Structure-activity relationships in nucleotide oligomerization domain 1 (Nod1) agonistic γ-glutamyldiaminopimelic acid derivatives

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1490-1510

  Agnihotri, Geetanjali ^a   Ukani, Rehman ^a   Malladi, Subbalakshmi S ^a   Warshakoon, Hemamali J ^a   Balakrishna, Rajalakshmi ^a   Wang, Xinkun ^a   David, Sunil A ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ALLYL 5 TERT BUTYL 2 [(TERT BUTOXYCARBONYL)AMINO]PENTANEDIOATE; 1 BENZYL 5 TERT BUTYL 2 [(TERT BUTOXYCARBONYL)AMINO]PENTANEDIOATE; 2 [(4 AMINO 4 CARBOXYBUTANAMIDO) 6 DODECANAMIDO]HEPTANEDIOIC ACID; 2 [(4 CARBOXY 4 DODECANAMIDOBUTANAMIDO) 6 DODECANAMIDO]HEPTANEDIOIC ACID; 2 AMINO 6 (4 CARBOXY 4 DODECANAMIDOBUTANAMIDO)HEPTANEDIOIC ACID; 2 AMINO 6 [4 CARBOXY 4 (DODECYLAMINO)BUTANAMIDO]HEPTANEDIOIC ACID; 4 [[[(9H FLUOREN 9 YL)METHOXY]CARBONYL]AMINO] 5 (ALLYLOXY) 5 OXOPENTANOIC ACID; 4 [[[(9H FLUOREN 9 YL)METHOXY]CARBONYL]AMINO] 5 (BENZYLOXY) 5 OXOPENTANOIC ACID; 5 ALLYL 10,14 DIBENZYL 1 (9H FLUOREN 9 YL) 18,18 DIMETHYL 3,8,16 TRIOXO 2,17 DIOXA 4,9,15 TRIAZANONADECANE 5,10,14 TRICARBOXYLATE; 5 BENZYL 10,14 DIETHYL 1 (9H FLUOREN 9 YL) 18,18 DIMETHYL 3,8,16 TRIOXO 2,17 DIOXA 4,9,15 TRIAZANONADECANE 5,10,14 TRICARBOXYLATE; CASPASE RECRUITMENT DOMAIN PROTEIN 4; DIAMINOPIMELIC ACID; DIBENZYL 2 [4 AMINO 5 (BENZYLOXY) 5 OXOPENTANAMIDO] 6 [(TERT BUTOXYCARBONYL)AMINO]HEPTANEDIOATE; DIBENZYL 2 AMINO 6 [(TERT BUTOXYCARBONYL)AMINO]HEPTANEDIOATE; DIBENZYL 2 AMINO 6 [5 (BENZYLOXY) 4 DODECANAMIDO 5 OXOPENTANAMIDO]HEPTANEDIOATE; DIBENZYL 2,6 BIS[(TERT BUTOXYCARBONYL)AMINO]HEPTANEDIOATE; DIETHYL 2 AMINO 6 [(TERT BUTOXYCARBONYL)AMINO]HEPTANEDIOATE; DIETHYL 2,6 BIS[(TERT BUTOXYCARBONYL)AMINO]HEPTANEDIOATE; GAMMA GLUTAMYLDIAMINOPIMELIC ACID; INTERLEUKIN 19; INTERLEUKIN 20; INTERLEUKIN 22; INTERLEUKIN 24; TRIBENZYL 1 (9H FLUOREN 9 YL) 18,18 DIMETHYL 3,8,16 TRIOXO 2,17 DIOXA 4,9,15 TRIAZANONADECANE 5,10,14 TRICARBOXYLATE; TRIBENZYL 1 (9H FLUOREN 9 YL) 3,8,16 TRIOXO 2 OXA 4,9,15 TRIAZAHEPTACOSANE 5,10,14 TRICARBOXYLATE; TRIBENZYL 2,2 DIMETHYL 16 OCTYL 4,12 DIOXO 3 OXA 5,11,16 TRIAZATETRACOSANE 6,10,15 TRICARBOXYLATE; TRIBENZYL 2,2 DIMETHYL 4,12 DIOXO 3 OXA 5,11,16 TRIAZAOCTACOSANE 6,10,15 TRICARBOXYLATE; TRIBENZYL 2,2 DIMETHYL 4,12,17 TRIOXO 3 OXA 5,11,16 TRIAZAOCTACOSANE 6,10,15 TRICARBOXYLATE; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CELL POLARITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TH2 CELL; UPREGULATION;

ADJUVANTS, IMMUNOLOGIC; ANTIGENS, CD11B; DIAMINOPIMELIC ACID; GENE EXPRESSION PROFILING; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INTERLEUKINS; LEUKOCYTES, MONONUCLEAR; MEMBRANE GLYCOPROTEINS; NF-KAPPA B; NOD1 SIGNALING ADAPTOR PROTEIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, IMMUNOLOGIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; UP-REGULATION;

EID: 79952268673     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101535e     Document Type: Article

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