The inhibition of type i bacterial signal peptidase: Biological consequences and therapeutic potential

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 21, 2015, Pages 4761-4766

  Craney, Arryn ^a   Romesberg, Floyd E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Antibiotic; Arylomycin; Protein secretion; SPase; Virulence

Indexed keywords

ANTIINFECTIVE AGENT; ARYLOMYCIN; ENZYME INHIBITOR; SIGNAL PEPTIDASE I; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; SERINE PROTEINASE; TYPE I SIGNAL PEPTIDASE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIABILITY; BACTERIAL VIRULENCE; BIOLOGY; DRUG DEVELOPMENT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG USE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MODIFICATION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROKARYOTE; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SECRETION; SEQUENCE ANALYSIS; ANTAGONISTS AND INHIBITORS; BACTERIUM; CHEMISTRY; CONFORMATION; DRUG EFFECTS; ENZYMOLOGY; METABOLISM;

ANTI-BACTERIAL AGENTS; BACTERIA; ENZYME INHIBITORS; MEMBRANE PROTEINS; MOLECULAR CONFORMATION; SERINE ENDOPEPTIDASES;

EID: 84944280358     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.07.072     Document Type: Article

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