The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion

Drug Metabolism and Pharmacokinetics

Volumn 30, Issue 5, 2015, Pages 352-357

  Akamine, Yumiko ^a   Miura, Masatomo ^a   Komori, Hisakazu ^b   Tamai, Ikumi ^b   Ieiri, Ichiro ^c   Yasui Furukori, Norio ^d   Uno, Tsukasa ^e  

^a AKITA UNIVERSITY HOSPITAL   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d HIROSAKI UNIVERSITY   (Japan)

^e Department of Pharmacy   (Japan)

Author keywords

Enantiomer; Fexofenadine; Grapefruit juice; OATP2B1; Pharmacokinetics

Indexed keywords

FEXOFENADINE; ORGANIC ANION TRANSPORTER B; ANTIALLERGIC AGENT; ORGANIC ANION TRANSPORTER; SLCO2B1 PROTEIN, HUMAN; TERFENADINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG URINE LEVEL; ELIMINATION HALF-LIFE; ELIMINATION RATE CONSTANT; ENANTIOMER; ENZYME ACTIVITY; FEMALE; GRAPEFRUIT JUICE; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OPEN STUDY; ORAL CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; RANDOMIZED CONTROLLED TRIAL; RENAL CLEARANCE; STEREOCHEMISTRY; URINARY EXCRETION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; AREA UNDER THE CURVE; BEVERAGE; CHEMISTRY; FOOD DRUG INTERACTION; GRAPEFRUIT; METABOLISM; STEREOISOMERISM; YOUNG ADULT;

ADULT; ANTI-ALLERGIC AGENTS; AREA UNDER CURVE; BEVERAGES; CITRUS PARADISI; CROSS-OVER STUDIES; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; MALE; ORGANIC ANION TRANSPORTERS; STEREOISOMERISM; TERFENADINE; YOUNG ADULT;

EID: 84943587503     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.1016/j.dmpk.2015.06.005     Document Type: Article

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