Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 41, 2015, Pages E5583-E5589

  Kudalkar, Emily M ^a,c   Scarborough, Emily A ^a   Umbreit, Neil T ^a,d   Zelter, Alex ^a   Gestaut, Daniel R ^a,e   Riffle, Michael ^a   Johnson, Richard S ^a   MacCoss, Michael J ^b   Asbury, Charles L ^b   Davis, Trisha N ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c LABORATORY FOR MOLECULAR MEDICINE   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e STANFORD UNIVERSITY   (United States)

Author keywords

Kinetochore; Microtubules; MIND Mis12 complex; Mitosis; Ndc80 complex

Indexed keywords

MIS12 MIND COMPLEX; NDC80 COMPLEX; PROTEIN; PROTEIN MTW1; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MULTIPROTEIN COMPLEX; NDC-80 PROTEIN, C ELEGANS;

ALPHA HELIX; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CENTROMERE; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; CROSS LINKING; FLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; ANIMAL; CAENORHABDITIS ELEGANS; GENETICS; METABOLISM; MICROTUBULE; MUTATION; PROTEIN TERTIARY STRUCTURE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; KINETOCHORES; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MULTIPROTEIN COMPLEXES; MUTATION; PROTEIN STRUCTURE, TERTIARY;

EID: 84944081102     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1513882112     Document Type: Article

References (45)

