Inhibitors of bacterial signal peptidase: A series of 6-(substituted oxyethyl)penems

Journal of Antibiotics

Volumn 49, Issue 9, 1996, Pages 921-928

  Allsop, Aileen ^a   Brooks, Gerald ^a   Edwards, Peter D ^a   Kaura, Arun C ^a   Southgate, Robert ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; ENZYME INHIBITOR; SIGNAL PEPTIDASE;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 0029923991     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.49.921     Document Type: Article

References (10)

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8. LEANZA, W. I.; F. DININNO, D. A. MUTHARD, R. R. WILKENING, K. J. WILDONGER, R. W. RATCLIFFE & G. CHRISTENSEN: An efficient synthesis of 2-substituted-thio-6-hydroxyethyl-penem-3-carboxylic acids via 2-thioxopenams. Tet. 39: 2505-2513, 1983
9. JONES, T. K.; S. G. MILLS, R. A. REAMER, D. ASKIN, R. DESMOND, R. P. VOLANTE & SHINKAI: Total synthesis of the immunosuppressant (-)-FK-506. J. Am. Chem. Soc. 111: 1157-1159, 1989
10. BROOM, N. J. P. (Beecham Group Ltd.): β-Lactam antibacterial agents and processes for their preparation. GB 2037277B, May 5, 1983