Proinflammatory role of the histamine H4 receptor in dextrane sodium sulfate-induced acute colitis

Biochemical Pharmacology

Volumn 98, Issue 1, 2015, Pages 102-109

  Schirmer, Bastian ^a   Rezniczek, Thomas ^a   Seifert, Roland ^a   Neumann, Detlef ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cytokines; Experimental colitis; Histamine; Histamine H4 receptor; Inflammatory bowel diseases

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; HISTAMINE H4 RECEPTOR; 1-((5-CHLORO-1H-INDOL-2-YL)CARBONYL)-4-METHYLPIPERAZINE; CYTOKINE; DEXTRAN SULFATE; G PROTEIN COUPLED RECEPTOR; HISTAMINE RECEPTOR; HRH4 PROTEIN, MOUSE; INDOLE DERIVATIVE; PIPERAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLON; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DEXTRAN SODIUM SULFATE-INDUCED COLITIS; DISEASE COURSE; DISEASE SEVERITY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; CHEMICALLY INDUCED; COLITIS; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ANIMALS; COLITIS; CYTOKINES; DEXTRAN SULFATE; GENE EXPRESSION REGULATION; INDOLES; MICE; MICE, KNOCKOUT; PIPERAZINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE;

EID: 84943453384     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.09.006     Document Type: Article

References (45)

