Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein

Journal of Pharmaceutical Sciences

Volumn 100, Issue 9, 2011, Pages 3843-3853

  Shirasaka, Yoshiyuki ^a   Suzuki, Kensuke ^a   Nakanishi, Takeo ^a   Tamai, Ikumi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Grapefruit juice; Interaction; Intestinal absorption; Naringin; OATP; P glycoprotein; Pitavastatin; Pravastatin

Indexed keywords

AURANTIIN; GLYCOPROTEIN P; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER 3; PITAVASTATIN; PRAVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG UPTAKE; FOOD DRUG INTERACTION; GRAPEFRUIT JUICE; INHIBITION KINETICS; INTESTINE ABSORPTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PROTEIN EXPRESSION; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 79960116359     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22586     Document Type: Article

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