenomic testing by US physicians: Results of a nationwide survey
    • Stanek EJ, Sanders CL, Taber KA, Khalid M, Patel A, et al. 2012. Adoption of pharmacogenomic testing by US physicians: results of a nationwide survey. Clin. Pharmacol. Ther. 91:450-58
    • (2012) Clin. Pharmacol. Ther. , vol.91 , pp. 450-458
    • Stanek, E.J.1    Sanders, C.L.2    Taber, K.A.3    Khalid, M.4    Patel, A.5
  • 48
    • 79951809825 scopus 로고    scopus 로고
    • CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network
    • Relling MV, Klein TE. 2011. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network. Clin. Pharmacol. Ther. 89:464-67
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 464-467
    • Relling, M.V.1    Klein, T.E.2
  • 50
    • 40949124834 scopus 로고    scopus 로고
    • Anticipating clinical integration of pharmacogenetic treatment strategies for addiction: Are primary care physicians ready?
    • Shields AE, Lerman C. 2008. Anticipating clinical integration of pharmacogenetic treatment strategies for addiction: are primary care physicians ready? Clin. Pharmacol. Ther. 83:635-39
    • (2008) Clin. Pharmacol. Ther. , vol.83 , pp. 635-639
    • Shields, A.E.1    Lerman, C.2
  • 51
    • 84881191075 scopus 로고    scopus 로고
    • Clinical and economic challenges facing pharmacogenomics
    • Cohen J, Wilson A, Manzolillo K. 2013. Clinical and economic challenges facing pharmacogenomics. Pharmacogenomics J. 13:378-88
    • (2013) Pharmacogenomics J. , vol.13 , pp. 378-388
    • Cohen, J.1    Wilson, A.2    Manzolillo, K.3
  • 52
    • 84880383420 scopus 로고    scopus 로고
    • PharmGKB: The Pharmacogenetics and Pharmacogenomics Knowledge Base
    • Thorn CF, Klein TE, Altman RB. 2013. PharmGKB: the Pharmacogenetics and Pharmacogenomics Knowledge Base. Methods Mol. Biol. 1015:311-20
    • (2013) Methods Mol. Biol. , vol.1015 , pp. 311-320
    • Thorn, C.F.1    Klein, T.E.2    Altman, R.B.3
  • 53
    • 84900854522 scopus 로고    scopus 로고
    • Incorporation of pharmacogenomics into routine clinical practice: The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process
    • Caudle KE, Klein TE, Hoffman JM, Muller DJ, Whirl-Carrillo M, et al. 2014. Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process. Curr. Drug Metab. 15:209-17
    • (2014) Curr. Drug Metab. , vol.15 , pp. 209-217
    • Caudle, K.E.1    Klein, T.E.2    Hoffman, J.M.3    Muller, D.J.4    Whirl-Carrillo, M.5
  • 54
    • 59849117793 scopus 로고    scopus 로고
    • Recommendations from the EGAPP Working Group: Can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan?
    • Eval. Genomic Appl. Pract. Prev. Work. Group
    • Eval. Genomic Appl. Pract. Prev. Work. Group. 2009. Recommendations from the EGAPP Working Group: Can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? Genet. Med. 11:15-20
    • (2009) Genet. Med. , vol.11 , pp. 15-20
  • 55
    • 84920867131 scopus 로고    scopus 로고
    • Laboratory medicine practice guidelines: Laboratory analysis and application of pharmacogenetics to clinical practice
    • Valdes R Jr, Payne D, Linder MW. 2010. Laboratory medicine practice guidelines: Laboratory analysis and application of pharmacogenetics to clinical practice. Rep., Natl. Acad. Clin. Biochem.
