Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects

European Journal of Clinical Pharmacology

Volumn 68, Issue 5, 2012, Pages 697-708

  Rebello, Sam ^a   Zhao, Sally ^a   Hariry, Sam ^a   Dahlke, Marion ^a   Alexander, Natalya ^a   Vapurcuyan, Arpine ^a   Hanna, Imad ^a   Jarugula, Venkateswar ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Aliskiren; Apple juice; Grapefruit juice; Orange juice; Organic anion transporting polypeptide transporter

Indexed keywords

ALISKIREN; ATORVASTATIN; AURANTIIN; FEXOFENADINE; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 1A2; RIFAMYCIN; UNCLASSIFIED DRUG; WATER;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE; CELL TYPE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; DRUG UPTAKE; ELECTROCARDIOGRAPHY; EMBRYO; FOOD DRUG INTERACTION; GRAPEFRUIT JUICE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IC 50; IN VITRO STUDY; INTESTINE; LABORATORY TEST; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECOMMENDED DRUG DOSE; SIDE EFFECT; SINGLE DRUG DOSE; TOOTH PAIN; VITAL SIGN; VOMITING;

ADULT; AMIDES; ANTIHYPERTENSIVE AGENTS; BEVERAGES; BIOLOGICAL TRANSPORT; CITRUS PARADISI; CROSS-OVER STUDIES; FLAVANONES; FOOD-DRUG INTERACTIONS; FRUIT; FUMARATES; HALF-LIFE; HEK293 CELLS; HUMANS; INTESTINAL MUCOSA; MALE; ORGANIC ANION TRANSPORTERS; RECOMBINANT PROTEINS; RENIN; TERFENADINE; YOUNG ADULT;

EID: 84864277039     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-011-1167-4     Document Type: Article

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