Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines

Journal of Medicinal Chemistry

Volumn 55, Issue 3, 2012, Pages 1106-1116

  Shukla, Nikunj M ^a   Mutz, Cole A ^a   Malladi, Subbalakshmi S ^a   Warshakoon, Hemamali J ^a   Balakrishna, Rajalakshmi ^a   David, Sunil A ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,2' (HEXANE 1,6 DIYL)BIS(1 BENZYL 1H IMIDAZO[4,5 C]QUINOLIN 4 AMINE; 2,2' (PROPANE 1,3 DIYL)BIS(1 BENZYL 1H IMIDAZO[4,5 C]QUINOLIN 4 AMINE; CARBON; CHLOROQUINE; CROSS LINKING REAGENT; GARDIQUIMOD; IMIDAZOLE DERIVATIVE; IMIDAZOQUINOLINE DERIVATIVE; PROPYLENE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

AGONIST; ALLOSTERISM; ARTICLE; BLOOD; CHEMICAL MODIFICATION; CONTROLLED STUDY; CROSS LINKING; CYCLIZATION; CYTOKINE PRODUCTION; DIMERIZATION; DRUG ANTAGONISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IMMUNOMODULATION; OXIDATION;

DIMERIZATION; GENES, REPORTER; HUMANS; IMIDAZOLES; IMMUNITY, INNATE; INTERFERON-ALPHA; INTERLEUKIN-1BETA; INTERLEUKIN-8; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84856918906     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2010207     Document Type: Article

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