Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1

Pharmaceutical Research

Volumn 31, Issue 8, 2014, Pages 2035-2043

  Shirasaka, Yoshiyuki ^a   Mori, Takanori ^a   Murata, Yukiko ^a   Nakanishi, Takeo ^a   Tamai, Ikumi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Drug interaction; Grapefruit juice; Intestinal absorption; Multiple binding sites; OATP2B1

Indexed keywords

FEXOFENADINE; ORGANIC ANION TRANSPORTER; PRAVASTATIN; SLCO2B1 PROTEIN, HUMAN; TERFENADINE;

ANALOGS AND DERIVATIVES; ANIMAL; BEVERAGE; BINDING SITE; CELL CULTURE; DOSE RESPONSE; ENZYME SPECIFICITY; FEMALE; FOOD DRUG INTERACTION; GRAPEFRUIT; METABOLISM; OOCYTE; PHYSIOLOGY; XENOPUS LAEVIS;

ANIMALS; BEVERAGES; BINDING SITES; CELLS, CULTURED; CITRUS PARADISI; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOOD-DRUG INTERACTIONS; OOCYTES; ORGANIC ANION TRANSPORTERS; PRAVASTATIN; SUBSTRATE SPECIFICITY; TERFENADINE; XENOPUS LAEVIS;

EID: 84893865593     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1305-7     Document Type: Article

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