Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity

Journal of Medicinal Chemistry

Volumn 58, Issue 19, 2015, Pages 7833-7849

  Beesu, Mallesh ^a   Caruso, Giuseppe ^a   Salyer, Alex C D ^a   Khetani, Karishma K ^a   Sil, Diptesh ^a   Weerasinghe, Mihiri ^a   Tanji, Hiromi ^b   Ohto, Umeharu ^b   Shimizu, Toshiyuki ^b   David, Sunil A ^a,c  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(2 AMINO 3 PENTYLQUINOLIN 5 YL)METHYL]BENZONITRILE; 3 (2 AMINO 3 PENTYLQUINOLIN 5 YL)BENZONITRILE; 3 PENTYLQUINOLINE 2 AMINE; 3 [(2 AMINO 3 PENTYLQUINOLIN 5 YL)METHYL]BENZONITRILE; 3 [(2 AMINO 3 PENTYLQUINOLIN 5 YL)METHY])BENZAMIDE; 4 (2 AMINO 3 PENTYLQUINOLIN 5 YL)BENZONITRILE; 4 (2 AMINO 3 PENTYLQUINOLIN 5 YL)BUTANENITRILE; 4 (4 AMINOBUTYL) 3 PENTYLQUINOLIN 2 AMINE DIHYDROCHLORIDE; 4 (5 AMINOPENTYL) 3 PENTYLQUINOLIN 2 AMINE DIHYDROCHLORIDE; 4 [(2 AMINO 3 PENTYLQUINOLIN 5 YL)METHYL]BENZONITRILE; 4 [3 (AMINOMETHYL)BENZYL] 3 PENTYLQUINOLIN 2 AMINE DIHYDROCHLORIDE; 4 [4 (AMINOMETHYL)BENZYL] 3 PENTYLQUINOLIN 2 AMINE DIHYDROCHLORIDE; 5 (2 AMINO 3 PENTYLQUINOLIN 5 YL)PENTANENITRILE; 5 (3 (PENT 1 YN 1 YL)QUINOLIN 4 YL)PENTANENITRILE; 5 (3 AMINOPROPYL) 3 PENTYLQUINOLIN 2 AMINE; 5 (4 (AMINOMETHYL)PHENYL) 3 PENTYLQUINOLIN 2 AMINE; 5 (4 AMINOBUTYL) 3 PENTYLQUINOLIN 2 AMINE; 5 (5 AMINOPENTYL) 3 PENTYLQUINOLIN 2 AMINE; 5 BENZYL 3 PENTYLQUINOLIN 2 AMINE; 5 [2 (AMINOMETHYL)BENZYL] 3 PENTYLQUINOLIN 2 AMINE; 5 [3 (AMINOMETHYL)BENZYL] 3 PENTYLQUINOLIN 2 AMINE; 5 [3 (AMINOMETHYL)PHENYL] 3 PENTYLQUINOLIN 2 AMINE; 5 [4 (AMINOMETHYL)BENZYL] 3 PENTYLQUINOLIN 2 AMINE; 6 BROMO 3 PENTYLQUINOLIN 2 AMINE; 7 BROMO 3 PENTYLQUINOLIN 2 AMINE; 8 BROMO 3 PENTYLQUINOLIN 2 AMINE; C2 BUTYLFURO[2,3 C ]QUINOLINE; IMMUNOLOGICAL ADJUVANT; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG; QUINOLINE; QUINOLINE DERIVATIVE; TLR8 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 8;

ADAPTIVE IMMUNITY; ADULT; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; COMPARATIVE STUDY; CRYSTAL STRUCTURE; CYTOKINE INDUCED KILLER CELL; CYTOKINE PRODUCTION; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; FEMALE; HELPER CELL; HUMAN; HYDROGENATION; IMMUNIZATION; IMMUNOSTIMULATION; INNATE IMMUNITY; NONHUMAN; PROTEIN EXPRESSION; RABBIT MODEL; UPREGULATION; AGONISTS; ANIMAL; CHEMISTRY; DRUG EFFECTS; GENETICS; PRECLINICAL STUDY; PROCEDURES; PROTEIN CONFORMATION; RABBIT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ADAPTIVE IMMUNITY; ADJUVANTS, IMMUNOLOGIC; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; PROTEIN CONFORMATION; QUINOLINES; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 8;

EID: 84943783010     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01087     Document Type: Article

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