Regioisomerism-dependent TLR7 agonism and antagonism in an imidazoquinoline

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 8, 2009, Pages 2211-2214

  Shukla, Nikunj M ^a   Kimbrell, Matthew R ^a   Malladi, Subbalakshmi S ^a   David, Sunil A ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Agonist; Antagonist; Innate Immunity; TLR7; Toll like receptors

Indexed keywords

ALKALINE PHOSPHATASE; GARDIQUIMOD; IMIDAZOQUINOLINE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OLIGONUCLEOTIDE PHOSPHOROTHIOATE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; INNATE IMMUNITY; ISOMERISM; NONHUMAN; REPORTER GENE; RHESUS MONKEY; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMIDAZOLES; QUINOLINES; STEREOISOMERISM; TOLL-LIKE RECEPTOR 7;

MACACA MULATTA;

EID: 63449141617     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.100     Document Type: Article

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