Crystallographic analysis of bacterial signal peptidase in ternary complex with arylomycin A2 and a β-sultam inhibitor

Biochemistry

Volumn 48, Issue 38, 2009, Pages 8976-8984

  Luo, Chuanyun ^a   Roussel, Patrick ^b   Dreier, Jürg ^b   Page, Malcolm G P ^b   Paetzel, Mark ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING MODES; CATALYTIC CENTER; CATALYTIC DOMAINS; CLOSE PROXIMITY; COCRYSTAL STRUCTURE; CRYSTALLOGRAPHIC ANALYSIS; CRYSTALLOGRAPHIC DATA; FURTHER DEVELOPMENT; INHIBITION ASSAYS; INHIBITOR/SUBSTRATE; MEMBRANE-BOUND; NATURAL PRODUCTS; NONCOVALENT; NOVEL ANTIBIOTICS; SIGNAL PEPTIDASE; SUBSITES; TERNARY COMPLEX;

ANTIBIOTICS; BACTERIOLOGY; BINDING ENERGY; BINDING SITES; ESCHERICHIA COLI;

CRYSTAL STRUCTURE;

ALANINE; ARYLOMYCIN A2; ASPARAGINE; BAL 0019193; GLUTAMINE; LYSINE; MORPHOLINO BETA SULTAM DERIVATIVE; NATURAL PRODUCT; SERINE; SIGNAL PEPTIDASE; UNCLASSIFIED DRUG; ESCHERICHIA COLI PROTEIN; MEMBRANE PROTEIN; OLIGOPEPTIDE; PEPTIDE FRAGMENT; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SULFONAMIDE; TYPE I SIGNAL PEPTIDASE;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME MECHANISM; NONHUMAN; PRIORITY JOURNAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; KINETICS; MACROMOLECULE; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI PROTEINS; KINETICS; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STATIC ELECTRICITY; SULFONAMIDES;

EID: 70349784510     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9009538     Document Type: Article

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