1. R. Seifert, A. Strasser, E.H. Schneider, D. Neumann, S. Dove, and A. Buschauer Molecular and cellular analysis of human histamine receptor subtypes Trends Pharmacol. Sci. 34 2013 33 58
2. 4 receptor J. Immunol. 173 2004 2078 2083
3. 4-receptor: evidence for ligand-specific receptor conformations Biochem. Pharmacol. 84 2012 192 203
4. M. Jutel, M. Akdis, and C.A. Akdis Histamine, histamine receptors and their role in immune pathology Clin. Exp. Allergy 39 2009 1786 1800
5. 2 receptors Nature 413 2001 420 425
6. 4 receptors in allergic inflammation: the search for new antihistamines Nat. Rev. Drug Discov. 7 2008 41 53
7. 4 receptor mediates chemotaxis and calcium mobilization of mast cells J. Pharmacol. Exp. Ther. 305 2003 1212 1221
8. 3 receptors J. Investig. Dermatol. 123 2004 116 123
9. 4 receptor as a new therapeutic target for inflammation Trends Pharmacol. Sci. 26 2005 462 469
10. 4 receptor J. Allergy Clin. Immunol. 120 2007 300 307
11. 4) receptor activation on human slan-dendritic cells down-regulates their pro-inflammatory capacity Immunology 132 2011 49 56
12. K.L. Morse, J. Behan, T.M. Laz, R.E. West Jr., S.A. Greenfeder, J.C. Anthes, and et al. Cloning and characterization of a novel human histamine receptor J. Pharmacol. Exp. Ther. 296 2001 1058 1066
13. 4-receptor: evidence for ligand-specific receptor conformations Biochem. Pharmacol. 84 2012 192 203
14. 4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis Ann. Rheum. Dis. 73 2014 600 608
15. S. Beermann, S. Glage, D. Jonigk, R. Seifert, and D. Neumann Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation PLoS One 7 2012 e30285
16. 4 receptor in atopic dermatitis Curr. Allergy Asthma Rep. 11 2011 21 28
17. 4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus J. Allergy Clin. Immunol. 119 2007 176 183
18. 4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells J. Immunol. 176 2006 7062 7070
19. 4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines Respir. Res. 11 2010 86 10.1186/1465-9921-11-86
20. C.N. Bernstein, J.F. Blanchard, E. Kliewer, and A. Wajda Cancer risk in patients with inflammatory bowel disease: a population-based study Cancer 91 2001 854 862
21. C.N. Bernstein, J.F. Blanchard, P. Rawsthorne, and N. Yu The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study Am. J. Gastroenterol. 96 2001 1116 1122
22. D.C. Baumgart, and W.J. Sandborn Inflammatory bowel disease: clinical aspects and established and evolving therapies Lancet 369 2007 1641 1657
23. Y.L. Jones-Hall, and M.B. Grisham Immunopathological characterization of selected mouse models of inflammatory bowel disease: comparison to human disease Pathophysiology 21 2014 267 288
24. S. Wirtz, C. Neufert, B. Weigmann, and M.F. Neurath Chemically induced mouse models of intestinal inflammation Nat. Protoc. 2 2007 541 546
25. L. Bene, Z. Sapi, A. Bajtai, E. Buzas, A. Szentmihalyi, A. Arato, and et al. Partial protection against dextran sodium sulphate induced colitis in histamine-deficient, histidine decarboxylase knockout mice J. Pediatr. Gastroenterol. Nutr. 39 2004 171 176
26. M. Raithel, M. Matek, H.W. Baenkler, W. Jorde, and E.G. Hahn Mucosal histamine content and histamine secretion in Crohn's disease, ulcerative colitis and allergic enteropathy Int. Arch. Allergy Immunol. 108 1995 127 133
27. D. Neumann, and R. Seifert The therapeutic potential of histamine receptor ligands in inflammatory bowel disease Biochem. Pharmacol. 91 2014 12 17
28. 4 receptor antagonists on experimental colitis in the rat Eur. J. Pharmacol. 522 2005 130 138
29. D. Neumann, E.H. Schneider, and R. Seifert Analysis of histamine receptor knockout mice in models of inflammation J. Pharmacol. Exp. Ther. 348 2014 2 11
30. 4 receptor antagonist with anti-inflammatory properties J. Pharmacol. Exp. Ther. 309 2004 404 413
31. 4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity Mol. Pharmacol. 79 2011 631 638
32. P. Alex, N.C. Zachos, T. Nguyen, L. Gonzales, T.E. Chen, L.S. Conklin, and et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis Inflamm. Bowel Dis. 15 2009 341 352
33. A. Bleich, M. Mahler, C. Most, E.H. Leiter, E. Liebler-Tenorio, C.O. Elson, and et al. Refined histopathologic scoring system improves power to detect colitis QTL in mice Mamm. Genome 15 2004 865 871
34. 2)-receptor reduces alpha-CD3-induced interferon-gamma synthesis in murine CD4+ T cells in an indirect manner J. Interferon Cytokine Res. 32 2012 185 190
35. 1 receptors contribute to postinflammatory visceral hypersensitivity Gut 63 2014 1873 1882
36. E.A. van Hoboken, A.Y. Thijssen, R. Verhaaren, P.P. van der Veek, F.A. Prins, H.W. Verspaget, and et al. Symptoms in patients with ulcerative colitis in remission are associated with visceral hypersensitivity and mast cell activity Scand. J. Gastroenterol. 46 2011 981 987
37. A. Rijnierse, F.P. Nijkamp, and A.D. Kraneveld Mast cells and nerves tickle in the tummy: implications for inflammatory bowel disease and irritable bowel syndrome Pharmacol. Ther. 116 2007 207 235
38. M.A. Kuefner, H.G. Schwelberger, E.G. Hahn, and M. Raithel Decreased histamine catabolism in the colonic mucosa of patients with colonic adenoma Dig. Dis. Sci. 53 2008 436 442
39. A.F. Bento, R.F. Claudino, R.C. Dutra, R. Marcon, and J.B. Calixto Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice J. Immunol. 187 2011 1957 1969
40. K. Singh, R. Chaturvedi, D.P. Barry, L.A. Coburn, M. Asim, N.D. Lewis, and et al. The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis J. Biol. Chem. 286 2011 3839 3850
41. R.C. Dutra, R.F. Claudino, A.F. Bento, R. Marcon, E.C. Schmidt, Z.L. Bouzon, and et al. Preventive and therapeutic euphol treatment attenuates experimental colitis in mice PLoS One 6 2011 e27122
42. O.H. Nielsen New strategies for treatment of inflammatory bowel disease Front. Med. (Lausanne) 1 2014 3
43. C.J. Grossman Interactions between the gonadal steroids and the immune system Science 227 1985 257 261
44. S.L. Klein The effects of hormones on sex differences in infection: from genes to behavior Neurosci. Biobehav. Rev. 24 2000 627 638
45. D. Furman, B.P. Hejblum, N. Simon, V. Jojic, C.L. Dekker, R. Thiebaut, and et al. Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination Proc. Natl. Acad. Sci. U. S. A. 111 2014 869 874