1. Cheeseman IM (2014) The kinetochore. Cold Spring Harb Perspect Biol 6(7):a015826.
2. Biggins S (2013) The composition, functions, and regulation of the budding yeast kinetochore. Genetics 194(4):817-846.
3. Joglekar AP, Bouck DC, Molk JN, Bloom KS, Salmon ED (2006) Molecular architecture of a kinetochore-microtubule attachment site. Nat Cell Biol 8(6):581-585.
4. Johnston K, et al. (2010) Vertebrate kinetochore protein architecture: Protein copy number. J Cell Biol 189(6):937-943.
5. Cheeseman IM, Chappie JS, Wilson-Kubalek EM, Desai A (2006) The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell 127(5):983-997.
6. Obuse C, et al. (2004) A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nat Cell Biol 6(11):1135-1141.
7. Screpanti E, et al. (2011) Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. Curr Biol 21(5):391-398.
8. Joglekar AP, Bloom K, Salmon ED (2009) In vivo protein architecture of the eukaryotic kinetochore with nanometer scale accuracy. Curr Biol 19(8):694-699.
9. Aravamudhan P, Felzer-Kim I, Gurunathan K, Joglekar AP (2014) Assembling the protein architecture of the budding yeast kinetochore-microtubule attachment using FRET. Curr Biol 24(13):1437-1446.
10. Tien JF, et al. (2014) Kinetochore biorientation in Saccharomyces cerevisiae requires a tightly folded conformation of the Ndc80 complex. Genetics 198(4):1483-1493.
11. Wang HW, et al. (2008) Architecture and flexibility of the yeast Ndc80 kinetochore complex. J Mol Biol 383(4):894-903.
12. Maure JF, et al. (2011) The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus end. Curr Biol 21(3):207-213.
13. Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-613.
14. Rago F, Gascoigne KE, Cheeseman IM (2015) Distinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T. Curr Biol 25(5):671-677.
15. Nishino T, et al. (2013) CENP-T provides a structural platform for outer kinetochore
16. Bock LJ, et al. (2012) Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore. Nat Cell Biol 14(6):614-624.
17. Hornung P, et al. (2011) Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex. J Mol Biol 405(2):548-559.
18. Maskell DP, Hu XW, Singleton MR (2010) Molecular architecture and assembly of the yeast kinetochore MIND complex. J Cell Biol 190(5):823-834.
19. Erickson HP (2009) Size and shape of protein molecules at the nanometer level determined by sedimentation, gel filtration, and electron microscopy. Biol Proced Online 11:32-51.
20. Petrovic A, et al. (2010) The MIS12 complex is a protein interaction hub for outer kinetochore assembly. J Cell Biol 190(5):835-852.
21. Wei RR, et al. (2006) Structure of a central component of the yeast kinetochore: The Spc24p/Spc25p globular domain. Structure 14(6):1003-1009.
22. Malvezzi F, et al. (2013) A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors. EMBO J 32(3):409-423.
23. Powers AF, et al. (2009) The Ndc80 kinetochore complex forms load-bearing attachments to dynamic microtubule tips via biased diffusion. Cell 136(5):865-875.
24. Tien JF, et al. (2010) Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B. J Cell Biol 189(4):713-723.
25. Akiyoshi B, et al. (2010) Tension directly stabilizes reconstituted kinetochore-microtubule attachments. Nature 468(7323):576-579.
26. Ciferri C, et al. (2008) Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Cell 133(3):427-439.
27. Alushin GM, et al. (2010) The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature 467(7317):805-810.
28. Lampert F, Mieck C, Alushin GM, Nogales E, Westermann S (2013) Molecular requirements for the formation of a kinetochore-microtubule interface by Dam1 and Ndc80 complexes. J Cell Biol 200(1):21-30.
29. Wei RR, Al-Bassam J, Harrison SC (2007) The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment. Nat Struct Mol Biol 14(1):54-59.
30. Biggins S, Murray AW (2001) The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes Dev 15(23):3118-3129.
31. Tanaka TU, et al. (2002) Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell 108(3):317-329.
32. Verhey KJ, Hammond JW (2009) Traffic control: Regulation of kinesin motors. Nat Rev Mol Cell Biol 10(11):765-777.
33. Friedman DS, Vale RD (1999) Single-molecule analysis of kinesin motility reveals regulation by the cargo-binding tail domain. Nat Cell Biol 1(5):293-297.
34. Coy DL, Hancock WO, Wagenbach M, Howard J (1999) Kinesin's tail domain is an inhibitory regulator of the motor domain. Nat Cell Biol 1(5):288-292.
35. Donovan KW, Bretscher A (2015) Head-to-tail regulation is critical for the in vivo function of myosin V. J Cell Biol 209(3):359-365.
36. He X, Rines DR, Espelin CW, Sorger PK (2001) Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell 106(2):195-206.
37. Wei RR, Sorger PK, Harrison SC (2005) Molecular organization of the Ndc80 complex, an essential kinetochore component. Proc Natl Acad Sci USA 102(15):5363-5367.
38. Hoopmann MR, et al. (2015) Kojak: Efficient analysis of chemically cross-linked protein complexes. J Proteome Res 14(5):2190-2198.
39. Gestaut DR, Cooper J, Asbury CL, Davis TN, Wordeman L (2010) Reconstitution and functional analysis of kinetochore subcomplexes. Methods Cell Biol 95:641-656.
40. Franck AD, Powers AF, Gestaut DR, Davis TN, Asbury CL (2010) Direct physical study of kinetochore-microtubule interactions by reconstitution and interrogation with an optical force clamp. Methods 51(2):242-250.
41. Umbreit NT, Davis TN (2012) Mitosis puts sisters in a strained relationship: Force generation at the kinetochore. Exp Cell Res 318(12):1361-1366.
42. Umbreit NT, et al. (2014) Kinetochores require oligomerization of Dam1 complex to maintain microtubule attachments against tension and promote biorientation. Nat Commun 5:4951.
43. Käll L, Canterbury JD, Weston J, Noble WS, MacCoss MJ (2007) Semi-supervised learning for peptide identification from shotgun proteomics datasets. Nat Methods 4(11):923-925.
44. Rice S, et al. (1999) A structural change in the kinesin motor protein that drives motility. Nature 402(6763):778-784.
45. Sarangapani KK, Akiyoshi B, Duggan NM, Biggins S, Asbury CL (2013) Phosphoregulation promotes release of kinetochores from dynamic microtubules via multiple mechanisms. Proc Natl Acad Sci USA 110(18):7282-7287.