Potent Adjuvanticity of a Pure TLR7-Agonistic Imidazoquinoline Dendrimer

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Shukla, Nikunj M ^a   Salunke, Deepak B ^a   Balakrishna, Rajalakshmi ^a   Mutz, Cole A ^a   Malladi, Subbalakshmi S ^a   David, Sunil A ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1',1'' [NITRILOTRIS(ETHANE 2,1 DIYL)]TRIS[3 [4 [(4 AMINO 2 BUTYL 1H IMIDAZO[4,5 C]QUINOLIN 1 YL)METHYL]BENZYL]THIOUREA]; ALPHA INTERFERON; ALPHA LACTALBUMIN; CYTOKINE; DENDRIMER; GAMMA INTERFERON; IMIDAZOQUINOLINE DERIVATIVE; IMMUNOGLOBULIN G; N [4 [(4 AMINO 2 BUTYL 1H IMIDAZO[4,5 C]QUINOLIN 1 YL)METHYL]BENZYL] 2 AZIDOACETAMIDE; N1,N1 BIS[2 [DI(PROP 2 YN 1 YL)AMINO]ETHYL] N2,N2 DI(PROP 2 YN YL)ETHANE 1,2 DIAMINE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; EPITOPE MAPPING; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOREACTIVITY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN INDUCTION; PROTEIN MULTIMERIZATION; RABBIT; STRUCTURE ACTIVITY RELATION;

ADJUVANTS, IMMUNOLOGIC; AMINO ACID SEQUENCE; ANIMALS; CATTLE; DENDRIMERS; EPITOPE MAPPING; FEMALE; HUMANS; IMIDAZOLES; LACTALBUMIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; QUINOLINES; RABBITS; TOLL-LIKE RECEPTOR 7;

BOVINAE;

EID: 84865465602     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043612     Document Type: Article

References (32)

1. Kawai T, Akira S, (2007) TLR signaling. Semin Immunol 19: 24-32.
2. Kumagai Y, Takeuchi O, Akira S, (2008) Pathogen recognition by innate receptors. J Infect Chemother 14: 86-92.
3. Akira S, (1902) Toll-like receptors and innate immunity. Adv Immunol 78: 1-56.
4. Akira S, Takeda K, Kaisho T, (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nature Immunol 2: 675-680.
5. Cottalorda A, Verschelde C, Marcais A, Tomkowiak M, Musette P, et al. (2006) TLR2 engagement on CD8 T cells lowers the threshold for optimal antigen-induced T cell activation. Eur J Immunol 36: 1684-1693.
6. Kaisho T, Akira S, (2002) Toll-like receptors as adjuvant receptors. Biochim Biophys Acta 1589: 1-13.
7. Kumagai Y, Takeuchi O, Akira S, (2008) Pathogen recognition by innate receptors. J Infect Chemother 14: 86-92.
8. Hood JD, Warshakoon HJ, Kimbrell MR, Shukla NM, Malladi SS, et al. (2010) Immunoprofiling toll-like receptor ligands Comparison of immunostimulatory and proinflammatory profiles in ex vivo human blood models. Hum Vaccin 6: 1-14.
9. Shukla NM, Kimbrell MR, Malladi SS, David SA, (2009) Regioisomerism-dependent TLR7 agonism and antagonism in an imidazoquinoline. Bioorg Med Chem Lett 19: 2211-2214.
10. Shukla NM, Malladi SS, Mutz CA, Balakrishna R, David SA, (2010) Structure-activity relationships in human toll-like receptor 7-active imidazoquinoline analogues. J Med Chem 53: 4450-4465.
11. Shukla NM, Mutz CA, Ukani R, Warshakoon HJ, Moore DS, et al. (2010) Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorg Med Chem Lett 20: 6384-6386.
12. Shukla NM, Mutz CA, Malladi SS, Warshakoon HJ, Balakrishna R, et al. (2012) Toll-Like Receptor (TLR)-7 and-8 Modulatory Activities of Dimeric Imidazoquinolines. J Med Chem 55: 1106-1116.
13. Shukla NM, Lewis TC, Day TP, Mutz CA, Ukani R, et al. (2011) Bioorg Med Chem Lett. 21: 3232-3236.
14. Botos I, Segal DM, Davies DR, (2011) The structural biology of Toll-like receptors. Structure 19: 447-459.
15. Kang JY, Lee JO, (2011) Structural biology of the Toll-like receptor family. Annu Rev Biochem 80: 917-941.
16. Sil D, Shrestha A, Kimbrell MR, Nguyen TB, Adisechan AK, et al. (2007) Bound to shock: protection from lethal endotoxemic shock by a novel, nontoxic, alkylpolyamine lipopolysaccharide sequestrant.Antimicrob Agents Chemother. 51: 2811-2819.
17. Pullen GR, Fitzgerald MG, Hosking CS, (1986) Antibody avidity determination by ELISA using thiocyanate elution. J Immunol Methods 86: 83-87.
18. Macdonald RA, Hosking CS, Jones CL, (1988) The measurement of relative antibody affinity by ELISA using thiocyanate elution. J Immunol Methods 106: 191-194.
19. Nguyen TB, Kumar EV, Sil D, Wood SJ, Miller KA, et al. (2008) Controlling plasma protein binding: structural correlates of interactions of hydrophobic polyamine endotoxin sequestrants with human serum albumin. Mol Pharm 5: 1131-1137.
20. Warshakoon HJ, Hood JD, Kimbrell MR, Malladi S, Wu WY, et al. (2009) Potential adjuvantic properties of innate immune stimuli. Hum Vaccin 5: 381-394.
21. Gorden KB, Gorski KS, Gibson SJ, Kedl RM, Kieper WC, et al. (2005) Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol 174: 1259-1268.
22. Gorski KS, Waller EL, Bjornton-Severson J, Hanten JA, Riter CL, et al. (2006) Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists. Int Immunol 18: 1115-1126.
23. Kandimalla ER, Struthers M, Bett AJ, Wisniewski T, Dubey SA, et al. (2011) Synthesis and immunological activities of novel Toll-like receptor 7 and 8 agonists. Cell Immunol 270: 126-134.
24. Buttke TM, McCubrey JA, Owen TC, (1993) Use of an aqueous soluble tetrazolium/formazan assay to measure viability and proliferation of lymphokine-dependent cell lines. J Immunol Methods 157: 233-240.
25. Nociari MM, Shalev A, Benias P, Russo C, (1998) A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity. J Immunol Methods 213: 157-167.
26. Ponomarenko JV, Bourne PE, (2007) Antibody-protein interactions: benchmark datasets and prediction tools evaluation. BMC Struct Biol 7: 64.
27. Chou PY, Fasman GD, (1978) Prediction of the secondary structure of proteins from their amino acid sequence. Adv Enzymol Relat Areas Mol Biol 47: 45-148.
28. Emini EA, Hughes JV, Perlow DS, Boger J, (1985) Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide. J Virol 55: 836-839.
29. Karplus PA, Schulz GE, (1985) Prediction of chain flexibility in proteins. Naturwissenschaften 72: 212-213.
30. Kolaskar AS, Tongaonkar PC, (1990) A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett 276: 172-174.
31. Parker JM, Guo D, Hodges RS, (1986) New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sites. Biochemistry 25: 5425-5432.
32. Larsen JE, Lund O, Nielsen M, (2006) Improved method for predicting linear B-cell epitopes. Immunome Res 2: 2.