Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 12, 2011, Pages 3801-3811

  Shukla, Nikunj M ^a   Malladi, Subbalakshmi S ^a   Day, Victor ^a   David, Sunil A ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Autoimmune diseases; HIV; Imidazoquinoline; NOESY; TLR7; TLR8; Toll like receptor

Indexed keywords

1 (4 METHOXYBENZYL) 2 PHENYL 1H IMIDAZO[4,5 C]QUINOLINE; 2 METHYL 1 (2 PHENYL 3H IMIDAZO[4,5 C]QUINOLINE 3 YL)PROPAN 2 OL; 2 PHENYL 3(PROP 2 YNYL) 3H IMIDAZO[4,5 C]QUINOLINE; 2 PHENYL 3H IMIDAZO[4,5 C]QUINOLINE; 3 (2 PHENYL 3H IMIDAZO[4,5 C]QUINOLIN 3 YL)PROPAN 1 OL; 3 (4 METHOXYBENZYL) 2 PHENYL 3H IMIDAZO[4,5 C]QUINOLINE; 3 [2 [(ETHYLAMINO)METHYL] 3H IMIDAZO[4,5 C]QUINOLINE 3 YL]PROPAN 1 OL; 3 METHYL 2 PHENYL 3H IMIDAZO[4,5 C]QUINOLINE; 3,5 BIS(4METHOXYBENZYL) 2 PHENYL 3H IMIDAZO[4,5 C]QUINOLINE 5 IUM; 3H IMIDAZOQUINOLINE DERIVATIVE; 5 (4 METHOXYBENZYL) 2 PHENYL 3H IMIDAZO[4,5 C]QUINOLINE 5 IUM; IMIDAZOQUINOLINE DERIVATIVE; N (4 METHOXYBENZYL) 2 PHENYL 1H IMIDAZO[4,5 C]QUINOLINE; N (4 METHOXYBENZYL) 3 NITROQUINOLIN 4 AMINE; N 2 [(ETHYLAMINO)METHYL] 3 (2 HYDROXY 2 METHYLPROPYL 3H IMIDAZO[4,5 C]QUINOLINE 4 YL)OXIDE; N [(3 METHYL 3H IMIDAZO[4,5 C]QUINOLINE 2 YL)METHYL] ETHENAMINE; N [2 [(ETHYLAMINO)METHYL] 3 (2 HYDROXY 2 METHYLPROPYL) 3H IMIDAZO[4,5 C]QUINOLINE 4 YL]BENZAMIDE; N [[3 (4 METHOXYBENZYL) 3H IMIDAZO[4,5 C]QUINOLINE 2 YL]METHYL] ETHENAMINE; N [[3 (PROP 2 YNYL) 3H IMIDAZO[4,5 C]QUINOLINE 2 YL]METHYL]ETHENAMINE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50;

ALKYLATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMIDAZOLIDINES; MOLECULAR STRUCTURE; QUINOLINES; SMALL MOLECULE LIBRARIES; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8;

EID: 79958265938     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.04.052     Document Type: Article

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