    • (2010) Rep., Natl. Acad. Clin. Biochem
    • Valdes, R.1    Payne, D.2    Linder, M.W.3
  • 56
    • 78751633462 scopus 로고    scopus 로고
    • Recommendations from the EGAPP Working Group: Routine testing for Factor v Leiden (R506Q) and prothrombin (20210G>A) mutations in adults with a history of idiopathic venous thromboembolism and their adult family members
    • Eval. Genomic Appl. Pract. Prev. Work. Group
    • Eval. Genomic Appl. Pract. Prev. Work. Group. 2011. Recommendations from the EGAPP Working Group: routine testing for Factor V Leiden (R506Q) and prothrombin (20210G>A) mutations in adults with a history of idiopathic venous thromboembolism and their adult family members. Genet. Med. 13:67-76
    • (2011) Genet. Med. , vol.13 , pp. 67-76
  • 58
    • 80053484439 scopus 로고    scopus 로고
    • British Association ofDermatologists guidelines for the safe and effective prescribing of azathioprine 2011
    • Meggitt SJ, Anstey AV, Mohd Mustapa MF, Reynolds NJ, Wakelin S. 2011. British Association ofDermatologists guidelines for the safe and effective prescribing of azathioprine 2011. Br. J. Dermatol. 165:711-34
    • (2011) Br. J. Dermatol. , vol.165 , pp. 711-734
    • Meggitt, S.J.1    Anstey, A.V.2    Mohd Mustapa, M.F.3    Reynolds, N.J.4    Wakelin, S.5
  • 59
    • 84875964664 scopus 로고    scopus 로고
    • The NIH genetic testing registry: A new, centralized database of genetic tests to enable access to comprehensive information and improve transparency
    • Rubinstein WS, Maglott DR, Lee JM, Kattman BL, Malheiro AJ, et al. 2013. The NIH genetic testing registry: A new, centralized database of genetic tests to enable access to comprehensive information and improve transparency. Nucleic Acids Res. 41:D925-35
    • (2013) Nucleic Acids Res. , vol.41 , pp. D925-D935
    • Rubinstein, W.S.1    Maglott, D.R.2    Lee, J.M.3    Kattman, B.L.4    Malheiro, A.J.5
  • 60
    • 30444451921 scopus 로고    scopus 로고
    • Thiopurine methyltransferase in acute lymphoblastic leukemia
    • Relling MV, Pui CH, Cheng C, Evans WE. 2006. Thiopurine methyltransferase in acute lymphoblastic leukemia. Blood 107:843-44
    • (2006) Blood , vol.107 , pp. 843-844
    • Relling, M.V.1    Pui, C.H.2    Cheng, C.3    Evans, W.E.4
  • 62
    • 58449117037 scopus 로고    scopus 로고
    • Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia
    • Stocco G, Cheok MH, Crews KR, Dervieux T, French D, et al. 2009. Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. Clin. Pharmacol. Ther. 85:164-72
    • (2009) Clin. Pharmacol. Ther. , vol.85 , pp. 164-172
    • Stocco, G.1    Cheok, M.H.2    Crews, K.R.3    Dervieux, T.4    French, D.5
  • 65
    • 84865431148 scopus 로고    scopus 로고
    • Concordance of DMET Plus genotyping results with those of orthogonal genotyping methods
    • Fernandez CA, Smith C, Yang W, Lorier R, Crews KR, et al. 2012. Concordance of DMET Plus genotyping results with those of orthogonal genotyping methods. Clin. Pharmacol. Ther. 92:360-65
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 360-365
    • Fernandez, C.A.1    Smith, C.2    Yang, W.3    Lorier, R.4    Crews, K.R.5
  • 66
    • 84867848963 scopus 로고    scopus 로고
    • A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record
    • Hicks JK, Crews KR, Hoffman JM, Kornegay NM, Wilkinson MR, et al. 2012. A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record. Clin. Pharmacol. Ther. 92:563-66
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 563-566
    • Hicks, J.K.1    Crews, K.R.2    Hoffman, J.M.3    Kornegay, N.M.4    Wilkinson, M.R.5
  • 69
    • 84877655072 scopus 로고    scopus 로고
    • Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records
    • Oetjens MT, Denny JC, Ritchie MD, Gillani NB, Richardson DM, et al. 2013. Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records. Pharmacogenomics 14:735-44
    • (2013) Pharmacogenomics , vol.14 , pp. 735-744
    • Oetjens, M.T.1    Denny, J.C.2    Ritchie, M.D.3    Gillani, N.B.4    Richardson, D.M.5
  • 71
    • 84901827552 scopus 로고    scopus 로고
    • Integrating pharmacogenetic information and clinical decision support into the electronic health record
    • Goldspiel BR, Flegel WA, Dipatrizio G, Sissung T, Adams SD, et al. 2013. Integrating pharmacogenetic information and clinical decision support into the electronic health record. J. Am. Med. Inform. Assoc. 3:522-28
    • (2013) J. Am. Med. Inform. Assoc. , vol.3 , pp. 522-528
    • Goldspiel, B.R.1    Flegel, W.A.2    Dipatrizio, G.3    Sissung, T.4    Adams, S.D.5
  • 72
    • 84920813896 scopus 로고    scopus 로고
    • The need for clinical decision support integrated with the electronic health record for the clinical application of whole genome sequencing information
    • Welch B, Kawamoto K. 2013. The need for clinical decision support integrated with the electronic health record for the clinical application of whole genome sequencing information. J. Personalized Med. 3:306-25
    • (2013) J. Personalized Med. , vol.3 , pp. 306-325
    • Welch, B.1    Kawamoto, K.2
  • 74
    • 79958285172 scopus 로고    scopus 로고
    • Effects of clinical decision-support systems on practitioner performance and patient outcomes: A synthesis of high-quality systematic review findings
    • Jaspers MWM, Smeulers M, Vermeulen H, Peute LW. 2011. Effects of clinical decision-support systems on practitioner performance and patient outcomes: A synthesis of high-quality systematic review findings. J. Am. Med. Inform. Assoc. 18:327-34
    • (2011) J. Am. Med. Inform. Assoc. , vol.18 , pp. 327-334
    • Jaspers, M.W.M.1    Smeulers, M.2    Vermeulen, H.3    Peute, L.W.4


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