Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: Design, conformation and conversion to α-ketoamide inhibitors

European Journal of Medicinal Chemistry

Volumn 38, Issue 4, 2003, Pages 351-356

  Bruton, Gordon ^a   Huxley, Anthony ^a   O'Hanlon, Peter ^a   Orlek, Barry ^a   Eggleston, Drake ^b   Humphries, John ^a,c   Readshaw, Simon ^a   West, Andrew ^a   Ashman, Stephen ^a   Brown, Murray ^a   Moore, Keith ^a   Pope, Andrew ^b   O'Dwyer, Karen ^b   Wang, Lei ^b,d  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c Peptide Therapeutics Ltd   (United Kingdom)

^d NONE   (United States)

Author keywords

Inhibitor; Lipopetide; S. aureus; Signal peptidase; SpsB; Substrate

Indexed keywords

ALANINE; ALKYL GROUP; ALPHA KETOAMIDE INHIBITOR; BACTERIAL ENZYME; DECANOYLLEUCYLTHREONYLPROLYLTHREONYLALANYLLYSYLALANYLALANYLSERYLLYSYLISOLEU CYLASPARTYLASPARTATE HYDROXIDE; ENZYME INHIBITOR; LIPOPEPTIDE; LYSINE; PEPTIDE DERIVATIVE; PROLINE; PROTEIN SPSB; SIGNAL PEPTIDASE; SOLVENT; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; BACTERIUM IDENTIFICATION; COMPETITIVE INHIBITION; CONFERENCE PAPER; DRUG CONFORMATION; DRUG DESIGN; ENZYME SUBSTRATE; NUCLEAR MAGNETIC RESONANCE; PH; PROTEIN ANALYSIS; STAPHYLOCOCCUS AUREUS;

EID: 12444304518     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(03)00040-0     Document Type: Conference Paper

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